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Interplays Between The Smad and Map Kinase Signaling Pathways

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Book cover Smad Signal Transduction

Part of the book series: Proteins and Cell Regulation ((PROR,volume 5))

Abstract

Canonical transcriptional responses to transforming growth factor-β (TGF-β) superfamily members occur via rapid nuclear translocation of cytoplasmic proteins of the Smad family, which are activated by ligand-activated membrane-bound heteromeric serine-threonine kinase receptor complexes. Smad-driven gene expression is strongly dependent upon interactions of with other intracellular signaling mechanisms, initiated or not by TGF-β itself, that may potentiate, synergize, or antagonize, the TGF-β/Smad pathway. Among pathways identified to modulate Smad responses are mitogen-activated protein kinases (MAPKs), a large family of kinases involved in the transmission of diverse extracellular signals from the plasma membrane to the cell nucleus. In this chapter, we describe how MAPKs modify the outcome of Smad activation by TGF-β, and how crosstalk mechanisms between the Smad and MAPK pathways take place and affect cellular behavior and TGF-β target gene expression

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Authors and Affiliations

  1. INSERM, U697, Université Paris 7-Denis Diderot, Faculté de médecine Hôpital Saint-Louis, 1 avenue Claude Vellefaux, 75010 Paris, France

    Delphine Javelaud & Alain Mauviel

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  1. Delphine Javelaud
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  2. Alain Mauviel
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  1. Leiden University Medical Center, Leiden, The Netherlands

    Peter ten Dijke

  2. Ludwig Institute for Cancer Research, Uppsala University, Sweden

    Carl-Henrik Heldin

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© 2006 Springer

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Javelaud, D., Mauviel, A. (2006). Interplays Between The Smad and Map Kinase Signaling Pathways. In: Dijke, P.t., Heldin, CH. (eds) Smad Signal Transduction. Proteins and Cell Regulation, vol 5. Springer, Dordrecht. https://doi.org/10.1007/1-4020-4709-6_16

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