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Cell Motility in Cancer Invasion and Metastasis pp 221–243Cite as

Glioblastoma Cell Motility: The Role of FAK and Cellular SRC

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Part of the book series: Cancer Metastasis - Biology and Treatment ((CMBT,volume 8))

Abstract

Understanding the signaling events that promote glioblastoma tumor cell motility is crucial, as invasion of these tumors into the normal brain contributes significantly to the morbidity and mortality observed in patients with these tumors. Also, the molecular mechanisms that promote glioblastoma cell motility/migration likely also promote invasion. Here we discuss the role of two non-receptor tyrosine kinases, focal adhesion kinase (FAK) and cellular Src, in promoting glioblastoma cell motility/migration. We discuss the activation of FAK, the elevated levels of FAK protein found in these tumors, the domains in FAK that are necessary for it to promote cell motility/migration, and studies dissecting FAK function in glioblastoma tumors. We also discuss data indicating Src family members have specific functions and the role of Lyn in promoting glioblastoma cell migration. FAK and cellular Src could be important new targets for glioblastoma therapy.

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Authors and Affiliations

  1. Division of Neuropathology, Department of Pathology, The University of Alabama at Birmingham, Birmingham, AL, USA

    Michelle R. Stettner, Meera Natarajan & Candece L. Gladson

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  1. Michelle R. Stettner
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  2. Meera Natarajan
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  3. Candece L. Gladson
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  1. Department of Pathology, Pittsburgh VAMC, University of Pittsburgh, PA, USA

    Alan Wells

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Stettner, M.R., Natarajan, M., Gladson, C.L. (2006). Glioblastoma Cell Motility: The Role of FAK and Cellular SRC. In: Wells, A. (eds) Cell Motility in Cancer Invasion and Metastasis. Cancer Metastasis - Biology and Treatment, vol 8. Springer, Dordrecht. https://doi.org/10.1007/1-4020-4009-1_10

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