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Biological causes of aging and age-related diseases

  • Chapter
Prevention and Treatment of Age-related Diseases

Abstract

Aging is a progressive accumulation of molecular damage in nucleic acids, proteins and lipids. The inefficiency and failure of maintenance, repair and turnover pathways is the main cause of age-related accumulation of damage, which is also the basis of all age-related diseases. Research in molecular gerontology is aimed at understanding the genetic and epigenetic regulation of molecular mechanisms at the levels of transcription, post-transcriptional processing, post-translational modifications, and interactions among various gene products. Concurrently, several approaches are being tried and tested to modulate aging. The ultimate aim of such studies is to improve the quality of human life in old age and prolong the health-span. Various gerontomodulatory approaches include gene therapy, hormonal supplementation, nutritional modulation and intervention by free radical scavengers and other molecules. A recent approach is that of applying hormesis in aging research and therapy, which is based on the principle of stimulation of maintenance and repair pathways by repeated exposure to mild stress. A combination of molecular, physiological and psychological modulatory approaches can be effective to prevent and/or treat various age-related diseases

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  1. Laboratory of Cellular Ageing, Danish Centre for Molecular Gerontology, Department of Molecular Biology, University of Aarhus, Denmark

    Suresh I.S. Rattan

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  1. Danish Centre for Molecular Gerontology, University of Aarhus, Denmark

    Suresh I.S. Rattan

  2. University Hospital of Odense, Denmark

    Moustapha Kassem

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Rattan, S.I. (2006). Biological causes of aging and age-related diseases. In: Rattan, S.I., Kassem, M. (eds) Prevention and Treatment of Age-related Diseases. Springer, Dordrecht. https://doi.org/10.1007/1-4020-5058-5_1

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