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Prokaryotic Systems Biology

  • Chapter
Systems Biology

Part of the book series: Cell Engineering ((CEEN,volume 5))

Abstract

Prokaryotic systems biology is a holistic biological approach that enables comprehensive understanding of an organism. However, two opposing strategies have been proposed to attain such understanding: the top-down and bottom-up approaches. Here we present a review of the current status of the prokaryotic systems biology field against the backdrop of the top-down vs. bottom-up debate, including such topics as current experimental and computational methods and recent literature findings. We use four prokaryotic model systems as examples, including E. coli, Caulobacter crescentus, Halobacterium NRC-1, and Helicobacter pylori. We posit that systems biology programs which pursue an integrated combination of both approaches will be the most successful in attaining comprehensive systems-level understanding of prokaryotic model organisms

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Authors and Affiliations

  1. Institute for Systems Biology, 1441 N 3415st, Seatlle, WA 98103, USA

    Amy K. Schmid & Nitin S. Baliga

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  1. Amy K. Schmid
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  2. Nitin S. Baliga
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Editors and Affiliations

  1. University College Dublin, Ireland

    Mohamed Al-Rubeai

  2. Swiss Federal Institute of Technology, ETH Hoenggeerberg HCI Institute of Chemical and Bioengineering ICB, Zurich, Switzerland

    Martin Fussenegger

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Schmid, A.K., Baliga, N.S. (2007). Prokaryotic Systems Biology. In: Al-Rubeai, M., Fussenegger, M. (eds) Systems Biology. Cell Engineering, vol 5. Springer, Dordrecht. https://doi.org/10.1007/1-4020-5252-9_12

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