Anal Histopathology

  • Claus Fenger


Anal Canal Dentate Line Perianal Skin Anal Gland Vulvar Intraepithelial Neoplasia 
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  1. 1.
    Fenger C. Anal canal. In: Sternberg SS, editor. Histology for pathologists. 2nd ed. Philadelphia, PA: Lippincott-Raven; 1997. pp. 551–69.Google Scholar
  2. 2.
    Fenger C, Frisch M, Marti MC, and Parc R. Tumours of the anal canal. In: Hamilton SR and Aaltonen LA, editors. World Health Organization classification of tumours. Pathology and genetics of tumours of the digestive system. Lyon, France: IARC Press; 2000. pp. 146–55.Google Scholar
  3. 3.
    Fenger C. The anal transitional zone. Location and extent. Acta Pathol Microbiol Scand. 1979;87:379–386.Google Scholar
  4. 4.
    Thompson-Fawcett MW, Warren BF, and Mortensen NJ. A new look at the anal transitional zone with reference to restorative proctocolectomy and the columnar cuff. Br J Surg. 1998;85:1517–21.PubMedCrossRefGoogle Scholar
  5. 5.
    McColl I. The comparative anatomy and pathology of anal glands. Ann R Coll Surg Engl. 1967;40:36–67.PubMedGoogle Scholar
  6. 6.
    van der Putte SCJ. Mammary-like glands of the vulva and their disorders. Int J Gynecol Pathol. 1994;13:150–60.PubMedCrossRefGoogle Scholar
  7. 7.
    Sultan S, Azria F, Bauer P, Abdelnom M, and Atienza P. Anoperineal tuberculosis. Diagnostic and management considerations in seven cases. Dis Colon Rectum. 2002;45:405–10.CrossRefGoogle Scholar
  8. 8.
    Chang J-W, Wu T-Z, Wang K-S, Huang I-F, Huang B, and Yu I-T. Colon mucosal pathology in infants under three months of age with diarrhea disorders. J Pediatr Gastroenterol Nutr. 2002;35:386–90.Google Scholar
  9. 9.
    Cohen SM, Schmitt SL, Lucas FY, and Wexner SD. The diagnosis of anal ulcers in AIDS patients. Int J Colorectal Dis. 1994;9:169–73.PubMedCrossRefGoogle Scholar
  10. 10.
    Fenger C and Schrøder HD. Neuronal hyperplasia in the anal canal. Histopathology. 1990; 16:481–85.PubMedCrossRefGoogle Scholar
  11. 11.
    Kaftan SM and Haboubi NY. Histopathological changes in haemorrhoid associated mucosa and submucosa. Int J Colorect Dis. 1995;10:15–18.CrossRefGoogle Scholar
  12. 12.
    Fenger C and Nielsen VT. Dysplastic changes in the anal canal epithelium in minor surgical specimens. Acta Path Microbiol Scand Sect A. 1981;89:463–65.Google Scholar
  13. 13.
    Nelson RL, Abcarian H, Davis FG, Persky Y. Prevalence of benign anorectal disease in a randomly selected population. Dis Colon Rect. 1995;38:341–44.CrossRefGoogle Scholar
  14. 14.
    Ravindranauth NS, Borkowski J, and Broaddus R. Metastatic renal cell carcinoma presenting as a hemorrhoid. Arch Pathol Lab Med. 2002;126:856–58.Google Scholar
  15. 15.
    Wienert Y, Albrecht O, and Gablen W. Haufigkeitsanalytische ergebnisse uber marisken [Results of incidence analyses in fibrous polyps]. Der Hautartz. 1978;29:536–40.Google Scholar
  16. 16.
    Gupta PJ and Kalaskar S. Removal of hypertrophied anal papillae and fibrous anal polyps increases patient satisfaction after anal fissure surgery. Tech Coloproctol. 2003;7:155–8.PubMedCrossRefGoogle Scholar
  17. 17.
    Groisman GM and Polak-Charcon S. Fibroepithelial polyps of the anus. A histologic, immunohistochemical, and ultrastructural study, including comparison with the normal anal subepithelial layer. Am J Surg Pathol. 1998;22:70–6.PubMedCrossRefGoogle Scholar
  18. 18.
    Tsang P and Rotterdam H. Biopsy diagnosis of colitis: possibilities and pitfalls. Am J Surg Pathol. 1999;23:423–30.PubMedCrossRefGoogle Scholar
  19. 19.
    Rex DK, Alikhan M, Cummings O, and Ulbright TM. Accuracy of pathological interpretation of colorectal polyps by general pathologists in community practice. Gastrointest Endosc. 1999;50:468–74.PubMedCrossRefGoogle Scholar
  20. 20.
    Godbole P, Botterill I, NewelI SJ, Sagar PM, and Stringer MD. Solitary rectal ulcer in children. J R Coll Surg Edinb. 2000;45:411–14.PubMedGoogle Scholar
  21. 21.
    Kang YS, Kamm MA, Engel AF, and Talbot IC. Pathology of the rectal wall in solitary rectal ulcer syndrome and complete rectal prolapse. Gut. 1996;38:587–90.PubMedGoogle Scholar
  22. 22.
    Tendler DA, Aboudola S, Zacks JF, O’Brien MJ, and Kelly CP. Prolapsing mucosal polyps: an under-recognized form of colonic polyp—a clinicopathological study of 15 cases. Am J Gastroenterol. 2002;97:370–6.PubMedGoogle Scholar
  23. 23.
    Li SC and Hamilton SR. Malignant tumors in the rectum simulating solitary rectal ulcer syndrome in endoscopic biopsy specimens. Am J Surg Pathol. 1998;22:106–12.PubMedCrossRefGoogle Scholar
  24. 24.
    Jaworski RC, Biankin SA, and Baird PJ. Squamous cell carcinoma in situ arising in inflammatory cloacogenic polyps: report of two cases with PCR analysis for H PY DNA. Pathology. 2001;33:312–4.PubMedCrossRefGoogle Scholar
  25. 25.
    Newgreen D and Young HM. Enteric nervous system: development and developmental disturbances—part 1. Pediatr Dev Pathol. 2002;5:224–47.PubMedGoogle Scholar
  26. 26.
    Newgreen D and Young HM. Enteric nervous system: development and developmental disturbances—part 2. Pediatr Dev Pathol. 2002;5:329–49.PubMedCrossRefGoogle Scholar
  27. 27.
    Hofstra RMW, Osinga J, and Buys CHCM. Mutations in Hirschsprung disease: when does a mutation contribute to the phenotype. Eur J Hum Genet. 1997;5:180–5.PubMedGoogle Scholar
  28. 28.
    Fu CG, Muto T, Masaki T, and Nagawa H. Zonal adult Hirschsprung’s disease. Gut. 1996;39:765–7.PubMedGoogle Scholar
  29. 29.
    Moore BG, Singiram C, Eckhoff DE, Gaumnitz EA, and Starling JR. Immunohistochemical evaluations of ultrashort-segment Hirschsprung disease. Dis Colon Rectum. 1996;39:817–22.PubMedCrossRefGoogle Scholar
  30. 30.
    Qualman SJ, Jaffe R, Bove KE, and Monforte-Munoz H. Diagnosis of Hirschsprung disease using the rectal biopsy: multi-institutional survey. Pediatr Dev Pathol. 1999;2:588–96.PubMedCrossRefGoogle Scholar
  31. 31.
    Koletzko S, Jesch I, Faus-Kessler T, et al. Rectal biopsy for diagnosis of intestinal neuronal dysplasia in children: a prospective multicentre study on interobserver variation and clinical outcome. Gut. 1999;44:853–61.PubMedCrossRefGoogle Scholar
  32. 32.
    Gillick J, Tazawa H, and Puri P. Intestinal neuronal dysplasia: results of treatment in 33 patients. J Pediatr Surg. 2001;36:777–9.PubMedCrossRefGoogle Scholar
  33. 33.
    Chang GJ, Berry MJ, Jay N, Palfsky JM, and Welton ML. Surgical treatment of high-grade anal squamous intraepithelial lesions. A prospective study. Dis Colon Rectum. 2002;45:453–8.PubMedCrossRefGoogle Scholar
  34. 34.
    Jay N, Berry JM, Hogeboom CJ, Holly EA, Darragh TM, and Palefsky JM. Colposcopic appearance of anal squamous intraepithelial lesions. Relationship to histopathology. Dis Colon Rectum. 1997;40:919–28.PubMedCrossRefGoogle Scholar
  35. 35.
    Zbar AP, Fenger C, Efron J, Wexner SD, and Beer-Gabel M. The pathology and molecular biology of anal intraepithelial neoplasia: comparisons with cervical and vulvar intraepithelial carcinoma. Int J Colorectal Dis. 2002;17:203–15.PubMedCrossRefGoogle Scholar
  36. 36.
    Sobhani I, Vuagnat A, Walker F, Vissuzaine C, Mirin B, Hervatin F, Marmuse JP, Cremieux AC, Carbon C, Henin D, Lehy T, and Mignon M. Prevalence of high-grade dysplasia and cancer in the anal canal in human papilloma-virus infected individuals. Gastroenterology. 2001;120:857–66.PubMedCrossRefGoogle Scholar
  37. 37.
    Carter PS, Sheffield JP, Shepherd N, et al. Interobserver variation in the reporting of the histopathological grading of anal intraepithelial neoplasia. J Clin Pathol. 1994;47:1032–4.PubMedGoogle Scholar
  38. 38.
    Byars RW, Poole GV, and Barber WH. Anal carcinoma arising from condyloma acuminata. Am Surg. 2001;67:469–72.PubMedGoogle Scholar
  39. 39.
    Mullerat J, Wong Te Fong LF, Davies SE, Winslet MC, Perrett CW. Angiogenesis in anal warts, anal intraepithelial neoplasia and anal squamous cell carcinoma. Colorectal Dis. 2003;5:353–7.PubMedCrossRefGoogle Scholar
  40. 40.
    Sobhani I, Vuagnat A, Walker F, et al. Prevalence of high-grade dysplasia and cancer in the anal canal in Human Papillomavirus-Infected individuals. Gastroenterol. 2001;120:857–66.CrossRefGoogle Scholar
  41. 41.
    Manzione CR, Nadal SR, and Calore EE. Postoperative follow-up of anal condylomata acuminata in HIV-positive patients. Dis Colon Rectum. 2003;46:1358–65.PubMedCrossRefGoogle Scholar
  42. 42.
    Fenger C, Frisch M, Jass JJ, Williams GT, and Hilden J. Anal cancer subtype reproducibility study. Virchows Arch. 2000;436:229–33.PubMedCrossRefGoogle Scholar
  43. 43.
    Shepherd NA, Scholefield JH, Love SB, England J, and Northover JMA. Prognostic factors in anal squamous carcinoma: a multivariate analysis of clinical, pathological and flow cytometric parameters in 235 cases. Histopathology. 1990;16:545–55.PubMedGoogle Scholar
  44. 44.
    Frisch M, Fenger C, van den Brule AJC, et al. Variants of squamous cell carcinoma of the anal canal and perianal skin and their relation to human papillomaviruses. Cancer Res. 1999;59:753–7.PubMedGoogle Scholar
  45. 45.
    Frisch M. On the etiology of anal squamous carcinoma. Laegeforeningens Forlag. 2002;5–21.Google Scholar
  46. 46.
    Bjørge T, Engeland A, Luostarinen T, et al. Human papillomavirus infection as a risk factor for anal and perianal skin cancer in a prospective study. Br J Cancer. 2002;87:61–4.PubMedCrossRefGoogle Scholar
  47. 47.
    Remzi FH, Fazio VW, Delaney CP, et al. Dysplasia of the anal transitional zone after ileal pouch-anal anastomosis. Results of prospective evaluation after a minimum of ten years. Dis Colon Rectum. 2003;46:6–13.PubMedCrossRefGoogle Scholar
  48. 48.
    Fenger C. Prognostic factors in anal carcinoma. Pathology. 2002;34:573–8.PubMedCrossRefGoogle Scholar
  49. 49.
    Keshtgar MRS, Amin A, Taylor I, and Ell PJ. The sentinel node in anal carcinoma. Euro J Surg Oncol. 2001;27:113–22.CrossRefGoogle Scholar
  50. 50.
    Mistrangelo M, Mobiglia A, Mussa B, et al. The sentinel node in anal carcinoma. Tumori. 2002;88:S51–2.PubMedGoogle Scholar
  51. 51.
    Rabbitt P, Pathma-Nathan N, Collinson T, Hewett P, and Rieger N. Sentinel lymph node biopsy for squamous cell carcinoma of the anal canal. ANZ J Surg. 2002;72:651–4.PubMedCrossRefGoogle Scholar
  52. 52.
    Kuppers F, Jongen J, Bock J-U, and Rabenhorst G. Keratoacanthoma in the differential diagnosis of anal carcinoma: difficult diagnosis, easy therapy. Report of three cases. Dis Colon Rectum. 2000;43:427–9.PubMedCrossRefGoogle Scholar
  53. 53.
    Trombetta LJ and Place RJ. Giant condyloma acuminatum of the anorectum: trends in epidemiology and management. Report of a case and review of the literature. Dis Colon Rectum. 2001;44:1878–86.PubMedCrossRefGoogle Scholar
  54. 54.
    Hobbs CM, Lowry MA, Owen D, and Sobin LH. Anal gland carcinoma. Cancer. 2001;92:2045–9.PubMedCrossRefGoogle Scholar
  55. 55.
    Li SC, Waters BL, Simmonds-Arnold L, and Beatty BG. Cytokeratin 7 and 20 expressions in rectal adenomas, rectal adenocarcinomas, anal glands and functional rectal mucosa. Mod Pathol. 2001;14:90A.CrossRefGoogle Scholar
  56. 56.
    Donati P and Amantea A. Adenoma of anogenital mammary-like glands. Am J Dermatopathol. 1996;18:73–6.PubMedCrossRefGoogle Scholar
  57. 57.
    Nowak MA, Guierrere-Kovach P, Pathan A, Campbelle TE, and Deppisch LM. Perianal Paget’s disease. Distinguishing primary and secondary lesions using immunohistochemical studies including gross cystic disease fluid protein-15 and cytokeratin 20 expression. Arch Pathol Lab Med. 1998;122:1077–81.PubMedGoogle Scholar
  58. 58.
    Ohnishi T and Watanabe S. The use of cytokeratins 7 and 20 in the diagnosis of primary and secondary extrammary Paget’s disease. Br J Dermatol. 2000;142:243–7.PubMedCrossRefGoogle Scholar
  59. 59.
    Val-Bernal JF and Pinto J. Pagetoid dyskeratosis is a frequent finding in hemorrhoidal disease. Arch Pathol Lab Med. 2001:125:1058–62.PubMedGoogle Scholar
  60. 60.
    Krishnan R, Lewis A, Orengo IF, and Rosen T. Pigmented Bowen’s disease (Squamous carcinoma in situ): a mimic of malignant melanoma. Dermatol Surg. 2001;27:673–4.PubMedCrossRefGoogle Scholar
  61. 61.
    Cooper P, Mills SE, and Allen M. Malignant melanoma of the anus: report of 12 patients and analysis of 255 additional cases. Dis Colon Rectum. 1982;25:693–703.PubMedGoogle Scholar
  62. 62.
    Bhama JK, Azad NS, and Fisher WE. Primary anorectal lymphoma presenting as a perianal abscess in an HIV-positive male. Eur J Surg Oncol. 2002;28:195–7.PubMedCrossRefGoogle Scholar
  63. 63.
    Tan GY, Chong CK, Eu KW, and Tan PH. Gastrointestinal stromal tumor of the anus. Tech Coloproctol. 2003;7:169–72.PubMedCrossRefGoogle Scholar
  64. 64.
    Norgren J and Svensson JO. Anal implantation metastasis from carcinoma of the sigmoid colon and rectum: a risk when performing anterior resection with the EEA stapler? Br J Surg. 1985;75:602.Google Scholar
  65. 65.
    Hyman N and Kida M. Adenocarcinoma of the sigmoid colon seeding a chronic anal fistula. Report of a case. Dis Colon Rectum. 2003;46:835–6.PubMedCrossRefGoogle Scholar
  66. 66.
    Onerheim RM. A case of perianal mucinous adenocarcinoma arising in a fistulainano. A clue to the early pathologic diagnosis. Am J Clin Pathol. 1988;89:809–12.PubMedGoogle Scholar
  67. 67.
    Alizai NK, Batcup G, Dixon MF, Stringer MD. Rectal biopsy for Hirschprung’s disease: what is the optimum method? Pediatr Surg Int. 1998;13:121–4.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag London Limited 2005

Authors and Affiliations

  • Claus Fenger
    • 1
  1. 1.Department of PathologyOdense University HospitalDenmark

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