Computerized Ultrasound Risk Evaluation (CURE): First Clinical Results

  • N. Duric
  • P. Littrup
  • O. Rama
  • E. Holsapple
Part of the Acoustical Imaging book series (ACIM, volume 28)

Abstract

The Karmanos Cancer Institute has developed an ultrasound (US) tomography system, known as Computerized Ultrasound Risk Evaluation (CURE), for detecting and evaluating breast cancer, with the eventual goal of providing improved differentiation of benign masses from cancer. We report on our first clinical findings with CURE.

A preliminary study imaged 19 patients with CURE between October 1 and December 1, 2004. Patients were recruited on the basis of having a suspicious mass after mammography and follow-up ultrasound. The CURE exam was interposed between the standard US exam and subsequent biopsy. Biopsy results were therefore available for all 19 patients. Typically, 45 tomograms were taken of each patient with the CURE device. For each tomogram, images of reflectivity and sound speed were made with automated algorithms. In five cases, attenuation images had to be produced by a manual technique due to gain instability of the current transducer ring.

Based on the preliminary CURE data we have currently utilized six CURE diagnostic criteria for cancer. In this small sample, when each criterion is given equal weight, it appears that women with higher scores are more likely to have cancerous masses. More definitive results await the conclusion of a larger, ongoing study

Key words

Ultrasound tomography breast cancer diagnostic criteria tissue characterization 

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Copyright information

© Springer 2007

Authors and Affiliations

  • N. Duric
    • 1
  • P. Littrup
    • 1
  • O. Rama
    • 1
  • E. Holsapple
    • 1
  1. 1.Karmanos Cancer InstituteDetroitUSA

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