Abstract
Canonical transcriptional responses to transforming growth factor-β (TGF-β) superfamily members occur via rapid nuclear translocation of cytoplasmic proteins of the Smad family, which are activated by ligand-activated membrane-bound heteromeric serine-threonine kinase receptor complexes. Smad-driven gene expression is strongly dependent upon interactions of with other intracellular signaling mechanisms, initiated or not by TGF-β itself, that may potentiate, synergize, or antagonize, the TGF-β/Smad pathway. Among pathways identified to modulate Smad responses are mitogen-activated protein kinases (MAPKs), a large family of kinases involved in the transmission of diverse extracellular signals from the plasma membrane to the cell nucleus. In this chapter, we describe how MAPKs modify the outcome of Smad activation by TGF-β, and how crosstalk mechanisms between the Smad and MAPK pathways take place and affect cellular behavior and TGF-β target gene expression
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Javelaud, D., Mauviel, A. (2006). Interplays Between The Smad and Map Kinase Signaling Pathways. In: Dijke, P.t., Heldin, CH. (eds) Smad Signal Transduction. Proteins and Cell Regulation, vol 5. Springer, Dordrecht. https://doi.org/10.1007/1-4020-4709-6_16
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