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General Remarks on the Bridging Between Basic Research and Clinics

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Brain Damage and Repair
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Summary

Transfer of basic research results to clinical application with generation of novel treatment options for neurodegenerative diseases is an important issue but appeared to be extremely difficult in the past. This introductory chapter addresses these difficulties embracing health care expenses, basic research as well as therapeutic options in the hospital with their limitations and possibilities.

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References

  • Alnemri ES, Livingston DJ, Nicholson DW, Salvesen G, Thornberry NA, Wong WW, Yuan J. (1996) Human ICE/CED-3 protease nomenclature. Cell 87(2): 171.

    Article  PubMed  CAS  Google Scholar 

  • Andersen JK. (2001) Does neuronal loss in Parkinson’s disease involve programmed cell death? Bioessays 23(7):640–6.

    Article  PubMed  CAS  Google Scholar 

  • Antuono P, Beyer J. (1999) The burden of dementia. A medical and research perspective. Theor Med Bioeth.20(l):3–13.

    Article  PubMed  CAS  Google Scholar 

  • Baekelandt V, De Strooper B, Nuttin B, Debyser Z. (2000) Gene therapeutic strategies for neurodegenerative diseases. Curr Opin Mol Ther. 2(5):540–54.

    PubMed  CAS  Google Scholar 

  • Barde YA. (1989) Trophic factors and neuronal survival. Neuron. 2(6): 1525–34.

    Article  PubMed  CAS  Google Scholar 

  • Becker-Hapak M, McAllister SS, Dowdy SF. (2001) TAT-mediated protein transduction into mammalian cells. Methods. 24(3):247–56.

    Article  PubMed  CAS  Google Scholar 

  • Choi DW. (1992) Excitotoxic cell death. J Neurobiol. 23(9):1261–76.

    Article  PubMed  CAS  Google Scholar 

  • Dirnagl U, Iadecola C., Moskowitz MA. (1999) Pathobiology of ischaemic stroke: an integrated view. Trends Neurosci. 22(9):391–7.

    Article  PubMed  CAS  Google Scholar 

  • Estibeiro P, Godfray J. (2001) Antisense as a neuroscience tool and therapeutic agent. Trends Neurosci. 24(11 Suppl):S56–62.

    Article  Google Scholar 

  • Ford KG, Souberbielle BE, Darling D, Farzaneh F. (2001) Protein transduction: an alternative to genetic intervention? Gene Ther. 8(1): 1–4.

    Article  PubMed  CAS  Google Scholar 

  • Gortelmeyer R, Erbler H. (1992) Memantine in the treatment of mild to moderate dementia syndrome. A double-blind placebo-controlled study. Arzneimittelforschung. 42(7):904–13.

    PubMed  CAS  Google Scholar 

  • Kroemer G, Reed JC. (2000) Mitochondrial control of cell death. Nat Med. 6(5):513–9.

    Article  PubMed  CAS  Google Scholar 

  • Lindblad K, Schalling M. (1999) Expanded repeat sequences and disease. Semin Neurol. 19(3):289–99.

    Article  PubMed  CAS  Google Scholar 

  • Oertel WH, Bandmann O. (1999) Multiple system atrophy. J Neural Transm Suppl. 56:155–64.

    Article  PubMed  CAS  Google Scholar 

  • Payne KA, Huybrechts KF, Caro J, Craig Green TJ, Klittich WS. (2002) Long Term Cost-of-Illness in Stroke: An International Review. Pharmacoeconomics. 20(12):813–25.

    Article  PubMed  Google Scholar 

  • Roy N, Mahadevan MS, McLean M, Shutler G, Yaraghi Z, Farahani R, Baird S, Besner-Johnston A, Lefebvre C., Kang X, et al. (1995) The gene for neuronal apoptosis inhibitory protein is partially deleted in individuals with spinal muscular atrophy. Cell. 80(1): 167–78.

    Article  PubMed  CAS  Google Scholar 

  • Sanchez Mejia RO, Friedlander RM. (2001) Caspases in Huntington’s disease. Neuroscientist. 7(6):480–9

    Article  PubMed  CAS  Google Scholar 

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© 2004 Springer Science+Business Media Dordrecht

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Kermer, P., Bähr, M. (2004). General Remarks on the Bridging Between Basic Research and Clinics. In: Herdegen, T., Delgado-García, J. (eds) Brain Damage and Repair. Springer, Dordrecht. https://doi.org/10.1007/1-4020-2541-6_32

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  • DOI: https://doi.org/10.1007/1-4020-2541-6_32

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-90-481-6538-4

  • Online ISBN: 978-1-4020-2541-9

  • eBook Packages: Springer Book Archive

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