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Hughes Syndrome pp 446–456Cite as

Annexins in Antiphospholipid Syndrome

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Conclusions

In conclusion, annexin A5 is a potent anticoagulant protein that forms an antithrombotic shield over anionic phospholipids containing bilayers. Autoantibodies may interfere with this shielding function via high affinity antibodies that recognize phospholipid binding proteins that are capable of interfering with the assembly of the annexin A5 shield on phospholipid surfaces or via direct recognition of annexin A5 functional epitopes by autoantibodies. Antibody mediated interference with the integrity of the two-dimensional annexin A5 crystal shield may be a mechanism for thrombosis and for pregnancy complications, including recurrent spontaneous pregnancy losses, in APS.

Keywords

  • Annexin Versus
  • Anionic Phospholipid
  • Placental Villus
  • Placental Trophoblast
  • BeWo Cell Line

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Author information

Authors and Affiliations

  1. Department of Pathology and Medicine, Albert Einstein College of Medicine, and Hematology Laboratories, Montefiore Medical Center, Bronx, NY, USA

    Jacob H. Rand MD

  2. Department of Pathology, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA

    Xiao-Xuan Wu MD

Authors
  1. Jacob H. Rand MD
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  2. Xiao-Xuan Wu MD
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Editor information

Editors and Affiliations

  1. Lupus Research Unit, St Thomas’ Hospital, London, UK

    M. A. Khamashta MD, FRCP, PhD (Deputy Head) (Deputy Head)

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© 2006 Springer-Verlag London Limited

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Rand, J.H., Wu, XX. (2006). Annexins in Antiphospholipid Syndrome. In: Khamashta, M.A. (eds) Hughes Syndrome. Springer, London. https://doi.org/10.1007/1-84628-009-5_36

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  • DOI: https://doi.org/10.1007/1-84628-009-5_36

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-85233-873-2

  • Online ISBN: 978-1-84628-009-2

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