Advertisement

Taking Equipoise Seriously: The Failure of Clinical or Community Equipoise to Resolve the Ethical Dilemmas in Randomized Clinical Trials

  • Fred Gifford
Part of the Philosophy and Medicine book series (PHME, volume 90)

Keywords

Policy Decision Clinical Question Theoretical Question Clinical Equipoise Interim Data 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Boyle P (1998) Getting doctors to listen: ethics and outcomes data in context. Georgetown University Press, Washington, D.C.Google Scholar
  2. Crouch R, Arras J (1998) AZT Trials and Tribulations. Hastings Center Report 28(6):26–34CrossRefGoogle Scholar
  3. Freedman B (1987) Equipoise and the ethics of clinical research. N Engl J Med 317:141–145CrossRefGoogle Scholar
  4. Freedman B (1990) Placebo-controlled trials and the logic of clinical purpose. IRB 12(6):1–6CrossRefGoogle Scholar
  5. Freedman B (1992) A response to a purported ethical difficulty with randomized clinical trials involving cancer patients. J Clin Ethics 3:231–234Google Scholar
  6. Fried C (1974) Medical experimentation: Personal integrity and social policy. North-Holland Publishing, AmsterdamGoogle Scholar
  7. Gifford F (1986) The conflict between randomized clinical trials and the therapeutic obligation. J Med Philos 11:347–366Google Scholar
  8. Gifford F (1995) Community equipoise and the ethics of randomized clinical trials. Bioethics 9:127–148Google Scholar
  9. Gifford F (2000) Freedman’s clinical equipoise and sliding-scale all-dimensions considered equipoise. J Med Philos 25:399–426CrossRefGoogle Scholar
  10. Hellman S, Hellman DS (1991) Of mice but not men. N Engl J Med 324:1585–1589CrossRefGoogle Scholar
  11. Lurie P, Wolfe S (1997) Unethical trials of interventions to reduce perinatal transmission of the human immunodeficiency virus in developing countries. N Engl J Med 337:853–856CrossRefGoogle Scholar
  12. Marquis D (1983) Leaving therapy to chance. Hastings Center Report 13(4):40–47CrossRefGoogle Scholar
  13. Miller P, Weijer C (2003) Rehabilitating Equipoise. Kennedy Institute of Ethics Joumal 13:93–118CrossRefGoogle Scholar
  14. Rudner R (1953) The scientist qua scientist makes value judgments. Philosophy of Science 20:1–6CrossRefGoogle Scholar
  15. Weijer, Shapiro, Glass, Enkin (2000) For and against: Clinical equipoise and not the uncertainty principle is the moral underpinning of the randomized controlled trial. Br Med J 321:756–758CrossRefGoogle Scholar
  16. Varmus H, Satcher D (1997) Ethical complexities of conducting research in developing countries. N Engl J Med 337:1003–1005CrossRefGoogle Scholar

Copyright information

© Springer 2007

Authors and Affiliations

  • Fred Gifford

There are no affiliations available

Personalised recommendations