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Hughes Syndrome pp 329–337Cite as

Antiphospholipid Syndrome in the Absence of Standard Antiphospholipid Antibodies: Associations with Other Autoantibodies

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Summary

Certain autoantibodies not detected in standard aCL and LA assays may be associated with clinical manifestations of APS. These antibodies are not included in the current serological criteria for the classification of definite APS, although these criteria are likely to be expanded in the future. Autoantibodies to β2-GPI and prothrombin, detected in protein-based ELISAs, are likely candidates for consideration. At the present time antibodies detected in ELISAs using anionic phospholipids other than cardiolipin are of possible interest, however, evidence for the clinical utility of such assays is weak. Future studies elucidating the specificity of these antibodies and inter-laboratory efforts toward assay standardization are needed. Antibodies detected in anti-phosphatidylethanolamine assays may be associated with clinical features of APS and may directly contribute to a prothrombotic state.

In conclusion, certain patients with clinical features of APS may have 1 or more of the autoantibodies discussed above, in the absence of aCL or LA. While these patients do not meet current classification criteria for definite APS, conceptually they may be included in a broader clinical view of autoantibody-mediated thrombosis and pregnancy loss.

Keywords

  • Systemic Lupus Erythematosus
  • Recurrent Pregnancy Loss
  • Anticardiolipin Antibody
  • Anionic Phospholipid
  • Lupus Anticoagulant Test

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Authors and Affiliations

  1. Division of Rheumatology, Allergy & Immunology, Department of Medicine, and Thurston Arthritis Research Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

    Robert A. S. Roubey MD

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Editors and Affiliations

  1. Lupus Research Unit, St Thomas’ Hospital, London, UK

    M. A. Khamashta MD, FRCP, PhD (Deputy Head) (Deputy Head)

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Roubey, R.A.S. (2006). Antiphospholipid Syndrome in the Absence of Standard Antiphospholipid Antibodies: Associations with Other Autoantibodies. In: Khamashta, M.A. (eds) Hughes Syndrome. Springer, London. https://doi.org/10.1007/1-84628-009-5_27

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  • DOI: https://doi.org/10.1007/1-84628-009-5_27

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