Abstract
Localized cancer, before it metastasizes, can be cured by surgery. The high mortality rate associated with most cancers, however, is due to the propensity of tumors to metastasize while the primary tumor is small and undetected. Metastasis, which occurs through a complex series of events, involves various gene products that dictate the progression of a cancer from a precursor lesion, to localized disease, and finally to metastatic disease. The expression of certain genes or alterations in gene structure or gene products may result in the progression of benign tumor cells to an invasive and metastatic state. Thus, the process of cancer metastasis requires, among other steps, changes in signaling pathways, activation of target gene products, enhanced cell survival, and increased epithelial-to-mesenchymal transition. A proper understanding of the progression of tumors to the metastatic stage and of the events that occur in highly malignant cells is important in the development of new therapeutic approaches for the diagnosis, treatment, and prognosis of highly progressive tumors. The molecular mechanisms that cause a cancer to exhibit more malignant behavior are widely believed to involve the deregulation of genetic and epigenetic cascades. We will here highlight the discovery and emerging significance of one family of regulators or chromatin modifiers, namely, the metastasis-associated antigens.
Key words
- Metastasis-associated protein 1 (MTA1)
- coactivators
- corepressors
- estrogen receptor
- metastasis
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Balasenthil, S., Kumar, R. (2005). Molecular Mechanisms of the Metastasis-Associated Gene Family of Coregulators: Role in Cancer and Invasion. In: Esteller, M. (eds) DNA Methylation, Epigenetics and Metastasis. Cancer Metastasis — Biology and Treatment, vol 7. Springer, Dordrecht. https://doi.org/10.1007/1-4020-3642-6_9
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DOI: https://doi.org/10.1007/1-4020-3642-6_9
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