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Nitric Oxide, Cell Death, and Heart Failure

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Book cover The Role of Nitric Oxide in Heart Failure

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Abstract

Strong evidence links cardiomyocyte loss to the pathology of some forms of heart failure. Both necrotic and apoptotic modes of cell death have been invoked as the mechanism underlying progressive cardiomyocyte dropout. Nitric oxide (NO) has received particular attention as a candidate reactive oxygen intermediate that influences not only cardiac function, but also cell death elicited by both apoptotic and necrotic mechanisms. NO is produced by resident cardiac cells under stress, and is produced in large quantities by activated immune cells that infiltrate the injured heart. A review of the literature, however, reveals that the actions of NO on apoptotic cell death are complex, especially in the context of heart disease, and that the practical contribution of NO to cell death in heart disease is yet to be defined.

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Authors and Affiliations

  1. Cardiovascular Division, Brigham and Women’s Hospital, Boston, MA, USA

    Jun-ichi Oyama MD, Charles Blais Jr. PhD & Todd Bourcier PhD

  2. Genzyme Corporation, 15 Pleasant Street Connector, PO Box 9322, Framingham, MA, 01701-9322, USA

    Ralph A. Kelly MD

  3. Medizinische Universitätsklinik Würzburg, Wüzburg, Germany

    Stefan Frantz MD

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  1. Jun-ichi Oyama MD
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  2. Stefan Frantz MD
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  5. Todd Bourcier PhD
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Editors and Affiliations

  1. Cardiology Division Department of Medicine, University of Alberta, Edmonton, Alberta, Canada

    Bodh I. Jugdutt

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Oyama, Ji., Frantz, S., Blais, C., Kelly, R.A., Bourcier, T. (2004). Nitric Oxide, Cell Death, and Heart Failure. In: Jugdutt, B.I. (eds) The Role of Nitric Oxide in Heart Failure. Springer, Boston, MA. https://doi.org/10.1007/1-4020-7960-5_8

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  • DOI: https://doi.org/10.1007/1-4020-7960-5_8

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