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DNA Methylation, Epigenetics and Metastasis pp 231–242Cite as

The Molecular Mechanisms for Breast Cancer Metastasis Suppressor 1 Action in Cancer Metastasis

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Part of the Cancer Metastasis — Biology and Treatment book series (CMBT,volume 7)

Abstract

Recent advances in drug discoveries and understanding of epigenetic regulation of gene expression have brought histone deacetylases (HDACs) in spotlight. Breast Cancer Metastasis Suppressor 1 (BRMS1), a gene shown to functionally suppress metastasis of breast cancer and melanoma, is a member of mSin3-HDAC complex. This chapter reviews the emerging understanding of the molecular mechanisms of BRMS1 action and possible players involved in it. New evidence of BRMS1-family of proteins and their possible role in histone code is discussed.

Key words

  • BRMS1
  • HDAC
  • Sin3
  • histone code
  • metastasis suppressor

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Authors and Affiliations

  1. Cancer Research Institute, University of South Alabama, Mobile, AL, USA

    Rajeev S. Samant & Lalita A. Shevde

Authors
  1. Rajeev S. Samant
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  2. Lalita A. Shevde
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  1. Spanish National Cancer Centre (CNIO), Madrid, Spain

    Manel Esteller

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© 2005 Springer

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Samant, R.S., Shevde, L.A. (2005). The Molecular Mechanisms for Breast Cancer Metastasis Suppressor 1 Action in Cancer Metastasis. In: Esteller, M. (eds) DNA Methylation, Epigenetics and Metastasis. Cancer Metastasis — Biology and Treatment, vol 7. Springer, Dordrecht. https://doi.org/10.1007/1-4020-3642-6_10

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