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Hughes Syndrome pp 439–445Cite as

Contribution of Tissue Factor to the Pathogenesis of Thrombosis in Patients with Antiphospholipid Syndrome

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Conclusions

Increased TF expression may contribute to thrombosis in patients with APS. This effect might ultimately depend on antibody engagement of PL binding proteins on the monocyte and the EC surface, leading to signal transduction and altered cell activity. Understanding the intracellular mechanism(s) of aPL mediated TF activation may help to establish new therapeutic approaches to revert the prothrombotic state observed in APS patients.

Keywords

  • Vascular Endothelial Growth Factor
  • Tissue Factor
  • Tissue Factor Expression
  • Tissue Factor mRNA
  • Tissue Factor Gene

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Author information

Authors and Affiliations

  1. Research Unit, Reina Sofia Hospital, Córdoba, Spain

    Chary López-Pedrera PhD

  2. Department of Haematology, Reina Sofia Hospital, Córdoba, Spain

    Francisco Velasco MD

  3. Lupus Research Unit, The Rayne Institute, St Thomas’ Hospital, London, UK

    Maria J. Cuadrado MD, PhD

Authors
  1. Chary López-Pedrera PhD
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  2. Francisco Velasco MD
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  3. Maria J. Cuadrado MD, PhD
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Editor information

Editors and Affiliations

  1. Lupus Research Unit, St Thomas’ Hospital, London, UK

    M. A. Khamashta MD, FRCP, PhD (Deputy Head) (Deputy Head)

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© 2006 Springer-Verlag London Limited

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López-Pedrera, C., Velasco, F., Cuadrado, M.J. (2006). Contribution of Tissue Factor to the Pathogenesis of Thrombosis in Patients with Antiphospholipid Syndrome. In: Khamashta, M.A. (eds) Hughes Syndrome. Springer, London. https://doi.org/10.1007/1-84628-009-5_35

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  • DOI: https://doi.org/10.1007/1-84628-009-5_35

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-85233-873-2

  • Online ISBN: 978-1-84628-009-2

  • eBook Packages: MedicineMedicine (R0)

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