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Somatostatin pp 107-121 | Cite as

Expression of Somatostatin Receptors in Human Tissues in Health and Disease

  • Jean Claude Reubi
  • Beatrice Waser
  • Jean-Claude Schaer
Chapter
Part of the Endocrine Updates book series (ENDO, volume 24)

Conclusions

The knowledge of SSTR expression in tumors and normal tissues is a prerequisite for clinical investigations with somatostatin analogs. Indeed, the high expression of SSTRs in tumors represents the molecular basis for novel diagnostical and radiotherapeutical applications of somatostatin analogs (67, 68). Moreover, the presence of SSTRs may, in some instances, such as neuroblastomas, represent a good prognostic factor for patient survival (69, 70), while the absence of receptors is related to early death. Furthermore, the absence of SSTRs, such as sst2 in pancreatic cancers, may represent a significant growth advantage to these tumors (17). One of the main challenges for the future will be to unravel the various physiological and pathophysiological roles of somatostatin mediated by SSTR subtypes, and identify potential therapeutical indications for the newly developed subtypeselective somatostatin analogs (27–29).

Keywords

Pituitary Adenoma Receptor Autoradiography Vasoactive Intestinal Peptide Receptor Gastroenteropancreatic Tumor Peritumoral Vessel 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science + Business Media, Inc. 2004

Authors and Affiliations

  • Jean Claude Reubi
    • 1
  • Beatrice Waser
    • 1
  • Jean-Claude Schaer
    • 1
  1. 1.Division of Cell Biology and Experimental Cancer Research, Institute of PathologyUniversity of BerneSwitzerland

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