Neural Plasticity and Regeneration: Myths and Expectations

  • J. M. Delgado-García
  • A. Gruart


In this chapter, we will make a short revision of the concepts of neural plasticity and regeneration, and their relationships with processes such as motor learning and functional recovery following a lesion of the central or peripheral nervous systems. Particular attention will be paid to the actual morphological and physiological limits between plastic and regenerative processes in the adult mammal’s brain, as well as to their potential functionality and adaptability. A precise delimitation will be trace between regenerative phenomena and compensatory mechanisms and other cognitive activities, which are sometimes confused with neural plastic processes. As a practical support to the concepts proposed here, some illustrative examples, collected from animal experimentation carried out in our laboratory, will be described briefly.


Conditioned Stimulus Facial Nerve Neural Plasticity Adult Mammal Central Nervous System Neuron 
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  1. Barron KD (1989) Neuronal responses to axotomy: consequences and possibilities for rescue from permanent atrophy and cell death. In: Neural Regeneration and Transplantation (Ed. FJ Seil), pp. 79–100. Alan R Liss Inc, New York.Google Scholar
  2. Bliss TVP and Collingridge GL (1993) A synaptic model of memory: long-term potentiation in the hippocampus. Nature, 361, 31–39.PubMedCrossRefGoogle Scholar
  3. Bothwell M (1995) Functional interactions of neurotrophins and neurotrophin receptors. Annual Review of Neuroscience, 18, 223–253.PubMedCrossRefGoogle Scholar
  4. Carlin RK and Siekevitz P (1983) Plasticity in the central nervous system: do synapses divide? Proceedings of the National Academy of Sciences (USA), 80, 3517–3521.CrossRefGoogle Scholar
  5. Cotman CW and Nieto-Sampedro M (1984) Cell biology of synaptic plasticity. Science, 225, 1287–1294.PubMedCrossRefGoogle Scholar
  6. Czéh G, Gallego R, Kudo N and Kuno M (1978) Evidence for the maintenance of motoneurone properties by muscle activity. The Journal of Physiology (London), 281, 239–252.Google Scholar
  7. De la Cruz RR, Pastor AM and Delgado-García JM (1996) Influence of the postsynaptic target on the functional properties of neurons in the adult mammalian central nervous system. Reviews in the Neurosciences, 1, 115–149.Google Scholar
  8. De la Cruz RR, Delgado-Garcia JM and Pastor AM (2000) Discharge characteristics of axotomized abducens internuclear neurons in the adult cat. Journal of Comparative Neurology, 427, 391–404.CrossRefGoogle Scholar
  9. Delgado-Garcia JM (1998) Output-to-input approach to neural plasticity in vestibular pathways. Otolaryngology-Head and Neck Surgery, 119, 221–230.PubMedCrossRefGoogle Scholar
  10. Delgado-Garcia JM (2003) Plasticidad y regeneración neuronal: mitos y expectativas. Medicina Intensiva Online 3, 289–295.Google Scholar
  11. Delgado-García JM and Gruart A (2002) The role of interpositus nucleus in eyelid conditioned responses. The Cerebellum, 1, 289–308.PubMedCrossRefGoogle Scholar
  12. Delgado-Garcia JM, del Pozo F, Spencer R and Baker R (1988) Behavior of neurons in the abducens nucleus of the alert cat—III. Axotomized motoneurons. Neuroscience, 24, 143–160.PubMedCrossRefGoogle Scholar
  13. Edwards FA (1995) LTP—a structural model to explain inconsistencies. Trends in the Neurosciences, 18, 250–255.CrossRefGoogle Scholar
  14. Geinisman Y, Berry RW, Disterhoft JF, Power JM and Van der Zee EA (2001) Associative learning elicits the formation of multiple-synapse boutons. Journal of Neuroscience, 21, 5568–5573.PubMedGoogle Scholar
  15. Gruart A, Blázquez P and Delgado-Garcia JM (1995) Kinematics of spontaneous, reflex, and conditioned eyelid movements in the alert cat. Journal of Neurophysiology, 74, 226–248.PubMedGoogle Scholar
  16. Gruart A, Guillazo-Blanch G, Fernández-Mas R, Jiménez-Díaz L and Delgado-Garcia JM (2000) Cerebellar posterior interpositus nucleus as an enhancer of classically conditioned eyelid responses in alert cats. Journal of Neurophysiology, 84, 2680–2690.PubMedGoogle Scholar
  17. Gruart A, Gunkel A, Neiss WF, Angelov DN, Stennert E and Delgado-Garcia JM (1996) Changes in eye blink responses following hypoglossal-facial anastomosis in the cat: evidence of adult mammal motoneuron unadaptability to new motor tasks. Neuroscience, 73, 233–247.PubMedCrossRefGoogle Scholar
  18. Gruart A, Streppel M, Guntinas-Lichius O, Angelov DN, Neiss WF and Delgado-Garcia JM (2002) Motoneuron adaptability to new motor tasks following two types of facial-facial anastomosis in cats. Brain, 126, 115–133.CrossRefGoogle Scholar
  19. Gudino-Cabrera G, Pastor AM, de la Cruz RR, Delgado-Garcia JM and Nieto-Sampedro M (2000) Limits to the capacity of transplants of olfactory glia to promote axonal regrowth in the CNS. Neuroreport, 11, 467–471.PubMedCrossRefGoogle Scholar
  20. Hay don PG and Drapeau P (1995) From contact to connection: early events during synaptogenesis. Trends in the Neurosciences, 18, 196–201.CrossRefGoogle Scholar
  21. Johnson RD, Taylor JS, Mendell LM and Munson JB (1995) Rescue of motoneuron and muscle afferent function in cats by regeneration into skin. I. Properties of afférents. Journal of Neurophysiology, 73, 651–661.PubMedGoogle Scholar
  22. Kandel ER, Schwartz JH and Jessell TM (2000) Principles of Neural Science. McGraw-Hill, New York.Google Scholar
  23. Kirkwood A, Lee HK and Bear MF (1995) Co-regulation of long-term potentiation and experience- dependent synaptic plasticity in visual cortex by age and experience. Nature, 375, 328–331.PubMedCrossRefGoogle Scholar
  24. Kuno M, Miyata Y and Munoz-Martinez E J (1974) Differential reaction of fast and slow a-motoneurones to axotomy. The Journal of Physiology (London), 240, 725–739.Google Scholar
  25. Levi-Montalcini R (1982) Developmental neurobiology and the natural history of nerve growth factor. Annual Review of Neuroscience, 5, 341–362.PubMedCrossRefGoogle Scholar
  26. Lieberman AR (1971) The axon reaction: a review of the principal features of perikaryal responses to axon injury. International Review of Neurobiology, 14, 49–123.PubMedCrossRefGoogle Scholar
  27. Llinás R (2001) I of the Vortex. From Neurons to Self The MIT Press, Cambridge, MA.Google Scholar
  28. Malenka RC (1995) LTP and LTD: dynamic and interactive processes of synaptic plasticity. The Neuroscientist, 1, 35–42.CrossRefGoogle Scholar
  29. Morcuende S, Delgado-Garcia JM and Ugolini (2002) Neuronal premotor networks involved in eyelid responses: retrograde transneuronal tracing with rabies virus from the orbicularis oculi muscle in the rat. Journal of Neuroscience, 22, 8808–8818.PubMedGoogle Scholar
  30. Pastor AM, Delgado-Garcia JM, Martinez-Guijarro FJ, López-García C and de la Cruz RR (2000) Response of abducens internuclear neurons to axotomy in the adult cat. Journal of Comparative Neurology, 427, 370–390.PubMedCrossRefGoogle Scholar
  31. Pozo MA and Cerveró F (1993) Neurons in the rat spinal trigeminal complex driven by corneal nociceptors: receptive-field properties and effects of noxious stimulation of the cornea. Journal of Neurophysiology, 70, 2370–2378.PubMedGoogle Scholar
  32. Privat A, Chauvet N and Gimenez y Ribota M (1997) Repousse axonale et obstacle glial. Revieu de Neurologie (Paris), 153, 515–520.Google Scholar
  33. Purves D (1986) The trophic theory of neural connections. Harvard University Press, Cambridge, MA.Google Scholar
  34. Ramón y Cajal S (1911, 1972) Histologie du système nerveux de l’homme et des vertébrés, Vol 2. C.S.I.C, Madrid.Google Scholar
  35. Schnell L and Schwab ME (1990) Axonal regeneration in the rat spinal cord produced by an antibody against myelin-associated neurite growth inhibitors. Nature, 343, 269–272.PubMedCrossRefGoogle Scholar
  36. Selzer ME (1980) Regeneration of peripheral nerve. In: The Physiology of Peripheral Nerve Disease (Ed. AJ Summer), pp. 358–431. WB Saunders Company, Philadelphia.Google Scholar
  37. Sofroniew MV, Galletly NP, Isacson O and Svendsen CN (1990) Survival of adult basal forebrain cholinergic neurons after loss of target neurons. Science, 247, 338–342.PubMedCrossRefGoogle Scholar
  38. Sperry RW (1945) The problem of central nervous reorganization after nerve regeneration and muscle transposition. Quarterly Review of Biology, 20, 311–369.PubMedCrossRefGoogle Scholar
  39. Sunderland S S (1991) Nerve Injuries and their Repair. A Critical Appraisal. Churchill Livingstone, Edinburgh.Google Scholar
  40. Schwab ME (2002) Repairing the injured spinal cord. Science, 295, 1029–1031.PubMedCrossRefGoogle Scholar
  41. Takata, M (1993) Two types of inhibitory postsynaptic potentials in the hypoglossal motoneurons. Progress in Neurobiology, 40, 385–411.PubMedCrossRefGoogle Scholar
  42. Tsukahara N (1981) Synaptic plasticity in the mammalian central nervous system. Annual Review of Neuroscience, 4, 351–379PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 2004

Authors and Affiliations

  • J. M. Delgado-García
    • 1
  • A. Gruart
    • 1
  1. 1.Division of NeuroscienceUniversity Pablo de OlavideSevillaSpain

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