Skip to main content
SpringerLink
Log in

Dynamics of Cell Adhesion Interactions during Melanoma Development

  • Chapter
Integration/Interaction of Oncologic Growth

Part of the book series: Cancer Growth and Progression ((CAGP,volume 15))

Abstract

Cell adhesion interactions are important processes during normal development and malignant transformation. Recent studies have shown that in melanoma, cell adhesion interactions play a critical role in regulating melanocytic cell proliferation, differentiation, migration, apoptosis and even vasculature mimicry. In the review we will discuss recent progresses in the study of the dynamic expression and function of the adhesion molecules in melanoma development.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Ries, L.A., et al., 2000, The annual report to the nation on the status of cancer, 1973–1997, with a special section on colorectal cancer. Cancer, 88:2398–2424.

    Article  PubMed  Google Scholar 

  2. Christofori, G. and Semb, H., 1999, The role of the cell-adhesion molecule E-cadherin as a tumour-suppressor gene. Trends Biochem Sci, 24:73–76.

    Article  PubMed  Google Scholar 

  3. Li, G., and Herlyn, M., 2000, Dynamics of intercellular communication during melanoma development. Mol Med Today, 6:163–169.

    Article  PubMed  Google Scholar 

  4. Clark, W.H., Jr. et al., 1984, A study of tumor progression: the precursor lesions of superficial spreading and nodular melanoma:Lack of association between intraocular melanoma and cutaneous dysplastic nevi. Human Pathology, 15:1147–1165.

    PubMed  Google Scholar 

  5. Meier, F. et al., 1998, Molecular events in melanoma development and progression. Front Biosci, 3:D1005–1010.

    PubMed  Google Scholar 

  6. Hsu, M.Y. et al., 2000, E-cadherin expression in melanoma cells restores keratinocyte-mediated growth control and down-regulates expression of invasion-related adhesion receptors. Am J Pathol, 156:1515–1525.

    PubMed  Google Scholar 

  7. Li, G., Satyamoorthy, K., and Herlyn, M., 2002, Dynamics of cell interactions and communication during melanoma development. Crit Rev Oral Biol Med, 13:62–70.

    PubMed  Google Scholar 

  8. Hsu, M.Y. et al., 1998, Adenoviral gene transfer of beta3 integrin subunit induces conversion from radial to vertical growth phase in primary human melanoma. Am J Pathol, 153:1435–1442.

    PubMed  Google Scholar 

  9. Bissell, M.J. and Radisky, D., 2001, Putting tumours in context. Nature Reviews, 1:46–54.

    Article  PubMed  Google Scholar 

  10. Gumbiner, B.M., 2000, Regulation of cadherin adhesive activity. J Cell Biol, 148:399–404.

    Article  PubMed  Google Scholar 

  11. Kowalczyk, A.P., Bornslaeger, E.A., Norvell, S.M., Palka, H.L., and Green, K.J., 1999, Desmosomes: intercellular adhesive junctions specialized for attachment of intermediate filaments. Int Rev Cytol, 185:237–302.

    PubMed  Google Scholar 

  12. Goodenough, D.A., Goliger, J.A., and Paul, D.L., 1996, Connexins, connexons, and intercellular communication. Annu Rev Biochem, 65:475–502.

    Article  PubMed  Google Scholar 

  13. Stevenson, B.R., and Keon, B.H., 1998, The tight junction: morphology to molecules. Annu Rev Cell Dev Biol, 14:89–109.

    Article  PubMed  Google Scholar 

  14. Morita, K., Furuse, M., Fujimoto, K., and Tsukita, S., 1999, Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands. Proc Natl Acad Sci U S A, 96:511–516, 1999,.

    Article  Google Scholar 

  15. Lehmann, J.M., Riethmuller, G., and Johnson, J.P., 1989, MUC18, a marker of tumor progression in human melanoma, shows sequence similarity to the neural cell adhesion molecules of the immunoglobulin superfamily. Proc Natl Acad Sci U S A, 86:9891–9895.

    PubMed  Google Scholar 

  16. Johnson, J.P., 1991, The role of ICAM-1 in tumor development. Chem Immunol, 50:143–163.

    PubMed  Google Scholar 

  17. Hynes, R.O., 1992, Integrins: versatility, modulation, and signaling in cell adhesion. Cell, 69:11–25.

    Article  PubMed  Google Scholar 

  18. Johnson, J.P., Cell adhesion molecules in the development and progression of malignant melanoma. Cancer Metastasis Rev, 18:345–357.

    Google Scholar 

  19. Siliciano, J.D., and Goodenough, D.A., 1988, Localization of the tight junction protein, ZO-1, is modulated by extracellular calcium and cell-cell contact in Madin-Darby canine kidney epithelial cells. J Cell Biol, 107:2389–2399.

    Article  Google Scholar 

  20. Pasdar, M., and Nelson, W.J., 1988, Kinetics of desmosome assembly in Madin-Darby canine kidney epithelial cells: temporal and spatial regulation of desmoplakin organization and stabilization upon cell-cell contact. I. Biochemical analysis. J Cell Biol, 106:677–685.

    Article  PubMed  Google Scholar 

  21. Frenzel, E.M. and Johnson, R.G. Gap junction formation between cultured embryonic lens cells is inhibited by antibody to N-cadherin. Dev Biol 179 1–16, 1996,.

    Article  PubMed  Google Scholar 

  22. Fujimoto, K., et al., 1997, Dynamics of connexins, E-cadherin and alpha-catenin on cell membranes during gap junction formation. J Cell Sci, 110:311–322.

    PubMed  Google Scholar 

  23. Li, G., et al., 2003, Function and regulation of melanoma-stromal fibroblast interactions: when seeds meet soil Downregulation of E-cadherin and Desmoglein 1 by autocrine hepatocyte growth factor during melanoma development. Oncogene, 22:3162–3171.

    Article  PubMed  Google Scholar 

  24. Tang, A., et al., 1994, E-cadherin is the major mediator of human melanocyte adhesion to keratinocytes in vitro. J Cell Sci, 107:983–992.

    PubMed  Google Scholar 

  25. Furukawa, F., et al., 1997, Roles of E-and P-cadherin in the human skin. Microsc Res Tech, 38:343–352.

    Article  PubMed  Google Scholar 

  26. Hsu, M.Y., Wheelock, M.J., Johnson, K.R., and Herlyn, M., 1996, Shifts in cadherin profiles between human normal melanocytes and melanomas. J Investig Dermatol Symp Proc, 1:188–194.

    PubMed  Google Scholar 

  27. Gumbiner, B.M., 1996, Cell adhesion: the molecular basis of tissue architecture and morphogenesis. Cell, 84:345–357.

    Article  Google Scholar 

  28. Kikuchi, A., 2000, Regulation of beta-catenin signaling in the Wnt pathway. Biochemical and Biophysical Research Communications, 268:243–248.

    Article  PubMed  Google Scholar 

  29. Takeichi, M., 1995, Morphogenetic roles of classic cadherins. Curr Opin Cell Biol, 7:619–627.

    Article  PubMed  Google Scholar 

  30. Nishimura, E.K., Yoshida, H., Kunisada, T., and Nishikawa, S.I., 1999, Regulation of E-and P-cadherin expression correlated with melanocyte migration and diversification. Dev Biol, 215:155–166.

    Article  PubMed  Google Scholar 

  31. Hirai, Y., Nose, A., Kobayashi, S., and Takeichi, M., 1989, Expression and role of E-and P-cadherin adhesion molecules in embryonic histogenesis. II. Skin morphogenesis. Development, 105:271–277.

    PubMed  Google Scholar 

  32. Takeichi, M., 1988, The cadherins: cell-cell adhesion molecules controlling animal morphogenesis. Development, 102:639–655.

    PubMed  Google Scholar 

  33. Garrod, D.R., 1993, Desmosomes and hemidesmosomes. Curr Opin Cell Biol, 5:30–40.

    Article  PubMed  Google Scholar 

  34. Koch, P.J., and Franke, W.W., 1994, Desmosomal cadherins: another growing multigene family of adhesion molecules. Curr Opin Cell Biol, 6:682–687.

    Article  PubMed  Google Scholar 

  35. North, A.J., et al., 1999, Molecular map of the desmosomal plaque. J Cell Sci, 112:4325–4336.

    PubMed  Google Scholar 

  36. Bornslaeger, E.A., Corcoran, C.M., Stappenbeck, T.S., and Green, K.J., 1996, Breaking the connection: displacement of the desmosomal plaque protein desmoplakin from cell-cell interfaces disrupts anchorage of intermediate filament bundles and alters intercellular junction assembly. J Cell Biol, 134:985–1001.

    Article  PubMed  Google Scholar 

  37. Kouklis, P.D., Hutton, E., and Fuchs, E., 1994, Making a connection: direct binding between keratin intermediate filaments and desmosomal proteins. J Cell Biol, 127:1049–1060.

    Article  PubMed  Google Scholar 

  38. Smith, E.A. and Fuchs, E., 1998, Defining the interactions between intermediate filaments and desmosomes. J Cell Biol, 141:1229–1241.

    Article  PubMed  Google Scholar 

  39. Aberle, H. et al., 1994, Assembly of the cadherincatenin complex in vitro with recombinant proteins. J Cell Sci, 107:3655–3663.

    PubMed  Google Scholar 

  40. Butz, S., and Kemler, R., 1994, Distinct cadherincatenin complexes in Ca,2+,-dependent cell-cell adhesion. FEBS Lett, 355:195–200.

    Article  PubMed  Google Scholar 

  41. Lewis, J.E. et al., 1997, Cross-talk between adherens junctions and desmosomes depends on plakoglobin. J Cell Biol, 136:919–934.

    Article  PubMed  Google Scholar 

  42. Conn, I.G., Vilela, M.J., Garrod, D.R., Crocker, J., and Wallace, D.M., 1990, Immunohistochemical staining with monoclonal antibody 32-2B to desmosomal glycoprotein 1. Its role in the histological assessment of urothelial carcinomas. Br J Urol, 65:176–180.

    PubMed  Google Scholar 

  43. Depondt, J., Shabana, A.H., Florescu-Zorila, S., Gehanno, P., and Forest, N. 1999, Down-regulation of desmosomal molecules in oral and pharyngeal squamous cell carcinomas as a marker for tumour growth and distant metastasis. Eur J Oral Sci, 107:183–193.

    Article  PubMed  Google Scholar 

  44. Krunic, A.L., Garrod, D.R., Smith, N.P., Orchard, G.S., and Cvijetic, O.B., 1996, Differential expression of desmosomal glycoproteins in keratoacanthoma and squamous cell carcinoma of the skin: an immunohistochemical aid to diagnosis. Acta Derm Venereol, 76:394–398.

    PubMed  Google Scholar 

  45. Shinohara, M., et al., 1998, Immunohistochemical study of desmosomes in oral squamous cell carcinoma: correlation with cytokeratin and E-cadherin staining, and with tumour behaviour. J Pathol, 184:369–381.

    Article  PubMed  Google Scholar 

  46. De Bruin, A., et al., 1999, Loss of invasiveness in squamous cell carcinoma cells overexpressing desmosomal cadherins. Cell Adhes Commun, 7:13–28.

    PubMed  Google Scholar 

  47. Tada, H., Hatoko, M., Tanaka, A., Kuwahara, M., and Muramatsu, T., 2000, Expression of desmoglein I and plakoglobin in skin carcinomas. J Cutan Pathol, 27:24–29.

    Article  PubMed  Google Scholar 

  48. Silye, R., et al., 1998, E-cadherin/catenin complex in benign and malignant melanocytic lesions. J Pathol, 186:350–355.

    Article  Google Scholar 

  49. Danen, E.H. et al., 1996, E-cadherin expression in human melanoma. Melanoma Res, 6:127–131.

    PubMed  Google Scholar 

  50. Scott, G.A., and Cassidy, L., 1998, Rac1 mediates dendrite formation in response to melanocyte stimulating hormone and ultraviolet light in a murine melanoma model. J Invest Dermatol, 111:243–250.

    Article  PubMed  Google Scholar 

  51. Hirohashi, S., 1998, Inactivation of the E-cadherin-mediated cell adhesion system in human cancers. Am J Pathol, 153:333–339.

    PubMed  Google Scholar 

  52. Guilford, P., 1999, E-cadherin downregulation in cancer: fuel on the fire?. Mol Med Today, 5:172–177.

    Article  Google Scholar 

  53. Graff, J.R., et al., 1995, E-cadherin expression is silenced by DNA hypermethylation in human breast and prostate carcinomas. Cancer Res, 55:5195–5199.

    PubMed  Google Scholar 

  54. Graff, J.R., Gabrielson, E., Fujii, H., Baylin, S.B., and Herman, J.G., 2000, Methylation patterns of the E-cadherin 5′ CpG island are unstable and reflect the dynamic, heterogeneous loss of E-cadherin expression during metastatic progression. J Biol Chem, 275:2727–2732.

    Article  PubMed  Google Scholar 

  55. Yoshiura, K., et al., 1995, Silencing of the E-cadherin invasion-suppressor gene by CpG methylation in human carcinomas. Proc Natl Acad Sci U S A, 92:7416–7419.

    PubMed  Google Scholar 

  56. Cano, A., et al., 2000, The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression. Nat Cell Biol, 2:76–83.

    Article  PubMed  Google Scholar 

  57. Nieto, M.A., Sargent, M.G., Wilkinson, D.G., and Cooke, J., 1994, Control of cell behavior during vertebrate development by Slug, a zinc finger gene. Science, 264:835–839.

    PubMed  Google Scholar 

  58. Batlle, E., et al., 2000, The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells. Nat Cell Biol, 2:84–89.

    Article  PubMed  Google Scholar 

  59. Yokoyama, K., et al., 2001, Reverse correlation of E-cadherin and snail expression in oral squamous cell carcinoma cells in vitro. Oral Oncol, 37:65–71.

    Article  PubMed  Google Scholar 

  60. Lochter, A., et al., 1997, Matrix metalloproteinase stromelysin-1 triggers a cascade of molecular alterations that leads to stable epithelial-to-mesenchymal conversion and a premalignant phenotype in mammary epithelial cells. J Cell Biol, 139:1861–1872.

    Article  PubMed  Google Scholar 

  61. Li, G., Satyamoorthy, K., and Herlyn, M., 2001, N-cadherin-mediated intercellular interactions promote survival and migration of melanoma cells. Cancer Res, 61:3819–3825.

    PubMed  Google Scholar 

  62. Poser, I., et al., 2001, Loss of E-cadherin expression in melanoma cells involves upregulation of the transcriptional repressor Snail. J Biol Chem, 25:25.

    Google Scholar 

  63. Li, G., et al., 2001, Downregulation of E-cadherin and Desmoglein 1 by autocrine hepatocyte growth factor during melanoma development. Oncogene, 20:8125–8135.

    Article  PubMed  Google Scholar 

  64. Nakamura, T., et al., 1989, Molecular cloning and expression of human hepatocyte growth factor. Nature, 342:440–443.

    Article  PubMed  Google Scholar 

  65. Sonnenberg, E., Meyer, D., Weidner, K.M., and Birchmeier, C., 1993, Scatter factor/hepatocyte growth factor and its receptor, the c-met tyrosine kinase, can mediate a signal exchange between mesenchyme and epithelia during mouse development. J Cell Biol, 123:223–235.

    Article  PubMed  Google Scholar 

  66. Bottaro, D.P., et al., 1991, Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product. Science, 251:802–804.

    PubMed  Google Scholar 

  67. Rosen, E.M., Nigam, S.K., and Goldberg, I.D., 1994, Scatter factor and the c-met receptor: a paradigm for mesenchymal/epithelial interaction. J Cell Biol, 127:1783–1787.

    Article  Google Scholar 

  68. Bellusci, S., et al., 1994, Creation of an hepatocyte growth factor/scatter factor autocrine loop in carcinoma cells induces invasive properties associated with increased tumorigenicity. Oncogene, 9: 1091–1099.

    PubMed  Google Scholar 

  69. Tamatani, T., Hattori, K., Iyer, A., Tamatani, K., and Oyasu, R., 1999, Hepatocyte growth factor is an invasion/migration factor of rat urothelial carcinoma cells in vitro. Carcinogenesis, 20:957–962.

    Article  Google Scholar 

  70. To, C.T., and Tsao, M.S., 1998, The roles of hepatocyte growth factor/scatter factor and met receptor in human cancers, Review, Oncol Rep, 5:1013–1024.

    Google Scholar 

  71. Vande Woude, G.F., et al., 1997, Met-HGF/SF: tumorigenesis, invasion and metastasis. Ciba Found Symp, 212:119–130.

    PubMed  Google Scholar 

  72. Moriyama, T., Kataoka, H., Koono, M., and Wakisaka, S., 1999, Expression of hepatocyte growth factor/scatter factor and its receptor c-Met in brain tumors: evidence for a role in progression of astrocytic tumors, Review, Int J Mol Med, 3:531–536.

    Google Scholar 

  73. DeLuca, S.M., et al., 1999, Hepatocyte growth factor/scatter factor promotes a switch from E-to N-cadherin in chick embryo epiblast cells. Exp Cell Res, 251: 3–15.

    Article  Google Scholar 

  74. Trusolino, L., et al., 1998, Growth factor-dependent activation of alphavbeta3 integrin in normal epithelial cells: implications for tumor invasion. J Cell Biol, 142:1145–1156.

    Article  PubMed  Google Scholar 

  75. Albelda, S.M., et al., 1990, Integrin distribution in malignant melanoma: association of the beta 3 subunit with tumor progression. Cancer Res, 50:6757–6764.

    PubMed  Google Scholar 

  76. Van Belle, P.A., et al., 1999, Progression-related expression of beta3 integrin in melanomas and nevi. Hum Pathol, 30:562–567.

    Article  Google Scholar 

  77. Sefton, M., Sanchez, S., and Nieto, M.A., 1998, Conserved and divergent roles for members of the Snail family of transcription factors in the chick and mouse embryo. Development, 125:3111–3121.

    PubMed  Google Scholar 

  78. Hajra, K.M., Chen, D.Y., and Fearon, E.R., 2002, The SLUG Zinc-Finger Protein Represses E-Cadherin in Breast Cancer. Cancer Res, 62:1613–1618.

    PubMed  Google Scholar 

  79. Savagner, P., Yamada, K.M., and Thiery, J.P., 1997, The zinc-finger protein slug causes desmosome dissociation, an initial and necessary step for growth factor-induced epithelial-mesenchymal transition. J Cell Biol, 137:1403–1419.

    Article  PubMed  Google Scholar 

  80. Hatta, K., and Takeichi, M., 1986, Expression of N-cadherin adhesion molecules associated with early morphogenetic events in chick development. Nature, 320:447–449.

    Article  PubMed  Google Scholar 

  81. Edelman, G.M., Gallin, W.J., Delouvee, A., Cunningham, B.A., and Thiery, J.P., 1983, Early epochal maps of two different cell adhesion molecules. Proc Natl Acad Sci U S A, 80:4384–4388.

    PubMed  Google Scholar 

  82. Jouneau, A., Yu, Y.Q., Pasdar, M., and Larue, L., 2000, Plasticity of cadherin-catenin expression in the melanocyte lineage. Pigment Cell Res, 13:260–272.

    Article  PubMed  Google Scholar 

  83. Tran, N.L., Nagle, R.B., Cress, A.E., and Heimark, R.L., 1999, N-Cadherin expression in human prostate carcinoma cell lines. An epithelial-mesenchymal transformation mediating adhesion withStromal cells. Am J Pathol, 155:787–798.

    PubMed  Google Scholar 

  84. Husmark, J., Heldin, N.E., and Nilsson, M. 1999, N-cadherin-mediated adhesion and aberrant catenin expression in anaplastic thyroid-carcinoma cell lines. Int J Cancer, 83:692–699.

    Article  Google Scholar 

  85. Kawamura-Kodama, K., Tsutsui, J., Suzuki, S.T., Kanzaki, T., and Ozawa, M., N-cadherin expressed on malignant T cell lymphoma cells is functional, and promotes heterotypic adhesion between the lymphoma cells and mesenchymal cells expressing N-cadherin. J Invest Dermatol 112, 62–66, 1999,.

    Article  PubMed  Google Scholar 

  86. Hsu, M., Andl, T., Li, G., Meinkoth, J.L. and Herlyn, M., 2000, Cadherin repertoire determines partner-specific gap junctional communication during melanoma progression. J Cell Sci, 113:1535–1542.

    PubMed  Google Scholar 

  87. Navarro, P., Ruco, L., and Dejana, E., 1998, Differential localization of VE-and N-cadherins in human endothelial cells: VE-cadherin competes with N-cadherin for junctional localization. J Cell Biol, 140:1475–1484.

    Article  PubMed  Google Scholar 

  88. Jahroudi, N., and Greenberger, J.S., 1995, The role of endothelial cells in tumor invasion and metastasis. J Neurooncol, 23:99–108.

    Article  PubMed  Google Scholar 

  89. Sandig, M., Voura, E.B., Kalnins, V.I., and Siu, C.H., 1997, Role of cadherins in the transendothelial migration of melanoma cells in culture. Cell Motil Cytoskeleton, 38:351–364.

    Article  PubMed  Google Scholar 

  90. Voura, E.B., Sandig, M., and Siu, C.H., 1998, Cell-cell interactions during transendothelial migration of tumor cells. Microsc Res Tech, 43:265–275.

    Article  PubMed  Google Scholar 

  91. Ruoslahti, E., and Obrink, B., 1996, Common principles in cell adhesion. Exp Cell Res, 227:1–11.

    Article  Google Scholar 

  92. Bixby, J.L., and Zhang, R., 1990, Purified N-cadherin is a potent substrate for the rapid induction of neurite outgrowth. J Cell Biol, 110:1253–1260.

    Article  PubMed  Google Scholar 

  93. Doherty, P., and Walsh, F.S., 1991, The contrasting roles of N-CAM and N-cadherin as neurite outgrowth-promoting molecules. J Cell Sci Suppl, 15:13–21.

    PubMed  Google Scholar 

  94. Riehl, R., et al., 1996, Cadherin function is required for axon outgrowth in retinal ganglion cells in vivo. Neuron, 17:837–848.

    Article  PubMed  Google Scholar 

  95. Hazan, R.B., Kang, L., Whooley, B.P., and Borgen, P.I., 1997, N-cadherin promotes adhesion between invasive breast cancer cells and the stroma. Cell Adhes Commun, 4:399–411.

    PubMed  Google Scholar 

  96. Hazan, R.B., Phillips, G.R., Qiao, R.F., Norton, L., and Aaronson, S.A., 2000, Exogenous expression of N-cadherin in breast cancer cells induces cell migration, invasion, and metastasis [published erratum appears in J Cell Biol, Apr 3:149,1, following 236]. J Cell Biol, 148:779–790.

    Article  PubMed  Google Scholar 

  97. Nabeshima, K., Inoue, T., Shimao, Y., Kataoka, H., and Koono, M., 1999, Cohort migration of carcinoma cells: differentiated colorectal carcinoma cells move as coherent cell clusters or sheets. Histol Histopathol, 14:1183–1197.

    PubMed  Google Scholar 

  98. Nieman, M.T., Prudoff, R.S., Johnson, K.R., and Wheelock, M.J., 1999, N-cadherin promotes motility in human breast cancer cells regardless of their E-cadherin expression. J Cell Biol, 147:631–644.

    Article  PubMed  Google Scholar 

  99. Williams, E.J., Furness, J., Walsh, F.S., and Doherty, P., 1994, Activation of the FGF receptor underlies neurite outgrowth stimulated by L1, NCAM, and N-cadherin. Neuron, 13:583–594.

    Article  PubMed  Google Scholar 

  100. Evans, W.H., 1994, Assembly of gap junction intercellular communication channels. Biochem Soc Trans, 22:788–792.

    PubMed  Google Scholar 

  101. Kuraoka, A., Inai, T., Ishibashi, T., and Shibata, Y., 2001, Diversity and molecular anatomy of gap junctions. Histochemistry and Cell Biology, 115:277–284.

    PubMed  Google Scholar 

  102. Ito, A., et al., 2000, A role for heterologous gap junctions between melanoma and endothelial cells in metastasis. J Clin Invest, 105:1189–1197.

    PubMed  Google Scholar 

  103. Satyamoorthy, K., Muyrers, J., Meier, F., Patel, D., and Herlyn, M., 2001, Mel-CAM-specific genetic suppressor elements inhibit melanoma growth and invasion through loss of gap junctional communication. Oncogene, 20:4676–4684.

    Article  PubMed  Google Scholar 

  104. Huang, R.P., et al., 1998, Reversion of the neoplastic phenotype of human glioblastoma cells by connexin 43, cx43. Cancer Res, 58:5089–5096.

    PubMed  Google Scholar 

  105. Armstrong, D.K., et al., 1999, Haploinsufficiency of desmoplakin causes a striate subtype of palmoplantar keratoderma. Hum Mol Genet, 8:143–148.

    Article  Google Scholar 

  106. Johnson, J.P., 1992, Cell adhesion molecules in neoplastic disease. Int J Clin Lab Res, 22:69–72.

    PubMed  Google Scholar 

  107. Sers, C., Kirsch, K., Rothbacher, U., Riethmuller, G., and Johnson, J.P., 1993, Genomic organization of the melanoma-associated glycoprotein MUC18: implications for the evolution of the immunoglobulin domains. Proc Natl Acad Sci U S A, 90:8514–8518.

    PubMed  Google Scholar 

  108. Lehmann, J.M., et al., 1987, Discrimination between benign and malignant cells of melanocytic lineage by two novel antigens, a glycoprotein with a molecular weight of 113,000 and a protein with a molecular weight of 76,000. Cancer Res, 47:841–845.

    PubMed  Google Scholar 

  109. Shih, I.M., Speicher, D., Hsu, M.Y., Levine, E., and Herlyn, M., 1997, Melanoma cell-cell interactions are mediated through heterophilic Mel-CAM/ligand adhesion. Cancer Res, 57:3835–3840.

    PubMed  Google Scholar 

  110. Shih, I.M., Elder, D.E., Speicher, D., Johnson, J.P., and Herlyn, M., 1994, Isolation and functional characterization of the A32 melanoma-associated antigen. Cancer Res, 54:2514–2520.

    PubMed  Google Scholar 

  111. Luca, M., et al., 1993, Direct correlation between MUC18 expression and metastatic potential of human melanoma cells. Melanoma Res, 3:35–41.

    PubMed  Google Scholar 

  112. Xie, S., et al., 1997, Expression of MCAM/MUC18 by human melanoma cells leads to increased tumor growth and metastasis. Cancer Res, 57:2295–2303.

    PubMed  Google Scholar 

  113. Johnson, J.P., Bar-Eli, M., Jansen, B., and Markhof, E., 1997, Melanoma progression-associated glycoprotein MUC18/MCAM mediates homotypic cell adhesion through interaction with a heterophilic ligand. Int J Cancer, 73:769–774.

    Article  PubMed  Google Scholar 

  114. Anfosso, F., et al., 1998, Activation of human endothelial cells via S-endo-1 antigen, CD146, stimulates the tyrosine phosphorylation of focal adhesion kinase p125,FAK. J Biol Chem, 273:26852–26856.

    Article  PubMed  Google Scholar 

  115. Datta, S.R., et al., 1997, Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell, 91:231–241.

    Article  PubMed  Google Scholar 

  116. Satyamoorthy, K., et al., 2003, Constitutive mitogen-activated protein kinase activation in melanoma is mediated by both BRAF mutations and autocrine growth factor stimulation. Cancer Research, 63:756–759.

    PubMed  Google Scholar 

  117. Singh, A.B., Ellis, D.L., Richmond, A., and Dhawan, P., 2002, Constitutive activation of Akt/protein kinase B in melanoma leads to up-regulation of nuclear factor-kappaB and tumor progression. Cancer Research, 62:7335–7342.

    PubMed  Google Scholar 

  118. Sirim, P., et al., 1999, Pathological missense mutations of neural cell adhesion molecule L1 affect homophilic and heterophilic binding activities. Journal of Cell Biology, 145:865–876.

    Article  PubMed  Google Scholar 

  119. MacFarlane, J., et al., 1999, The L1 family of neural cell adhesion molecules: old proteins performing new tricks. EMBO Journal, 18:4744–4753.

    Article  PubMed  Google Scholar 

  120. Linnemann, D., Raz, A., and Bock, E., 1989, Differential expression of cell adhesion molecules in variants of K1735 melanoma cells differing in metastatic capacity. Int J Cancer, 43:709–712.

    PubMed  Google Scholar 

  121. Fogel, M., et al., 2003, L1 adhesion molecule, CD 171, in development and progression of human malignant melanoma. Cancer Letters, 189:237–247.

    Article  Google Scholar 

  122. Thies, A., et al., 2002, Overexpression of the cell adhesion molecule L1 is associated with metastasis in cutaneous malignant melanoma. European Journal of Cancer, 38:1708–1716.

    Article  PubMed  Google Scholar 

  123. Schuch, U., Lohse, M.J., and Schachner, M., 1989, Neural cell adhesion molecules influence second messenger systems. Neuron, 3:13–20.

    Article  PubMed  Google Scholar 

  124. Davis, J.Q., and Bennett, V., 1994, Ankyrin binding activity shared by the neurofascin/L1/NrCAM family of nervous system cell adhesion molecules. J Biol Chem, 269:27163–27166.

    PubMed  Google Scholar 

  125. Wong, E.V., Schaefer, A.W., Landreth, G., and Lemmon, V., 1996, Involvement of p90rsk in neurite outgrowth mediated by the cell adhesion molecule L1. J Biol Chem, 271:18217–18223.

    Article  PubMed  Google Scholar 

  126. Dahlin-Huppe, K., Berglund, E.O., Ranscht, B., and Stallcup, W.B., 1997, Mutational analysis of the L1 neuronal cell adhesion molecule identifies membrane-proximal amino acids of the cytoplasmic domain that are required for cytoskeletal anchorage. Mol Cell Neurosci, 9:144–156.

    Article  PubMed  Google Scholar 

  127. Ohnishi, T., Matsumura, H., Izumoto, S., Hiraga, S., and Hayakawa, T., 1998, A novel model of glioma cell invasion using organotypic brain slice culture. Cancer Res, 58:2935–2940.

    PubMed  Google Scholar 

  128. Schadendorf, D., et al., 1993, IL-8 produced by human malignant melanoma cells in vitro is an essential autocrine growth factor. J Immunol, 151:2667–2675.

    PubMed  Google Scholar 

  129. Schadendorf, D., Heidel, J., Gawlik, C., Suter, L., and Czarnetzki, B.M., 1995, Association with clinical outcome of expression of VLA-4 in primary cutaneous malignant melanoma as well as P-selectin and E-selectin on intratumoral vessels. Journal of the National Cancer Institute, 87:366–371.

    PubMed  Google Scholar 

  130. Natali, P.G., et al., 1993, Expression of the c-Met/HGF receptor in human melanocytic neoplasms: demonstration of the relationship to malignant melanoma tumour progression. Br J Cancer, 68:746–750.

    PubMed  Google Scholar 

  131. van der Flier, A., Sonnenberg, A., and Favre, B., 2001, Function and interactions of integrins. The hemidesmosomal protein bullous pemphigoid antigen 1 and the integrin beta 4 subunit bind to ERBIN. Molecular cloning of multiple alternative splice variants of ERBIN and analysis of their tissue expression. Cell and Tissue Research, 305:285–298.

    Article  PubMed  Google Scholar 

  132. Eliceiri, B.P., and Cheresh, D.A., 2001, Adhesion events in angiogenesis. Circulation Research, 89:1104–1110.

    PubMed  Google Scholar 

  133. Hynes, R.O., 2002, Integrins: bidirectional, allosteric signaling machines. A reevaluation of integrins as regulators of angiogenesis. Cell, 110:673–687.

    PubMed  Google Scholar 

  134. Sudhakar, A., et al., 2002, New aspects of integrin signaling in cancer. Science, 295:140–143.

    Article  Google Scholar 

  135. Liotta, L.A., and Kohn, E.C., 2001, The microenvironment of the tumour-host interface. Nature, 411:375–379.

    Article  PubMed  Google Scholar 

  136. Hutter, C., et al., 2002, Integrins in invasive growth. Development, 129:2303–2315.

    PubMed  Google Scholar 

  137. Cheresh, D.A., and Eliceiri, B.P., 2002, Src-mediated coupling of focal adhesion kinase to integrin alpha,v,beta5 in vascular endothelial growth factor signaling. Journal of Cell Science, 115:3729–3738.

    Article  PubMed  Google Scholar 

  138. Sherman, L., et al., 1999, Molecular role,s, for integrins in human melanoma invasion. Human Molecular Genetics, 8:267–275.

    Article  PubMed  Google Scholar 

  139. Montgomery, A.M., et al., 1994, Integrin alpha v beta 3 rescues melanoma cells from apoptosis in three-dimensional dermal collagen. Cell, 79:1157–1164.

    Article  PubMed  Google Scholar 

  140. Okahara, H., Yagita, H., Miyake, K., and Okumura, K., 1994, Involvement of very late activation antigen 4, VLA-4, and vascular cell adhesion molecule 1, VCAM-1, in tumor necrosis factor alpha enhancement of experimental metastasis. Cancer Research, 54:3233–3236.

    PubMed  Google Scholar 

  141. Al-Mehdi, A.B., et al., 1998, Intravascular origin of metastasis from the proliferation of endothelium-attached tumor cells: a new model for metastasis. Nature Medicine, 6:100–102, 2000.

    Google Scholar 

  142. Seftor, E.A., et al., 2000, Vasculogenic mimicry and tumor angiogenesis. Laboratory Investigation 78, 153–163,.

    Google Scholar 

  143. Hendrix, M.J. and Maniotis, A.J. Vascular channel formation by human melanoma cells in vivo and in vitro: vasculogenic mimicry. [see comment]. American Journal of Pathology, 156:361–381.

    Google Scholar 

  144. Sood, A., et al., 2001, The clinical significance of tumor cell-lined vasculature in ovarian carcinoma: implications for anti-vasculogenic therapy. Indian Journal of Gastroenterology, 20:22–23.

    PubMed  Google Scholar 

  145. Eliceiri, B.P., and Cheresh, D.A., 2000, Role of alpha v integrins during angiogenesis. Cancer Journal, 6:Suppl 3:S245–249.

    Google Scholar 

  146. Masuda, H., Kalka, C., and Asahara, T., 2000, Endothelial progenitor cells for regeneration. Human Cell, 13: 153–160.

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. The Wistar Institute, 3601 Spruce Street, Philadelphia, PA, 19104, USA

    G. Li & M. Herlyn

Authors
  1. G. Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Herlyn
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Washington State University, Pullman, WA, USA

    Gary G. Meadows

Rights and permissions

Reprints and permissions

Copyright information

© 2005 Springer

About this chapter

Cite this chapter

Li, G., Herlyn, M. (2005). Dynamics of Cell Adhesion Interactions during Melanoma Development. In: Meadows, G.G. (eds) Integration/Interaction of Oncologic Growth. Cancer Growth and Progression, vol 15. Springer, Dordrecht. https://doi.org/10.1007/1-4020-3414-8_5

Download citation

Publish with us

Policies and ethics

Search

Navigation