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Immunology of Fungal Infections pp 383–407Cite as

Immunology of infections with Cryptococcus neoformans

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Abstract

Cryptococcus neoformans is largely an opportunist, causing infection when host defences are breached. During the past two decades, invasive cryptococcal infections have emerged as a major threat to these immunocompromised hosts, especially to non-treated HIV patients. Also patients with neoplastic diseases are at significant risk for infections as a result of their underlying illness and its therapy. The outcome of infections differs, depending upon which aspect of immunity is impaired. This article reviews the current understanding of the role and relative importance of innate and adaptive immunity to Cryptococcus neoformans. An understanding of the host response to this organism is important in decisions regarding use of currently available anti-fungal strategies and in the design of new therapeutic modalities.

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Authors and Affiliations

  1. Department of Internal Medicine & Infectious Diseases, University Medical Center, PO Box 85500, F02.126, 3508 GA Utrecht, The Netherlands

    Pauline Ellerbroek (Dr.), Andy Hoepelman (Prof.) & Frank Coenjaerts (Dr.)

  2. Department of Experimental Medicine, Microbiology Section, University of Perugia, Via del Giochetto, 06122 Perugia, Italy

    Anna Vecchiarelli (Prof.)

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  1. Pauline Ellerbroek
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  2. Anna Vecchiarelli
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  3. Andy Hoepelman
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  4. Frank Coenjaerts
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Editors and Affiliations

  1. University of Cape Town, Cape Town, South Africa

    Gordon D. Brown

  2. Radboud University Nijmegen, Nijmegen, The Netherlands

    Mihai G. Netea

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Ellerbroek, P., Vecchiarelli, A., Hoepelman, A., Coenjaerts, F. (2007). Immunology of infections with Cryptococcus neoformans. In: Brown, G.D., Netea, M.G. (eds) Immunology of Fungal Infections. Springer, Dordrecht. https://doi.org/10.1007/1-4020-5492-0_17

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