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Neural Plasticity and Central Nervous System Lesion Repair

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Brain Damage and Repair

Summary

In the previous chapter, the relationships between neural plasticity and functional processes underlying learning has been described. In this chapter, I will consider the main mechanisms involved in neural tissue repair after its traumatic, or cytotoxic lesion. A particular attention will be paid to available information for reducing secondary neuronal death, and to the molecular and sub-cellular processes involved in glial scar formation and in the inhibition of axonal growth. The possible contribution of aldynoglia, or growth-promoting glia, to axonal regrowth will also be considered. In particular, a detailed presentation will be made of ensheathing glia role in axon section repair in the central and peripheral nervous systems.

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Authors and Affiliations

  1. Institute Cajal, CSIC, Madrid, Spain

    M. Nieto-Sampedro

  2. Hospital Nacional de Parapléjicos, Unit of Experimental Neurology, SESCAM, Toledo, Spain

    M. Nieto-Sampedro

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  1. M. Nieto-Sampedro
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Editors and Affiliations

  1. Institute of Pharmacology, University of Kiel, Kiel, Germany

    T. Herdegen

  2. Department of Neurosciences, University Pablo de Olavide, Sevilla, Spain

    J. Delgado-García

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Nieto-Sampedro, M. (2004). Neural Plasticity and Central Nervous System Lesion Repair. In: Herdegen, T., Delgado-García, J. (eds) Brain Damage and Repair. Springer, Dordrecht. https://doi.org/10.1007/1-4020-2541-6_21

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  • DOI: https://doi.org/10.1007/1-4020-2541-6_21

  • Publisher Name: Springer, Dordrecht

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