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The Immunoproteome of H. pylori

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Proteomics: Biomedical and Pharmaceutical Applications

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Conclusions

The analysis of the immunoproteome of H. pylori has already lead to the identification of candidate molecules for vaccine development and of putative diagnostic value. Only 10% of the 600 immunogenic molecules are currently identified. The near future will see this number growing rapidly and is likely to lead to the identification of more useful candidates. From a basic science point of view, the cumulative data will yield insight into general properties of the immune system with regard to its detection threshold when confronted with a microbial pathogen of similar complexity. This information will be valuable for improving current algorithms e.g. for vaccine candidate selection. Technical advances will extend the analysis to the study of conformational epitopes and protein chip technologies may be used to compile the H. pylori species proteome. We anticipate that our understanding of the immunoproteome will help to reduce the complexity of such protein arrays while keeping their likely power for the development of new diagnostic tools.

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Authors and Affiliations

  1. Department of Molecular Biology, Max-Planck-Institute for Infection Biology, Schumannstrasse 21/22, D-10117, Berlin, Germany

    Toni Aebischer, Alexander Krah, Dirk Bumann & Thomas F. Meyer

  2. Proteomics Unit, Max-Planck-Institute for Infection Biology, Schumannstrasse 21/22, D-10117, Berlin, Germany

    Alexander Krah & Peter R. Jungblut

Authors
  1. Toni Aebischer
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  2. Alexander Krah
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  3. Dirk Bumann
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  4. Peter R. Jungblut
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  5. Thomas F. Meyer
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Editors and Affiliations

  1. University of Sciences and Technologies, Lille, France

    Hubert Hondermarck

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© 2004 Kluwer Academic Publishers

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Aebischer, T., Krah, A., Bumann, D., Jungblut, P.R., Meyer, T.F. (2004). The Immunoproteome of H. pylori . In: Hondermarck, H. (eds) Proteomics: Biomedical and Pharmaceutical Applications. Springer, Dordrecht. https://doi.org/10.1007/1-4020-2323-5_13

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  • DOI: https://doi.org/10.1007/1-4020-2323-5_13

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-1-4020-2322-4

  • Online ISBN: 978-1-4020-2323-1

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