Keywords
- Systemic Lupus Erythematosus
- Pulmonary Embolism
- Pulmonary Hypertension
- Systemic Lupus Erythematosus Patient
- Anticardiolipin Antibody
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References
Gosney JR. Pulmonary hypertension. In: Halliday, Hunt, Poston, Schachter, eds. An introduction to vascular biology. Cambridge: Cambridge University Press; 1998:100–111.
Galie N, Manes A, Uguccioni L, et al. Primary pulmonary hypertension: insights into pathogenesis from epidemiology. Chest 1998;114(suppl 3):184S–194S.
Haworth SG. Primary pulmonary hypertension. J R Coll Physicians Lond 1998;32:187–190.
Lee SD, Shroyer KR, Markham NE, Cool CD, Voelkel NF, Tuder RM. Monoclonal endothelial cell proliferation is present in primary but not secondary pulmonary hypertension. J Clin Invest 1998;101:927–934.
Mecham RP. Conference summary: biology and pathobiology of the lung circulation. Chest 1998;114(suppl 3):106S–111S.
Voelkel NF, Cool C, Lee SD, Wright L, Geraci MW, Tuder RM. Primary pulmonary hypertension between inflammation and cancer. Chest 1998;114(suppl 3):225S–230S.
Fishman AP. Etiology and pathogenesis of primary pulmonary hypertension: a perspective. Chest 1998;114(suppl 3):242S–247S.
Chaouat A, Weitzenblum E, Higenbottam T. The role of thrombosis in severe pulmonary hypertension. Eur Respir J 1996;9:356–363.
Cool CD, Rai PR, Yeager ME, et al. Expression of human herpsevirus 8 in primary pulmonary hypertension. N Engl J Med 2003;349:1113–1122.
The International PPH Consortium. Heterozygous germline mutations in BMPR2, encoding a TGF-β receptor, cause familia primary pulmonary hypertension. Nat Genet 2000;26:81–84.
Du L, Sullivan CC, Chu D, et al. Signaling molecules in nonfamilial pulmonary hypertension. N Engl J Med 2003;348:500–509.
Piette JC. 1996 diagnostic and classification criteria for the antiphospholipid/cofactors syndrome: a “mission impossible”? Lupus 1996;5:354–363.
Vianna JL, Khamashta MA, Ordi-Ros J, et al. Comparison of the primary and secondary antiphospholipid syndrome: a European multicenter study of 114 patients. Am J Med 1994;96:3–9.
Alarcon-Segovia D, Perez-Vazquez ME, Villa AR, Drenkard C, Cabiedes J. Preliminary classification criteria for the antiphospholipid syndrome within systemic lupus erythematosus. Semin Arthritis Rheum 1992;21:275–286.
Asherson RA, Higenbottam TW, Dinh Xuan AT, Khamashta MA, Hughes GRV. Pulmonary hypertension in a lupus clinic: experience with twenty-four patients. J Rheumatol 1990;17:1292–1298.
Koike T, Tsutsumi A. Pulmonary hypertension and the antiphospholipid syndrome. Intern Med 1995;34:938.
Kunieda T. Antiphospholipid syndrome and pulmonary hypertension. Intern Med 1996;35:842–843.
Asherson RA, Khamashta MA, Ordi-Ros J, et al. The “primary” antiphospholipid syndrome: major clinical and serological features. Medicine (Baltimore) 1989;68:366–374.
Font J, Lopez-Soto A, Cervera R, et al. The “primary” antiphospholipid syndrome: antiphospholipid antibody pattern and clinical features of a series of 23 patients. Autoimmunity 1991;9:69–75.
Asherson RA, Cervera R, Piette JC, et al. “Catastrophic” antiphospholipid syndrome: clinical and laboratory features of 50 patients. Medicine (Baltimore) 1998;77:195–207.
Cervera R, Garcia-Carrasco M, Asherson RA. Pulmonary manifestations in the antiphospholipid syndrome. In: Asherson RA, Cervera R, Piette JC, Shoenfeld Y, eds. The antiphospholipid syndrome. Boca Raton: CRC Press; 1996:161–167.
Mintz G, Acevedo-Vazquez E, Guttierrez-Espinosa G, Avelar-Garnica F. Renal vein thrombosis and inferior vena cava thrombosis in systemic lupus erythematosus. Arthritis Rheum 1984;27:539–544.
Brucato A, Baudo F, Barberis M, et al. Pulmonary hypertension secondary to thrombosis of the pulmonary vessels in a patient with the primary antiphospholipid syndrome. J Rheumatol 1994;21:942–944.
Day SM, Rosenzweig BP, Kronzon I. Transesophageal echocardiographic diagnosis of right atrial thrombi associated with the antiphospholipid syndrome. J Am Soc Echocardiogr 1995;8:937–940.
O’Hickey S, Skinner C, Beattie J. Life-threatening right ventricular thrombosis in association with phospholipid antibodies. Br Heart J 1993;70:279–281.
Ginsburg KS, Liang MH, Newcomer L, et al. Anticardiolipin antibodies and the risk for ischemic stroke and venous thrombosis. Ann Intern Med 1992;117:997–1002.
Schulman S, Svenungsson E, Granqvist S, and the Duration of Anticoagulation Study Group. Anticardiolipin antibodies predict early recurrence of thromboembolism and death among patients with venous thromboembolism following anticoagulant therapy. Am J Med 1998;104:332–338.
Kearon C, Gent M, Hirsh J, et al. A Comparison of three months of anticoagulation with extended anticoagulation for a first episode of idiopathic venous thromboembolism. N Engl J Med 1999;340:901–907.
Anderson NE, Ali MR. The lupus anticoagulant, pulmonary thromboembolism, and fatal pulmonary hypertension. Ann Rheum Dis 1984;43:760–763.
Sandoval J, Amigo MC, Barragan R, et al. Primary antiphospholipid syndrome presenting as chronic thromboembolic pulmonary hypertension. Treatment with thromboendarterectomy. J Rheumatol 1996;23:772–775.
Ando M, Takamoto S, Okita Y, et al. Operation for chronic pulmonary thromboembolism accompanied by thrombophilia in 8 patients. Ann Thorac Surg 1998;66:1919–1924.
Miyashita Y, Koike H, Misawa A, Shimizu H, Yoshida K, Yasutomi T. Asymptomatic pulmonary hypertension complicated with antiphospholipid syndrome case. Intern Med 1996;35:912–915.
Jeffrey PJ, Asherson RA, Rees PJ. Recurrent deep vein thrombosis, thromboembolic pulmonary hypertension and the “primary” antiphospholipid syndrome. Clin Exp Rheumatol 1989;7:567–569.
Rosner S, Ginzler EM, Diamond HS, et al. A multicenter study of outcome in systemic lupus erythematosus. II. Causes of death. Arthritis Rheum 1982;25:612–617.
Khamashta MA, Cervera R, Asherson RA, et al. Association of antibodies against phospholipids with heart valve disease in systemic lupus erythematosus. Lancet 1990;335:1541–1544.
Cervera R, Khamashta MA, Font J, et al. High prevalence of significant heart valve lesions in patients with the “primary” antiphospholipid syndrome. Lupus 1991;1:43–47.
Hojnik M, George J, Ziporen L, Shoenfeld Y. Heart valve involvement (Libman-Sacks endocarditis) in the antiphospholipid syndrome. Circulation 1996;93:1579–1587.
Roldan CA, Shively BK, Crawford MH. An echocardiographic study of valvular heart disease associated with systemic lupus erythematosus. N Engl J Med 1996;335:1424–1430.
Nesher G, Ilany J, Rosenmann D, Abraham AS. Valvular dysfunction in antiphospholipid syndrome: prevalence, clinical features, and treatment. Semin Arthritis Rheum 1997;27:27–35.
Piette JC, Amoura Z, Papo T. Valvular heart disease and systemic lupus erythematosus [letter]. N Engl J Med 1997;336:1324.
Asherson RA, Khamashta MA, Baguley E, Oakley CM, Rowell NR, Hughes GRV. Myocardial infarction and antiphospholipid antibodies in SLE and related disorders. Q J Med 1989;73:1103–1115.
Kattwinkel N, Villanueva AG, Labib SB, et al. Myocardial infarction caused by cardiac microvasculopathy in a patient with the primary antiphospholipid syndrome. Ann Intern Med 1992;116:974–976.
Nihoyannopoulos P, Gomez PM, Joshi J, Loizou S, Walport MJ, Oakley CM. Cardiac abnormalities in systemic lupus erythematosus: association with raised anticardiolipin antibodies. Circulation 1990;82:369–375.
De Clerck LS, Michielsen PP, Ramael MR, et al. Portal and pulmonary vessel thrombosis associated with systemic lupus erythematosus and anticardiolipin antibodies. J Rheumatol 1991;18:1919–1921.
Hussein A, Trowitzsch E, Brockmann M. Pulmonary veno-occlusive disease, antiphospholipid antibody and pulmonary hypertension in an adolescent. Klin Padiatr 1999;211:92–95.
Pengo V, Lensing AWA, Prins MH, et al. Incidence of chronic thromboembolic pulmonary hypertension after pulmonary embolism. N Engl J Med 2004;350:2257–2264.
Fedullo PF, Auger WR, Kerr KM, Rubin LJ. Chronic thromboembolic pulmonary hypertension. N Engl J Med 2001;345:1465–1472.
Jamieson SW, Kapelanski DP, Sakakibara N, et al. Pulmonary endarterectomy: experience and lessons learned in 1,500 cases. Ann Thorac Surg 2003;76:1457–1464.
Merkel PA, Chang YC, Pierangeli SS, Convery K, Harris EN, Polisson RP. The prevalence and clinical associations of anticardiolipin antibodies in a large inception cohort of patients with connective tissue diseases. Am J Med 1996;101:576–583.
Burdt MA, Hoffman RW, Deutscher SL, Wang GS, Johnson JC, Sharp GC. Long-term outcome in mixed connective tissue disease: longitudinal clinical and serologic findings. Arthritis Rheum 1999;42:899–909.
Asherson RA, Mackworth-Young CG, Boey ML, et al. Pulmonary hypertension in systemic lupus erythematosus. Br Med J 1983;287:1024–1025.
Alarcon-Segovia D, Deleze M, Oria CV, et al. Antiphospholipid antibodies and the antiphospholipid syndrome in systemic lupus erythematosus. A prospective analysis of 500 consecutive patients. Medicine (Baltimore) 1989;68:353–365.
Alarcon-Segovia D. Clinical manifestations of the antiphospholipid syndrome. J Rheumatol 1992;19:1778–1781.
Sturfelt G, Eskilsson J, Nived O, Truedsson L, Valind S. Cardiovascular disease in systemic lupus erythematosus. A study of 75 patients from a defined population. Medicine (Baltimore) 1992;71:216–223.
Petri M, Rheinschmidt M, Whiting-O’Keefe Q, Hellmann D, Corash L. The frequency of lupus anticoagulant in systemic lupus erythematosus. A study of sixty consecutive patients by activated partial thromboplastin time, Russell viper venom time, and anticardiolipin antibody level. Ann Intern Med 1987;106:524–531.
Miyata M, Suzuki K, Sakuma F, et al. Anticardiolipin antibodies are associated with pulmonary hypertension in patients with mixed connective tissue disease or systemic lupus erythematosus. Int Arch Allergy Immunol 1993;100:351–354.
Biyajima S, Osada T, Daidoji H, et al. Pulmonary hypertension and antiphospholipid antibody in a patient with Sjögren’s syndrome. Intern Med 1994;33:768–772.
Tilley S, Newman J, Thomas A. Antiphospholipid and anticentromere antibodies occurring together in a patient with pulmonary hypertension. Tenn Med 1996;89:166–168.
Luchi ME, Asherson RA, Lahita RG. Primary idiopathic pulmonary hypertension complicated by pulmonary arterial thrombosis. Association with antiphospholipid antibodies. Arthritis Rheum 1992;35:700–705.
De la Mata J, Gomez-Sanchez MA, Aranzana M, Gomez-Reino JJ. Long-term iloprost infusion therapy for severe pulmonary hypertension in patients with connective tissue diseases. Arthritis Rheum 1994;37:1528–1533.
Nagai H, Yasuma K, Katsuki T, et al. Primary antiphospholipid syndrome and pulmonary hypertension with prolonged survival. A case report. Angiology 1997;48:183–187.
Rich S, Kieras K, Hart K, Groves BM, Stobo JD, Brundage BH. Antinuclear antibodies in primary pulmonary hypertension. J Am Coll Cardiol 1986;8:1307–1311.
Isern RA, Yaneva M, Weiner E, et al. Autoantibodies in patients with primary pulmonary hypertension: association with anti-Ku. Am J Med 1992;93:307–312.
Martinuzzo ME, Pombo G, Forastiero RR, Cerrato GS, Colorio CC, Carreras LO. Lupus anticoagulant, high levels of anticardiolipin, and anti-beta2-glycoprotein I antibodies are associated with chronic thromboembolic pulmonary hypertension. J Rheumatol 1998;25:1313–1319.
Wolf M, Boyer-Neumann C, Parent F, et al. Thrombotic risk factors in pulmonary hypertension. Eur Respir J 2000;15:395–399.
Auger WR, Permpikul P, Moser KM. Lupus anticoagulant, heparin use, and thrombocytopenia in patients with chronic thromboembolic pulmonary hypertension: a preliminary report. Am J Med 1995;99:392–396.
Karmochkine M, Cacoub P, Dorent R, et al. High prevalence of antiphospholipid antibodies in precapillary pulmonary hypertension. J Rheumatol 1996;23:286–290.
Wilson WA, Gharavi AE, Koike T, et al. International consensus statement on preliminary classification criteria for definite antiphospholipid syndrome: report of an international workshop. Arthritis Rheum 1999;42:1309–1311.
Opravil M, Pechere M, Speich R, et al. HIV-associated primary pulmonary hypertension. A case control study. Swiss HIV Cohort Study. Am J Respir Crit Care Med 1997;155:990–995.
Cacoub P, Dorent R, Nataf P, et al. Endothelin-1 in the lungs of patients with pulmonary hypertension. Cardiovasc Res 1997;33:196–200.
Atsumi T, Khamashta MA, Haworth RS, et al. Arterial disease and thrombosis in the antiphospholipid syndrome: a pathogenic role for endothelin 1. Arthritis Rheum 1998;41:800–807.
Yoshio T, Masuyama J, Sumiya M, Minota S, Kano S. Antiendothelial cell antibodies and their relation to pulmonary hypertension in systemic lupus erythematosus. J Rheumatol 1994;21:2058–2063.
Yoshio T, Masuyama J, Mimori A, Takeda A, Minota S, Kano S. Endothelin-1 release from cultured endothelial cells induced by sera from patients with systemic lupus erythematosus. Ann Rheum Dis 1995;54:361–365.
Prandoni P, Lensing A, Büller HR, et al. Deep-vein thrombosis and the incidence of subsequent symptomatic cancer. N Engl J Med 1992;327:1128–1133.
Zuckerman E, Toubi E, Golan TD, et al. Increased thromboembolic incidence in anti-cardiolipinpositive patients with malignancy. Br J Cancer 1995;72:447–451.
Ruffatti A, Aversa S, Del Ross T, Tonetto S, Fiorentino M, Todesco S. Antiphospholipid antibody syndrome associated with ovarian cancer. A new paraneoplastic syndrome? J Rheumatol 1994;21:2162–2163.
Papagiannis A, Cooper A, Banks J. Pulmonary embolism and lupus anticoagulant in a woman with renal cell carcinoma. J Urol 1994;152:941–942.
Hibbert M, Braude S. Tumour microembolism presenting as “primary pulmonary hypertension”. Thorax 1997;52:1016–1017.
Piette JC, Cacoub P. Antiphospholipid syndrome in the elderly: caution [editorial]. Circulation 1998;97:2195–2196.
Humbert M, Sanchez O, Fartoukh M, Jagot JL, Sitbon O, Simonneau G. Treatment of severe pulmonary hypertension secondary to connective tissue diseases with continuous IV epoprostenol (prostacyclin). Chest 1998;114:80S–82S.
Groen H, Bootsma H, Postma DS, Kallenberg CGM. Primary pulmonary hypertension in a patient with systemic lupus erythematosus: partial improvement with cyclophosphamide. J Rheumatol 1993;20:1055–1057.
Tam LS, Li EK. Successful treatment with immunosuppression, anticoagulation and vasodilator therapy of pulmonary hypertension in SLE associated with secondary antiphospholipid syndrome. Lupus 1998;7:495–497.
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Piette, JC., Hunt, B.J. (2006). Pulmonary Hypertension and Antiphospholipid Antibodies. In: Khamashta, M.A. (eds) Hughes Syndrome. Springer, London. https://doi.org/10.1007/1-84628-009-5_11
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DOI: https://doi.org/10.1007/1-84628-009-5_11
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