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Comparison of the Effects of Ras Effector Mutants and Ras Effectors on Transformed and Tumorigenic Growth of Human and Rodent Cells

  • Chapter
RAS Family GTPases

Part of the book series: Proteins and Cell Regulation ((PROR,volume 4))

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Abstract

How oncogenic Ras signaling leads to transformation of normal cells to malignant state has been under intense scrutiny over the last few decades. It is now well-appreciated that Ras induces an immensely complicated network of signaling cascades that can lead to very different outcomes depending on cell type, genetic background, phenotype assayed for, and so forth. On top of all these differences, mounting evidence suggests that there may even be differences in Ras-mediated oncogenesis between rodents, the primary model system used to study Ras oncogenesis, and humans. In this chapter, we will summarize what Ras effector pathways have been implicated in the most common and stringent phenotypes of Ras transformed cells, anchorage-independent growth using soft agar assay and in vivo xenograft tumorigenesis using immunocompromised mice, between mice and human cells

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  1. Duke University Medical Center, Durham, NC

    Kian-Huat Lim & Christopher M. Counter

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  1. Kian-Huat Lim
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  1. University of North Carolina at Chapel Hill, U.S.A

    Channing Der

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Lim, KH., Counter, C.M. (2006). Comparison of the Effects of Ras Effector Mutants and Ras Effectors on Transformed and Tumorigenic Growth of Human and Rodent Cells. In: Der, C. (eds) RAS Family GTPases. Proteins and Cell Regulation, vol 4. Springer, Dordrecht. https://doi.org/10.1007/1-4020-4708-8_11

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