Abstract
Over the past two decades, the trickle of data emerging from DNA sequencing projects has increased to a flood. For example, by early 2003 there were over 36 billion bases of DNA sequence publicly available. New molecular marker technologies have similarly resulted in a huge increase in the availability of detailed genetic maps of model organisms and crop species. These advances have necessitated the development of bioinformatics tools for curation, dissemination, analysis and comparison of genome data, facilitated by the pace of improvement in computing power and storage capacity. Many genome databases use the object-oriented ACEDB database management system. ACEDB offers powerful search tools and sophisticated cross-linking between data items, and has tools to facilitate comparative map and sequence displays. Because many crops, including most forages and turf, have large genomes they are unlikely to be sequenced in the near future. However, comparative genomics offers breeders many opportunities for targeted molecular breeding approaches, and there are now several major of comparative plant genome bioinformatics projects worldwide. Bioinformatics can assist in development or selection of markers associated with quantitative traits, and identification and cloning of candidate genes for control of important characters. Post-genomic techniques such as transcriptomics and metabolomics, which can aid characterisation of mapping populations and varieties, also require bioinformatics tools for the curation, analysis and displaying of the very large data sets which they can generate.
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References
C. elegans Sequencing Consortium (1998) Genome Sequence of the Nematode C. elegans: A Platform for Investigating Biology. Science 1998: 2012–2018. (Note: the full author listing for this publication, consisting of over 350 names, is available from http://www.sanger.ac.uk/Projects/C_elegans/)
Dicks J, Anderson M, Cardle L, Cartinhour S, Couchman M, Davenport G, Dickson J, Gale MD, Marshall D, May S, McWilliam H, O’Malia A, Ougham HJ, Trick M, Walsh S, Waugh R (2000) UK CropNet: a collection of databases and bioinformatics resources for crop plant genomics. Nucleic Acids Res. 28: 104–107.
Dunwell JM, Moya-Leon MA, Herrera R (2001) Transcriptome analysis and crop improvement. Biol. Res. 34: 153–164.
Fiehn O (2002) Metabolomics — the link between genotypes and phenotypes. Plant Mol. Biol. 48: 155–171.
Garcia-Hernandez M, Berardini TZ, Chen G, Crist D, Doyle A, Huala E, Knee E, Lambrecht M, Miller N, Mueller LA, Mundodi S, Reiser L, Rhee SY, Scholl R, Tacklind J, Weems DC, Wu Y, Xu I, Yoo D, Yoon J, Zhang P (2002) TAIR: a resource for integrated Arabidopsis data. Funct. Integr. Genomics 2: 239–253.
Guo YM, Shen SH, Jing YX, Kuang TY (2002) Plant proteomics in the post-genomic era. Acta Bot. Sin. 44: 631–641.
Jones ES, Mahoney NL, Hayward MD, Armstead IP, Jones JG, Humphreys MO, King IP, Kishida T, Yamada T, Balfourier F, Charmet G, Forster JW (2002) An enhanced molecular marker based genetic map of perennial ryegrass (Lolium perenne) reveals comparative relationships with other Poaceae genomes. Genome 45: 282–295.
Kanehisa M, Bork P (2003) Bioinformatics in the post-sequence era. Nat. Genet. 33: 305–310 Suppl.
Lamblin AJ, Crow JA, Johnson JE, Silverstein KAT, Kunau TM, Kilian A, Benz D, Stromvik M, Endré G, VandenBosch KA, Cook DR, Young ND, Retzel EF (2003) MtDB: a database for personalized data mining of the model legume Medicago truncatula transcriptome. Nucleic Acids Res. 31: 196–201.
Luscombe NM, Greenbaum D, Gerstein M (2001) What is bioinformatics? A proposed definition and overview of the field. Methods Inf. Med. 40: 346–58.
Polacco ML, Coe E, Fang, Z, Hancock DC, Sanchez-Villeda H, Schroeder S (2002) MaizeDB — a functional genomics perspective. Comp. Funct. Genom. 3:128–131.
Rudd S, Mewes HW, Mayer KFX (2003) Sputnik: a database platform for comparative plant genomics. Nucleic Acids Res. 31: 128–132.
Samson D, Legeai F, Karsenty E, Reboux S, Veyrieras JB, Just J, Barillot E (2003) GenoPlante-Info (GPI): a collection of databases and bioinformatics resources for plant genomics. Nucleic Acids Res. 31: 179–182.
Schoof H, Zaccaria P, Gundlach H, Lemcke K, Rudd S, Kolesov G, Arnold R, Mewes HW, Mayer KF (2002) MIPS Arabidopsis thaliana Database (MAtDB): an integrated biological knowledge resource based on the first complete plant genome. Nucleic Acids Res. 30: 91–93.
Sumner LW, Mendes P, Dixon RA (2003) Plant metabolomics: large-scale phytochemistry in the functional genomics era. Phyrtochem. 62: 817–836.
Thorogood D, Kaiser WJ, Jones JG, Armstead IP (2002) Self-incompatibility in ryegrass 12 Genotyping and mapping the S and Z loci of Lolium perenne L Heredity 88: 385–390.
van Deynze AE, Sorrells ME, Park WD, Ayres NM, Fu H, Cartinhour SW, Paul E, McCouch SR (1998) Anchor probes for comparative mapping of grass genera. Theor. Appl. Genet. 97: 356–369.
Ware D, Jaiswal P, Ni JJ, Pan XK, Chang K, Clark K, Teytelman L, Schmidt S, Zhao W, Cartinhour S, McCouch S, Stein L (2002) Gramene: a resource for comparative grass genomics. Nucleic Acids Res. 30: 103–105.
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Ougham, H.J., Huang, L.S. (2004). Bioinformatics: Bringing Data to a Usable Form for Breeders. In: Hopkins, A., Wang, ZY., Mian, R., Sledge, M., Barker, R.E. (eds) Molecular Breeding of Forage and Turf. Developments in Plant Breeding, vol 11. Springer, Dordrecht. https://doi.org/10.1007/1-4020-2591-2_22
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DOI: https://doi.org/10.1007/1-4020-2591-2_22
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