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Migration Disorders and Epilepsy

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Brain Damage and Repair

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Summary

Normal development of the cerebral cortex requires radial migration of cortical neurons from the ventricular zone towards the pial surface. During recent years new insights into the different steps of cortical layer formation have been gained from the study of genetic disorders in humans and from the investigation of spontaneous or engineered mouse mutants. From these studies individual molecules have been identified which are crucially involved in the different steps of migration, i.e. migration onset, the actual migration along radial glial fibers and neuronal positioning. Here we will review current knowledge of the molecular pathways governing correct cortical layer formation which is a prerequisite for normal brain function.

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Authors and Affiliations

  1. Institute of Anatomy and Cell Biology, University of Freiburg, Germany

    C. A. Haas & M. Frotscher

Authors
  1. C. A. Haas
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  2. M. Frotscher
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Editors and Affiliations

  1. Institute of Pharmacology, University of Kiel, Kiel, Germany

    T. Herdegen

  2. Department of Neurosciences, University Pablo de Olavide, Sevilla, Spain

    J. Delgado-García

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© 2004 Springer Science+Business Media Dordrecht

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Haas, C.A., Frotscher, M. (2004). Migration Disorders and Epilepsy. In: Herdegen, T., Delgado-García, J. (eds) Brain Damage and Repair. Springer, Dordrecht. https://doi.org/10.1007/1-4020-2541-6_25

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  • DOI: https://doi.org/10.1007/1-4020-2541-6_25

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-90-481-6538-4

  • Online ISBN: 978-1-4020-2541-9

  • eBook Packages: Springer Book Archive

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