Skip to main content

Functional Assessment of Human Brain with Non-Invasive Electrophysiological Methods

  • Chapter
Brain Damage and Repair
  • 344 Accesses

Summary

Conventional electroencephalography (EEG) and event-related brain measurements (ERPs) provide unique non-invasive approaches to study in-vivo human cerebral functions with a temporal resolution of milliseconds. These techniques have proved to be helpful to assess cognitive abilities, differentiate between brain states, and support the diagnosis in neurological and psychiatric diseases. Human neurophysiological correlates of learning have also been revealed by task-dependent increases in gamma EEG coherence and amplitude modulations of specific brain evoked components at different levels of information processing. Changes in spontaneous and evoked brain responses can be also used to explore the role of sleep in both sensory function and memory consolidation. All together, these lines of evidence suggest that EEG and ERP techniques will remain omnipresent in those research and clinical environments devoted to assess certain human brain functions with non-invasive neurophysiological techniques.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Adler, L.E., Olincy, A., Waldo, M., Harris, J.G., Griffith, J., Stevens, K., Flach, K., Nagamoto, H., Bickford, P., Leonard, S. & Freedman, R. (1998) Schizophrenia, sensory gating, and nicotinic receptors. Schizophr. Bull., 24, 189–202.

    Article  PubMed  CAS  Google Scholar 

  • Anderson, M.C. & Spellman, B.A. (1995) On the status of inhibitory mechanisms in cognition: memory retrieval as a model case. Psychol. Rev., 102, 68–100.

    Article  PubMed  CAS  Google Scholar 

  • Atienza, M. & Cantero, J.L. (2001) Complex sound processing during human REM sleep by recovering information from long-term memory as revealed by the mismatch negativity (MMN). Brain Res., 901, 151–160.

    Article  PubMed  CAS  Google Scholar 

  • Atienza, M., Cantero, J. L. & Dominguez-Marin, E. (2002) The time course of neural changes underlying auditory perceptual learning. Learn. Mem., 9, 138–150.

    Article  PubMed Central  PubMed  Google Scholar 

  • Atienza, M., Cantero, J. L. & Stickgold R. (in press) Posttraining sleep enhances automaticity in perceptual discrimination. J. Cogn. Neurosci.

    Google Scholar 

  • Bergey, G.K. & Franaszczuk, P.J. (2001) Epileptic seizures are characterized by changing signal complexity. Clin. Neurophysiol., 112, 241–249.

    Article  PubMed  CAS  Google Scholar 

  • Brualla, J., Romero, M.F., Serrano, M. & Valdizan, J.R. (1998) Auditory event-related potentials to semantic priming during sleep. Electroencephalogr. Clin. Neurophysiol., 108, 283–290.

    Article  PubMed  CAS  Google Scholar 

  • Cantero, J.L., Atienza, M. & Salas, R.M. (2002a) Effects of waking-auditory stimulation on human sleep architecture. Behav. Brain Res., 128, 53–59.

    Article  PubMed  Google Scholar 

  • Cantero, J.L., Atienza, M., Salas, R.M. & Dominguez-Marin, E. (2002b) Effects of prolonged waking- auditory stimulation on electroencephalogram synchronization and cortical coherence during subsequent slow-wave sleep. J. Neurosci, 22, 4702–4708.

    PubMed  CAS  Google Scholar 

  • Chiappa, K.H. (1989). Evoked potentials in clinical medicine (2nd ed.). Raven Press, New York.

    Google Scholar 

  • Cote, K.A. & Campbell, K.B. (1999) P300 to high intensity stimuli during REM sleep. Clin. Neurophysiol., 110, 1345–1350.

    Article  PubMed  CAS  Google Scholar 

  • Fulton, M.K., Armitage, R. & Rush, A.J. (2000) Sleep electroencephalographic coherence abnormalities in individuals at high risk for depression: a pilot study. Biol. Psychiatry, 47, 618–625.

    Article  PubMed  CAS  Google Scholar 

  • Gilbert, C. D. (1994) Learning. Neuronal dynamics and perceptual learning. Curr. Biol., 4, 627–629.

    Article  PubMed  CAS  Google Scholar 

  • Gilbert, C. D., Sigman, M. & Crist, R. E. (2001) The neural basis of perceptual learning. Neuron, 31, 681–697.

    Article  PubMed  CAS  Google Scholar 

  • Gruber, T., Muller, M.M. & Keil, A. (2002) Modulation of induced gamma band responses in a perceptual learning task in the human EEG. J. Cogn. Neurosci., 14, 732–744.

    Article  PubMed  Google Scholar 

  • Javitt, D.C. (2000) Intracortical mechanisms of mismatch negativity dysfunction in schizophrenia. Audio;. Neurootol., 5, 207–215.

    Article  CAS  Google Scholar 

  • Javitt, D.C., Shelley, A.-M., Silipo, G., Lieberman, J.A. (in press) Deficits in AX-continuous performance test and mismatch negativity generation in schizophrenia: defining the pattern.

    Google Scholar 

  • Jouny, C.C., Franaszczuk, P.J. & Bergey, G.K. (2003) Characterization of epileptic seizure dynamics using Gabor atom density. Clin. Neurophysiol., 114, 426–437.

    Article  PubMed  Google Scholar 

  • Kartier, H., Disk, DJ. & Borbely, A.A. (1994) Effect of unilateral somatosensory stimulation prior to sleep on the sleep EEG in humans. J. Sleep Res., 3, 159–164.

    Article  Google Scholar 

  • Kane, N.M., Curry, S.H., Butler, S.R. & Cummins, B.H. (1993) Electrophysiological indicator of awakening from coma. Lancet, 341, 688.

    Article  PubMed  CAS  Google Scholar 

  • Keil, A., Muller, M.M., Gruber, T., Wienbruch, C. & Elbert, T. (2001) Human large-scale oscillatory brain activity during an operant shaping procedure. Brain Res. Cogn. Brain Res., 12, 397–407.

    Article  CAS  Google Scholar 

  • Kisley, M.A., Olincy, A. & Freedman, R. (2001) The effect of state on sensory gating: comparison of waking, REM and non-REM sleep. Clin. Neurophysiol., 112, 1154–1165.

    Article  PubMed  CAS  Google Scholar 

  • Kisley, M.A., Olincy, A., Robbins, E., Polk, S.D., Adler, E.E., Waldo, M.C. & Freedman, R. (2003) Sensory gating impairment associated with schizophrenia persists into REM sleep. Psychophysiology, 40, 29–38.

    Article  PubMed  Google Scholar 

  • Krueger, J.M., Obal, F., Kapas, L. & Fang, J. (1995) Brain organization and sleep function. Behav. Brain Res., 69, 177–185.

    Article  PubMed  CAS  Google Scholar 

  • Kuks, J.B.M., Vos, J.E. & O’Brien, M.J. (1987) Coherence patterns of the infant sleep EEG in absence of the corpus callosum. Electroenceph. clin. Neurophysiol., 66, 8–14.

    CAS  Google Scholar 

  • Leppänen, P.H.T., Pihko, E., Eklund, K.M., et al. (in press) Brain responses reveal speech processing differences in infants at a risk for dyslexia.

    Google Scholar 

  • Leuchter, A.F., Newton, T.F., Cook, I.A., Walter, D.O., Rosenberg-Thompson, S. & Lachenbruch, P.A. (1992) Changes in brain functional connectivity in Alzheimer-type and multi-infarct dementia. Brain, 115, 1543–1561.

    Article  PubMed  Google Scholar 

  • Leuchter, A.F., Cook, I.A., Uijtdehaage, S.H., Dunkin, J., Lufkin, R.B., Anderson-Hanley, C., Abrams, M., Rosenberg-Thompson, S., O’Hara, R., Simon, S.L., Osato, S. & Babaie, A. (1997) Brain structure and function and the outcomes of treatment for depression. J. Clin. Psychiatry, 58, 22–31.

    Article  PubMed  Google Scholar 

  • Le Van Quyen, M., Martinerie, J., Navarro, V., Boon, P., D’Have, M., Adam, C., Renault, B., Varela, F. & Baulac, M. (2001) Anticipation of epileptic seizures from standard EEG recordings. Lancet, 357, 183–188.

    Article  Google Scholar 

  • Locatelli, T., Cursi, M, Liberati, D., Franceschi, M. & Comi, G. (1998) EEG coherence in Alzheimer’s disease. Electroenceph. clin. Neurophysiol., 106, 229–237.

    CAS  Google Scholar 

  • Mann, K., Maier, W., Franke, P., Roschke, J. & Gansicke, M. (1997) Intra- and interhemispheric electroencephalogram coherence in siblings discordant for schizophrenia and healthy volunteers. Biol. Psychiatry, 42, 655–663.

    Article  PubMed  CAS  Google Scholar 

  • McCarley, R.W., Niznikiewicz, M.A., Salisbury, D.F., Nestor, P.G., O’Donnell, B.F., Hirayasu, Y., Grunze, H., Greene, R.W. & Shenton, M.E. (1999) Cognitive dysfunction in schizophrenia: unifying basic research and clinical aspects. Eur. Arch. Psychiatry Clin. Neurosci., 249, 69–82.

    Article  PubMed Central  PubMed  Google Scholar 

  • Merrin, E.L., Floyd, T.C. & Fein, G. (1989) EEG coherence in unmedicated schizophrenic patients. Biol. Psychiatry, 25, 60–66.

    Article  PubMed  CAS  Google Scholar 

  • Michie, P.T., Kent, A., Stienstra, R., Castine, R., Johnston, J., Dedman, K., Wichmann, H., Box, J., Rock, D., Rutherford, E. & Jablensky, A. (2002) Phenotypic markers as risk factors in schizophrenia: neurocognitive functions. Aust. N. Z. J. Psychiatry, 34, S74–85.

    Article  Google Scholar 

  • Miltner, W.H., Braun, C., Arnold, M., Witte, H. & Taub, E. (1999) Coherence of gamma-band EEG activity as a basis for associative learning. Nature, 397, 434–436.

    Article  PubMed  CAS  Google Scholar 

  • Montplaisir, J., Nielsen, T., Cote, J. Boivin, D., Rouleau, I. & Lapierre, G. (1990) Interhemispheric EEG coherence before and after partial callosotomy. Clin. Electroenceph., 21, 42–47.

    Article  CAS  Google Scholar 

  • Morrison, J.H., Scherr, S., Lewis, D.A., Campbell, M.J., Bloom, F.E., Rogers, J. & Benoit, R. (1986) The laminar and regional distribution of neocortical somatostatin and neuritic plaques: implications for Alzheimer’s disease as a global neocortical disconnection syndrome. In A.B. Scheibel, A.F. Wechsler & M.A. Brazier (Eds.), Morrison, J.H., Scherr, S., Lewis, D.A., Campbell, M.J., Bloom, F.E., Rogers, J. & Benoit, R, (pp. 115–131). Academic Press, Orlando.

    Google Scholar 

  • Näätänen, R. (2003) Mismatch negativity: clinical research and possible applications. Int. J. Psychophysiology, 48, 179–188.

    Article  Google Scholar 

  • Näätänen, R., Tervaniemi, M., Sussman, E., Paavilainen, P. & Winkler, I. (2001) “Primitive intelligence” in the auditory cortex. Trends Neurosci., 24, 283–288.

    Article  PubMed  Google Scholar 

  • Niedermeyer, E. & Lopes da Silva, F.H. (1993) Electroencephalography: Basic principles, clinical applications, and related fields (3rd ed.). Lippincott Williams &; Wilkins, Baltimore.

    Google Scholar 

  • Nielsen, T., Montplaisir, J. & Lassonde, M. (1993) Decreased interhemispheric EEG coherence during sleep in agenesis of the corpus callosum. Eur. Neurol., 33, 173–176.

    Article  PubMed  CAS  Google Scholar 

  • O’Donnell, B.F., McCarley, R.W., Potts, G.F., Salisbury, D.F., Nestor, P.G., Niznukiewicz, M.A., Barnard, J., Shen, Z.J., Weinstern, D.M., Bookstein, F.L. & Shenton, M.E. (1999) Identification of neural circuits underlying P300 abnormalities in schizophrenia. Psychophysiology, 36, 388–398.

    Article  PubMed Central  PubMed  Google Scholar 

  • Pearson, R.C., Esiri, M.M., Hiorns, R.W., Wilcock, G.K. & Powell, T.P. (1985) Anatomical correlates of the distribution of the pathological changes in the neocortex in Alzheimer’s disease. Proc. Natl. Acad. Sci. USA, 82, 4531–4534.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  • Pekkonen, E. (2000) Mismatch negativity in aging and in Alzheimer’s and Parkinson’s diseases. Audiol. Neurootol., 5, 216–224.

    Article  PubMed  CAS  Google Scholar 

  • Pekkonen, E., Jousmaki, V., Kononen, M., Reinikainen, K. & Partanen, J. (1994) Auditory sensory memory impairment in Alzheimer’s disease: an event-related potential study. Neuroreport, 5, 2537–2540.

    Article  PubMed  CAS  Google Scholar 

  • Senhadji, L. & Wendung, F. (2002) Epileptic transient detection: wavelets and time-frequency approaches. Neurophysiol. Clin., 32, 175–192.

    Article  PubMed  Google Scholar 

  • Serrien, D.J. & Brown, P. (2003) The integration of cortical and behavioural dynamics during initial learning of a motor task. Eur. J. Neurosci., 17, 1098–1104.

    Article  PubMed  Google Scholar 

  • Song, Y., Ding, Y., Fan, S. & Chen, L. (2002) An event-related potential study on visual perceptual learning under short-term and long-term training conditions. Neuroreport, 13, 2053–2057.

    Article  PubMed  Google Scholar 

  • Tremblay, K., Kraus, N., & McGee, T. (1998) The time course of auditory perceptual learning: neurophysiological changes during speech-sound training. Neuroreport, 9, 3557–3560.

    Article  PubMed  CAS  Google Scholar 

  • Varela, F., Lachaux J.F., Rodriguez, E & Martinerie, J. (2001) The brainweb: phase synchronization and large-scale integration. Nature Rev. Neurosci., 2, 229–239.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2004 Springer Science+Business Media Dordrecht

About this chapter

Cite this chapter

Cantero, J.L., Atienza, M. (2004). Functional Assessment of Human Brain with Non-Invasive Electrophysiological Methods. In: Herdegen, T., Delgado-García, J. (eds) Brain Damage and Repair. Springer, Dordrecht. https://doi.org/10.1007/1-4020-2541-6_41

Download citation

  • DOI: https://doi.org/10.1007/1-4020-2541-6_41

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-90-481-6538-4

  • Online ISBN: 978-1-4020-2541-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics