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Regulation of Cell-Cell Adhesion by Rho Family GTPases

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RHO Family GTPases

Part of the book series: Proteins and Cell Regulation ((PROR,volume 3))

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Abstract

Cell-cell adhesion is a fundamental determinant of tissue organization. Adhesive interactions between cells help model body plan and histoarchitecture during development, while disorders of cell adhesion contribute to common diseases, including cancer and inflammation. Given their wide-ranging ramifications, it is not surprising that these interactions are subject to strict cellular regulation. In particular, classical cadherins, major mediators of cell-cell adhesion in many tissues, are key targets of Rho GTPase signalling. In this chapter we review recent developments in understanding the interrelationship between cadherin function and Rho family members. It is increasingly apparent that cadherin function is tightly regulated by membrane-local GTPase signals localized to cell-cell contacts. These may be activated both by cadherins themselves or by cadherin-dependent juxtacrine signalling receptors. These GTPases exert profound, but often pleiotropic effects on cadherin function, through their ability to regulate both cadherin-actin cooperativity and cadherin trafficking.

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Authors and Affiliations

  1. Division of Molecular Cell Biology, Institute for Molecular Bioscience, The University of Queensland, Queensland

    Astrid Kraemer & Alpha S. Yap

  2. School of Biomedical Science, The University of Queensland, Queensland

    Alpha S. Yap

Authors
  1. Astrid Kraemer
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  2. Alpha S. Yap
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Editor information

Editors and Affiliations

  1. Institute of Molecular and Cell Biology, Singapore

    Ed. Manser (Principle Investigator) (Principle Investigator)

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© 2005 Springer

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Kraemer, A., Yap, A.S. (2005). Regulation of Cell-Cell Adhesion by Rho Family GTPases. In: Manser, E. (eds) RHO Family GTPases. Proteins and Cell Regulation, vol 3. Springer, Dordrecht. https://doi.org/10.1007/1-4020-3462-8_8

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