Abstract
The first complete genome sequence of an organism was for yeast, in 1996. Since then, the much larger task of doing a complete human sequence has been completed. Those of major domestic animals are following rapidly. It will always be impossible to foresee the full potential of such an explosion in knowledge, but aspects of gene-based technologies are already beginning to have an impact in the livestock sector.
The first and most obvious area of impact concerns feed supply, which constitutes 50–75 percent of total costs in many livestock systems. Production costs for maize and soybean are being reduced by genetic modification of the crop for herbicide and insect resistance. Maize has been modified to reduce phosphorous and nitrogen excretion in swine and poultry, and also to provide a more valuable amino acid balance.
Genetic modification of the animal is also possible. Most dramatically, the insertion of a growth hormone in the DNA of fish accelerates growth. However, in this and all other cases, the genetic modification (GM) of animals has produced profound physiological disturbances. At the same time, the administration of GM-produced growth hormone to dairy cows is now routine in the United States of America and several other countries. This is not permitted in Europe, where the attitude to all GM technologies has been much more cautious.
Conventional selection programmes continue to deliver steady genetic improvement in all animal populations. New molecular methods offer the prospect of enhancing genetic gains, particularly for traits that are difficult or expensive to measure, or which have low heritability.
Gene technologies have much to contribute to the control of disease in animals. As pressure to reduce antibiotic and drug use increases, genetically modified vaccines with proven specificity and distinguishable from natural infections are already in use. DNA typing is helping with rapid and precise diagnosis. In addition, the interaction of some pathogens (e.g. scrapie) with the genotype of the animal calls for the application of DNA technologies.
Following the BSE epidemic in Europe, safety of livestock-derived foods is high on research and regulatory agendas. DNA techniques are already in use for tracking of sources of Salmonella enterica and Escherichia coli outbreaks, as well as for traceability of product in the food chain.
Finally, gene-based technologies can facilitate the measurement and conservation of genetic diversity in animal populations.
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References
Bradley, D.G., MacHugh, D.E., Cunningham, E.P. & Loftus, R.T. 1996. Mitochondrial diversity and the origins of African and European cattle. Proceedings of the National Academy of Sciences, USA, 93: 5131–5135
Brown, P.O. & Botstein, D. 1999. Exploring the new world of the genome with DNA microarrays. Nature Genetics, 21(1 Suppl): 33–37.
Bulfield, G. 2000. Farm animal biotechnology. Trends in Biotechnology, 18: 10–13.
Cunningham, E.P. 1999. The application of biotechnologies to enhance animal production in different farming systems. Livestock Production Science, 58: 1–24.
Cunningham, E.P. (ed). 2003. After BSE — A future for the European livestock sector? EAAP Publication, No. 108.
Cunningham, E.P. & Meghen, C.M. 2001. Biological identification systems: genetic markers. OIE Review of Science and Technology, 20: 491–499.
Cunningham, E.P., Dooley, J.J., Splan, R.K. & Bradley, D.G. 2001. Microsatellite diversity, pedigree relatedness and the contributions of founder lineages to thoroughbred horses. Animal Genetics, 32: 360–364.
Dekkers, J.C.M. & Hospital, F. 2002. The use of molecular genetics in the improvement of agricultural populations. Nature Reviews Genetics, 3: 22–32.
Delgado, C., Rosengrant, M., Steinfeld, H., Ehui, S., & Courbois, C. 1999. Livestock in 2020. The next food revolution. IFPRI/FAO/ILRI.
Etherton, T.D. and a team of nine scientists. 2003. Biotechnology in animal agriculture: An overview. CAST Issue Paper, No. 23.
EU [European Union]. 2003. Overview report of a series of missions carried out in all member states during 2002 in order to evaluate the operation of controls over the traceability and labelling of beef and minced beef. DG Sanco Directorate F, Report 9505/2003.
FAO [Food and Agriculture Organization of the United Nations]. 2004. Domestic Animal Diversity Information System (DAD-IS). See: www.fao.org/dad-is.
Georges, M. 2001. Recent progress in livestock genomics and potential impact on breeding programs. Theriogenology, 55: 15–21.
Hill, E.W., Bradley, D.G., El-Barody, M.A., Ertugrul, O., Splan, R.K., Zakharov, I. & Cunningham, E.P. 2002. History and integrity of thoroughbred dam lines revealed in equine mtDNA variation. Animal Genetics, 33: 287–294.
Kerr, D.E., Wellnitz, O., Mitra, A. & Wall, R.J. 2002. Potential transgenic animals for agriculture. In: Proceedings of the 53rd EAAP Meeting. Cairo, September 2002.
Lander E.S. 1999. Array of hope. Nature Genetics, 21(1 Suppl): 3–4.
Loftus, R.T., MacHugh, D.E., Bradley, D.G., Sharp, P.M. & Cunningham, E.P. 1994. Evidence for 2 independent domestications of cattle. Proceedings of the National Academy of Sciences, USA, 91: 2757–2761.
MacHugh, D.E., Loftus, R.T., Bradley, D.G., Sharp, P.M. & Cunningham, E.P. 1994. Microsatellite DNA variation within and among European cattle breeds. Proceedings of the Royal Society of London, Series B, Biology, 256 (1345): 25–31.
MacHugh, D.E., Shriver, M.D., Loftus, R.T., Cunningham, E.P. & Bradley, D.G. 1997. Microsatellite DNA variation and the evolution, domestication and phylogeography of taurine and Zebu cattle (Bos taurus and Bos indicus). Genetics, 146: 1071–1086.
Niemann, H., Rath, D. & Wrenzycki, C. 2003. Advances in biotechnology: new tools in future pig production for agriculture and biomedicine. Reproduction in Domestic Animals, 38: 82–89.
Norris, A.T., Bradley, D.G. & Cunningham, E.P. 2000. Parentage and relatedness determination in farmed Atlantic salmon (Salmo salar) using microsatellite markers. Aquaculture, 182: 73–83.
O’Brien, S.J., Menotti-Raymond, M., Murphy, W.J., Nash, W.G., Wienberg, J., Stanyon, R., Copeland, N.G., Jenkins, N.A., Womack, J.E. & Graves, J.A.M. 1999. The promise of comparative genomics in mammals. Science, 286(5439): 458–462, 479-481.
Prather, R.S., Hawley, R.J., Carter, D.B., Lai, L. & Greenstein, J.L. 2003. Transgenic swine for biomedicine and agriculture. Theriogenology, 59(1): 115–123.
Rutledge, J.J. 2001. Greek temples, tropical kine and recombinant load. Livestock Production Science. 68: 171–179.
Troy, C.S., MacHugh, D.E., Bailey, J.F., Magee, D.A., Loftus, R.T., Cunningham, E.P., Chamberlain, A.T., Sykes, B.C., Bradley, D.G. 2001. Genetic evidence for Near-Eastern origins of European cattle. Nature, 410(6832): 108891.
Yilma, T., Ahmad, S., Jones, L., Ngotho, R., Wamwai, H., Berhanu, B., Mebratu, G., Berhe, G., Diop, M., Sarr, J., Aziz, F. & Verardi, P. 2003. Inexpensive vaccines and rapid diagnostic kits tailor-made for the global eradication of rinderpest. pp. 99–111, in: F. Brown and J.A. Roth (eds). Vaccines for OIE List A and Emerging Animal Diseases. Proceedings of the International SymposiumAmes, Iowa16–18 September 2002. [Developments in Biologicals, No. 114]. Basle, Switzerland: Karger.
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Cunningham, E. (2005). Gene-based Technologies for Livestock Industries in the 3rd Millennium. In: Makkar, H.P., Viljoen, G.J. (eds) Applications of Gene-Based Technologies for Improving Animal Production and Health in Developing Countries. Springer, Dordrecht. https://doi.org/10.1007/1-4020-3312-5_5
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