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Photoprotection, Photoinhibition, Gene Regulation, and Environment pp 321–332Cite as

Lipoxygenases, Apoptosis, and the Role of Antioxidants

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Part of the Advances in Photosynthesis and Respiration book series (AIPH,volume 21)

Summary

Lipoxygenases are a family of enzymes that dioxygenate unsaturated fatty acids, thus initiating lipoperoxidation of membranes and the synthesis of signaling molecules, or inducing structural and metabolic changes in the cell. This activity is the basis for the critical role of lipoxygenases in a number of pathophysiological conditions, in both animals and plants. In the past few years, a pro-apoptotic effect of lipoxygenase has been reported in different cells and tissues, leading to cell death along unrelated apoptotic pathways. However, anti-apoptotic effects of lipoxygenases have also been reported, often based on the use of enzyme inhibitors. In the present review, the characteristics of the lipoxygenase family and the role of lipoxygenase activation in apoptosis of animal and plant cells are discussed, suggesting a common signal transduction pathway in cell death conserved through the evolution of both kingdoms. In addition, the inhibition of lipoxygenases by antioxidants and its consequences on apoptosis will be presented.

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Authors and Affiliations

  1. Department of Biomedical Sciences, University of Teramo, Piazza A. Moro 45, 64100 Teramo, Italy

    Mauro Maccarrone

  2. The IRCCS C. Mondino Mondino-Tor Vergata- Santa Lucia Center for Experimental Neurobiology, Via Ardeatina 306, 00179 Rome, Italy

    Mauro Maccarrone

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  1. Mauro Maccarrone
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  1. University of Colorado, Boulder, CO, U.S.A

    Barbara Demmig-Adams (Dr) & William W. Adams III (Dr) (Dr) &  (Dr)

  2. Henry A. Wallace Beltsville Agricultural Research Center, Beltsville, MD, U.S.A

    Autar K. Mattoo

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Maccarrone, M. (2008). Lipoxygenases, Apoptosis, and the Role of Antioxidants. In: Demmig-Adams, B., Adams, W.W., Mattoo, A.K. (eds) Photoprotection, Photoinhibition, Gene Regulation, and Environment. Advances in Photosynthesis and Respiration, vol 21. Springer, Dordrecht. https://doi.org/10.1007/1-4020-3579-9_20

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