Skip to main content
SpringerLink
Log in
SpringerLink
Log in

Proteomics in Oncology: the Breast Cancer Experience

  • Chapter
Proteomics: Biomedical and Pharmaceutical Applications

  • 201 Accesses

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 179.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 229.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Adam P.J., Boyd R., Tyson K.L., Fletcher G.C., Stamps A., Hudson L., Poyser H.R., Redpath N., Griffiths M., Steers G., Harris A.L., Patel S., Berry J., Loader J.A., Townsend R.R., Daviet L., Legrain P., Parekh R., Terrett J.A., 2003, Comprehensive proteomic analysis of breast cancer cell membranes reveals unique proteins with potential roles in clinical cancer. J. Biol. Chem. 278: 6482–6489.

    Article  CAS  PubMed  Google Scholar 

  • Adriaenssens E., Lottin S., Berteaux N., Hornez L., Fauquette W., Fafeur V., Peyrat J.P., Le Bourhis X., Hondermarck H., Coll J., Dugimont T., Curgy J.J., 2002, Cross-talk between mesenchyme and epithelium increases H19 gene expression during scattering and morphogenesis of epithelial cells. Exp. Cell. Res. 275: 215–29.

    Article  CAS  PubMed  Google Scholar 

  • Anderson, N.L., Anderson, N.G., 2002, The human plasma proteome: history, character, and diagnostic prospects. Mol. Cell. Proteomics 1: 845–67.

    CAS  PubMed  Google Scholar 

  • Bhattacharya, B., Prasad, G.L., Valverius, E M., Salomon, D.S., and Cooper, H.L., 1990, Tropomyosins of human mammary epithelial cells: consistent defects of expression in mammary carcinoma cell lines. Cancer Res. 50: 2105–2112.

    CAS  PubMed  Google Scholar 

  • Blagoev B., Kratchmarova I., Ong S.E., Nielsen M., Foster L.J., Mann M., 2003, A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling. Nat Biotechnol. 21: 315–318.

    Article  CAS  PubMed  Google Scholar 

  • Brannan C.I., Dees E.C., Ingram R.S., Tilghman S.M., 1990, The product of the H19 gene may function as an RNA. Mol. Cell. Biol. 10: 28–36.

    CAS  PubMed  Google Scholar 

  • Celis J.E., Gromov P., 2003, Proteomics in translational cancer research: Toward an integrated approach. Cancer Cell 3: 9–15.

    Article  CAS  PubMed  Google Scholar 

  • Chiarenza A., Lazarovici P., Lempereur L., Cantarelle G., Bianchi A., Bernardini R., 2001, Tamoxifen inhibits nerve growth factor-induced proliferation of the human breast cancerous cell line. Cancer Res. 61: 3002–3008.

    CAS  PubMed  Google Scholar 

  • Ciocca D.R., Elledge R., 2000, Molecular markers for predicting response to tamoxifen in breast cancer patients. Endocrine 13: 1–10.

    Article  CAS  PubMed  Google Scholar 

  • Colomer R., Shamon L.A., Tsai M.S., Lupu R., 2001, Herceptin: from the bench to the clinic. Cancer Invest. 19: 49–56.

    Article  CAS  PubMed  Google Scholar 

  • Craven R.A., Banks R.E., 2001, Laser capture microdissection and proteomics: possibilities and limitation. Proteomics 1: 1200–4.

    Article  CAS  PubMed  Google Scholar 

  • Descamps S., Lebourhis X., Delehedde M., Boilly B., Hondermarck H., 1998, Nerve growth factor is mitogenic for cancerous but not normal human breast epithelial cells. J. Biol. Chem. 273: 16659–16662.

    Article  CAS  PubMed  Google Scholar 

  • Descamps S., Toillon R.A., Adriaenssens E., Pawlowski V., Cool S.M., Nurcombe V., Le Bourhis X., Boilly B., Peyrat J.P., Hondermarck H., 2001, Nerve growth factor stimulates proliferation and survival of human breast cancer cells through two distinct signaling pathways. J. Biol. Chem. 276: 17864–17870.

    Article  CAS  PubMed  Google Scholar 

  • Dollé L., El Yazidi-Belkoura I., Adriaenssens E., Nurcombe V., Hondermarck H., (2003), Nerve growth factor overexpression and autocrine loop in breast cancer cells. Oncogene 22: 5592–601.

    PubMed  Google Scholar 

  • El Yazidi-Belkoura I., Adriaenssens E., Dollé L., Descamps S., Hondermarck H., 2003, Tumor Necrosis Factor Receptor-Associated Death Domain Protein (TRADD) is Involved in the Neurotrophin Receptor (p75NTR)-Mediated Anti-Apoptotic Activity of Nerve Growth Factor in Breast Cancer Cells. J.Biol.Chem. 278: 16952–16956.

    Article  PubMed  Google Scholar 

  • Ethier S.P., 1995, Growth factor synthesis and human breast cancer progression. J. Natl. Cancer Inst. 87: 964–973.

    CAS  PubMed  Google Scholar 

  • Ferguson A.T., Evron E., Umbricht C.B., Pandita T.K., Chan T.A., Hermeking H., Marks J.R., Lambers A.R., Futreal P.A., Stampfer M.R. and Sukumar, S., 2000, High frequency of hypermethylation at the 14-3-3 sigma locus leads to gene silencing in breast cancer. Proc. Natl. Acad. Sci. USA 97: 6049–6054.

    CAS  PubMed  Google Scholar 

  • Franzen, B., Linder, S., Alaiya, A.A., Eriksson, E., Fujioka, K., Bergman, A.C., Jornvall, H., and Auer, G., 1997, Analysis of polypeptide expression in benign and malignant human breast lesions. Electrophoresis 18: 582–587.

    CAS  PubMed  Google Scholar 

  • Franzen, B., Linder, S., Alaiya, A.A., Eriksson, E., Uruy, K., Hirano, T., Okuzawa, K., and Auer, G., 1996, Analysis of polypeptide expression in benign and malignant human breast lesions: down-regulation of cytokeratins. Br. J. Cancer 74: 1632–1638.

    CAS  PubMed  Google Scholar 

  • Franzen, B., Linder, S., Okuzawa, K., Kato, H., and Auer, G., 1993, Non enzymatic extraction of cells from clinical tumor material for analysis of gene expression by two-dimensional polyacrylamide gel electrophoresis. Electrophoresis 14: 1045–1053.

    CAS  PubMed  Google Scholar 

  • Fu H., Subramanian R.R., and Masters S.C., 2000, 14-3-3 proteins: structure, function, and regulation. Annu. Rev. Pharmacol. Toxicol. 40: 617–647.

    Article  CAS  PubMed  Google Scholar 

  • Fung E.T., Thulasiraman V., Weinberger S.R., Dalmasso E.A., 2001, Protein biochips for differential profiling. Curr. Opin. Biotechnol. 12: 65–69.

    Article  CAS  PubMed  Google Scholar 

  • Gharbi S., Gaffney P., Yang A, Zvelebil M.J., Cramer R., Waterfield M.D., Timms J.F., 2002, Evaluation of two-dimensional differential gel electrophoresis for proteomic expression analysis of a model breast cancer cell system. Mol. Cell. Proteomics 1: 91–8.

    CAS  PubMed  Google Scholar 

  • Giometti C.S., Tollaksen S.L., Chubb C., Williams C., Huberman E., 1995, Analysis of proteins from human breast epithelial cells using two-dimensional gel electrophoresis. Electrophoresis 16: 1215–1224.

    Article  CAS  PubMed  Google Scholar 

  • Gygi S.P., Rist B., Gerber S.A., Turecek F., Gelb M.H., Aebersold R., 1999, Quantitative analysis of complex protein mixtures using isotope-coded affinity tags. Nat. Biotechnol. 17: 994–999.

    Article  CAS  PubMed  Google Scholar 

  • Haber D., 2000, Roads leading to breast cancer. N. Engl. J. Med. 343: 1566–1568.

    Article  CAS  PubMed  Google Scholar 

  • Hanash S., 2003, Disease proteomics. Nature 422: 226–232.

    Article  CAS  PubMed  Google Scholar 

  • Hinsby A.M., Olsen J.V., Bennett K.L., Mann M., 2003, Signaling initiated by overexpression of the fibroblast growth factor receptor-1 investigated by mass spectrometry. Mol. Cell. Proteomics 2: 29–36.

    CAS  PubMed  Google Scholar 

  • Hondermarck H., 2003, Breast cancer: when proteomics challenges biological complexity. Mol. Cell. Proteomics 2: 281–91.

    CAS  PubMed  Google Scholar 

  • Hondermarck H., Vercoutter-Edouart A.S., Revillion F., Lemoine J., El-Yazidi-Belkoura I., Nurcombe V., Peyrat J.P., 2001, Proteomics of breast cancer for marker discovery and signal pathway profiling. Proteomics 1: 1216–32.

    Article  CAS  PubMed  Google Scholar 

  • Hondermarck H., McLaughlin C.S., Patterson S.D., Bradshaw R.A., 1994, Early changes in protein synthesis induced by basic fibroblast growth factor, nerve growth factor, and epidermal growth factor in PC12 pheochromocytoma cells. Proc. Natl. Acad. Sci. U S A. 91: 9377–9381.

    CAS  PubMed  Google Scholar 

  • Issaq H.J., 2001, The role of separation science in proteomics research. Electrophoresis 22: 3629–3638.

    CAS  PubMed  Google Scholar 

  • Jain K.K., 2002, Post-genomic applications of lab-on-a-chip and microarrays. Trends Biotechnol. 20: 184–5.

    CAS  PubMed  Google Scholar 

  • Jolly C., Morimoto R.I., 2000, Role of the heat shock response and molecular chaperones in oncogenesis and cell death. J. Natl.CancerInst. 92: 1564–1572.

    CAS  Google Scholar 

  • LeBourhis X., Toillon R.A., Boilly B., Hondermarck H., 2000, Autocrine and paracrine growth inhibitors of breast cancer cells. Breast Cancer Res. Treat. 60: 251–258.

    Article  CAS  PubMed  Google Scholar 

  • Li J, Zhang Z, Rosenzweig J, Wang YY, Chan DW., 2002, Proteomics and bioinformatics approaches for identification of serum biomarkers to detect breast cancer. Clin. Chem. 48: 1296–304.

    CAS  PubMed  Google Scholar 

  • Lottin S., Adriaenssens E., Dupressoir T., Berteaux N., Montpellier C., Coll J., Dugimont T., Curgy J.J., 2002, Overexpression of an ectopic H19 gene enhances the tumorigenic properties of breast cancer cells. Carcinogenesis 23: 1885–1895.

    Article  CAS  PubMed  Google Scholar 

  • Lottin S., Vercoutter-Edouart A.S., Adriaenssens E., Czeszak X., Lemoine J., Roudbaraki M., Coll J., Hondermarck H., Dugimont T., Curgy J.J., 2002, Thioredoxin post-transcriptional regulation by H19 provides a new function to mRNA-like non-coding RNA. Oncogene 21: 1625–31.

    Article  CAS  PubMed  Google Scholar 

  • Maloney T.M., Paine P.L., Russo J., 1989, Polypeptide composition of normal and neoplastic human breast tissues and cells analyzed by two-dimensional gel electrophoresis. Breast Cancer Res. Treat. 14: 337–348.

    Article  CAS  PubMed  Google Scholar 

  • Nakamura H., Nakamura K., Yodoi J., 1997, Redox regulation of cellular activation. Annu. Rev. Immunol. 15: 351–69.

    Article  CAS  PubMed  Google Scholar 

  • Nelson R.W., Nedelkov D., Tubbs K.A., 2000, Biosensor chip mass spectrometry: a chipbased proteomics approach. Electrophoresis 21: 1155–63.

    CAS  PubMed  Google Scholar 

  • Nurcombe V., Smart C.E., Chipperfield H., Cool S.M., Boilly B., Hondermarck, H., 2000, The proliferative and migratory activities of breast cancer cells can be differentially regulated by heparan sulfates. J. Biol. Chem. 275: 30009–30018.

    Article  CAS  PubMed  Google Scholar 

  • Page M.J., Amess B., Townsend R.R., Parekh R., Herath A., Brusten L., Zvelebil M.J., Stein R.C., Waterfield M.D., Davies S.C., and O’Hare M.J., 1999, Proteomic definition of normal human luminal and myoepithelial breast cells purified from reduction mammoplasties. Proc. Natl. Acad. Sci. U S A 96: 12589–12594.

    Article  CAS  PubMed  Google Scholar 

  • Pandey A., Podtelejnikov A.V., Blagoev B., Bustelo X.R., Mann M., Lodish H.F., 2000, Analysis of receptor signaling pathways by mass spectrometry: identification of vav-2 as a substrate of the epidermal and platelet-derived growth factor receptors. Proc. Natl. Acad. Sci. U S A 97: 179–184.

    Article  CAS  PubMed  Google Scholar 

  • Pearl L.H., Prodromou C., 2000, Structure and in vivo function of HSP90. Curr. Opin. Struct. Biol. 10: 46–51.

    Article  CAS  PubMed  Google Scholar 

  • Piek E., Roberts A.B., 2001, Suppressor and oncogenic roles of transforming growth factorbeta and its signaling pathways in tumorigenesis. Adv. Cancer Res. 83: 1–54.

    CAS  PubMed  Google Scholar 

  • Rahmoune H., Chen H.L, Gallagher J.T., Rudland P.S., Fernig D.G., 1998, Interaction of heparan sulfate from mammary gland cells with acid fibroblast growth factor and basic FGF. Regulation of the activity of bFGF by high and low affinity binding sites in heparan sulfate. J. Biol. Chem. 273: 7303–7310.

    Article  CAS  PubMed  Google Scholar 

  • Schrohl A.S., Pedersen A.N., Jensen V., Mouridsen H., Murphy G., Foekens J.A., Brunner N., Holten-Andersen M.N., 2003, Tumour tissue concentrations of the proteinase inhibitors TIMP-1 and PAI-1 are complementary in determining prognosis in primary breast cancer. Mol. Cell. Proteomics 3: 164–72.

    Google Scholar 

  • Soskic V., Gorlach M., Poznanovic S., Boehmer F.D., Godovac-Zimmermann J., 1999, Functional proteomics analysis of signal transduction pathways of the platelet-derived growth factor beta receptor. Biochemistry 38: 1757–1764.

    Article  CAS  PubMed  Google Scholar 

  • Stastny J., Prasad R., Fosslien E., 1984, Tissue proteins in breast cancer, as studied by use of two-dimensional electrophoresis. Breast Cancer Res. Treat. 30: 1914–1918.

    CAS  Google Scholar 

  • Tagliabue E., Castiglioni F., Ghirelli C., Modugno M., Asnaghi L., Melani C., Menard S., 2000, Nerve growth factor cooperates with p185HER-2 in activating growth of human breast carcinoma cells. J. Biol. Chem. 275: 5388–5394.

    Article  CAS  PubMed  Google Scholar 

  • Trask D.K., Band V., Zajchowski D.A., Yaswen P., Suh T., Sager. R., 1990, Keratins as markers that distinguish normal and tumor-derived mammary epithelial cells. Proc. Natl. Acad. Sci. U S A. 87: 2319–2323.

    CAS  PubMed  Google Scholar 

  • Umbricht C.B., Evron E., Gabrielson E., Ferguson A., Marks J., Sukumar S., 2001, Hypermethylation of 14-3-3 sigma (stratifin) is an early event in breast cancer. Oncogene 20: 3348–53.

    Article  CAS  PubMed  Google Scholar 

  • Vejda S, Posovszky C, Zelzer S, Peter B, Bayer E, Gelbmann D, Schulte-Hermann R, Gerner C., 2002, Plasma from cancer patients featuring a characteristic protein composition mediates protection against apoptosis. Mol.Cell.Proteomics 1: 387–93.

    CAS  PubMed  Google Scholar 

  • Vercoutter-Edouart A.S., Czeszak X., Crepin M., Lemoine J., Boilly B., Le Bourhis X., Peyrat J.P., Hondermarck H., 2001, Proteomic detection of changes in protein synthesis induced by fibroblast growth factor-2 in MCF-7 human breast cancer cells. Exp. Cell Res. 262: 59–68.

    Article  CAS  PubMed  Google Scholar 

  • Vercoutter-Edouart A.S., Lemoine J., Le Bourhis X., Hornez L., Boilly B., Nurcombe V., Revillion F., Peyrat J.P. and Hondermarck H., 2001, Proteomic analysis reveals that 14-3-3 sigma is down-regulated in human breast cancer cells. Cancer Res. 61: 76–80.

    CAS  PubMed  Google Scholar 

  • Vercoutter-Edouart A.S., Lemoine J., Smart C.E., Nurcombe V., Boilly B., Peyrat J.P., Hondermarck H., 2000, The mitogenic signaling pathway for fibroblast growth factor-2 involves the tyrosine phosphorylation of cyclin D2 in MCF-7 human breast cancer cells. FEBS Lett. 478: 209–215.

    Article  CAS  PubMed  Google Scholar 

  • Weinberger S.R., Morris T.S., Pawlak M., 2000, Recent trends in protein biochip technology. Pharmacogenomics 1: 395–416.

    Article  CAS  PubMed  Google Scholar 

  • Westley B. and Rochefort H., 1980, A secreted glycoprotein induced by estrogen in human breast cancer cell lines. Cell 20: 353–362.

    Article  CAS  PubMed  Google Scholar 

  • Westley B. and Rochefort H., 1980, A secreted glycoprotein induced by estrogen in human breast cancer cell lines. Cell 20: 353–362.

    Article  CAS  PubMed  Google Scholar 

  • Wirth P.J., Egilsson V., Gudnason V., Ingvarsson S., Thorgeirsson S.S., 1987, Specific polypeptide differences in normal versus malignant human breast tissues by twodimensional electrophoresis. Breast Cancer Res. Treat. 10: 177–189.

    Article  CAS  PubMed  Google Scholar 

  • Wirth P.J., 1989, Specific polypeptide differences in normal versus malignant breast tissue by two-dimensional electrophoresis. Electrophoresis 10: 543–54.

    Article  CAS  PubMed  Google Scholar 

  • Worland P.J., Bronzert D., Dickson R.B., Lippman M.E., Hampton L., Thorgeirsson S.S., Wirth. P.J., 1989, Secreted and cellular polypeptide patterns of MCF-7 human breast cancer cells following either estrogen stimulation or v-H-ras transfection. Cancer Res. 49: 51–57.

    CAS  PubMed  Google Scholar 

  • Wright G.L., 1974, Two-dimensional acrylamide gel electrophoresis of cancer-patient serum proteins. Annu. Clin. Lab. Sci. 4: 281–293.

    CAS  Google Scholar 

  • Wulfkuhle JD, Sgroi DC, Krutzsch H, McLean K, McGarvey K, Knowlton M, Chen S, Shu H, Sahin A, Kurek R, Wallwiener D, Merino MJ, Petricoin EF 3rd, Zhao Y, Steeg PS., 2002, Proteomics of human breast ductal carcinoma in situ. Cancer Res. 62: 6740–9.

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. INSERM-ESPRI, University of Sciences and Technologies Lille, Villeneuve ďAscq, France

    Franck Vandermoere, Ikram El Yazidi-Belkoura, Eric Adriaenssens & Hubert Hondermarck

  2. UMR-8576, IFR-118, University of Sciences and Technologies Lille, Villeneuve ďAscq, France

    Jerome Lemoine

Authors
  1. Franck Vandermoere
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ikram El Yazidi-Belkoura
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Eric Adriaenssens
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Jerome Lemoine
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Hubert Hondermarck
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. University of Sciences and Technologies, Lille, France

    Hubert Hondermarck

Rights and permissions

Reprints and permissions

Copyright information

© 2004 Kluwer Academic Publishers

About this chapter

Cite this chapter

Vandermoere, F., El Yazidi-Belkoura, I., Adriaenssens, E., Lemoine, J., Hondermarck, H. (2004). Proteomics in Oncology: the Breast Cancer Experience. In: Hondermarck, H. (eds) Proteomics: Biomedical and Pharmaceutical Applications. Springer, Dordrecht. https://doi.org/10.1007/1-4020-2323-5_6

Download citation

  • DOI: https://doi.org/10.1007/1-4020-2323-5_6

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-1-4020-2322-4

  • Online ISBN: 978-1-4020-2323-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation