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Metabolic Actions of Ghrelin

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Book cover Ghrelin

Part of the book series: Endocrine Updates ((ENDO,volume 23))

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Abstract

Ghrelin is mainly expressed in the stomach, followed by lower parts of the gastrointestinal tract, Ghrelin secretion is mainly influenced by changes in energy balance and glucose homeostasis, followed by alterations of endocrine axes. Ghrelin therefore seems to be an interface between energy homeostasis, glucose metabolism and physiological processes regulated by the classical endocrine axes that e.g., control growth. Ghrelin most likely defends fat mass to ensure survival and to provide the calories that are needed for growth hormone to act on growth and repair. The possibility of using a ghrelin antagonist for the treatment of obesity initiated a hunt for such a valuable agent. It will not be long before antagonists are disclosed and tested for the treatment of obesity.

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  1. Department of Internal Medicine, Section of Endocrinology, Erasmus MC, Rotterdam, The Netherlands

    Carlotta Gauna & Aart Jan van der Lely

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  1. Carlotta Gauna
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Editors and Affiliations

  1. Division of Endocrinology and Metabolism Department of Internal Medicine, University of Turin, Italy

    Ezio Ghigo , Andrea Benso  & Fabio Broglio ,  & 

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Gauna, C., van der Lely, A.J. (2004). Metabolic Actions of Ghrelin. In: Ghigo, E., Benso, A., Broglio, F. (eds) Ghrelin. Endocrine Updates, vol 23. Springer, Boston, MA. https://doi.org/10.1007/1-4020-7971-0_11

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