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The IGF-1 Receptor in Cell Survival: Signalling and Regulation

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Cell Engineering

Part of the book series: Cell Engineering ((CEEN,volume 4))

Summary

The suppression of apoptosis by the IGF system is critical for normal cell development, proliferation, differentiation and motility. Aberrations in IGF signalling mechanisms contribute to cell transformation, tumour progression and metastasis. Many questions remain to be answered as to how exactly the IGF system mediates its effects both in normal and tumour cells and how the IGF-1R interacting proteins and downstream signalling cascades are regulated. The importance of the IGF system is underscored by the significant interest in the development of anti-IGF therapies for IGF sensitive cancers. Future developments in cancer therapy are likely to focus on methods to target these therapies to diseased but not normal cells.

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  1. Cell Biology Laboratory, Department of Biochemistry, BioSciences Institute, University College Cork, Cork, Ireland

    Patrick A. Kiely, Denise M. O’Gorman, Anthony Lyons & Rosemary O’Connor

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  1. School of Chemical Engineering, The University of Birmingham, Edgbaston, Birmingham, UK

    Mohamed Al-Rubeai

  2. Swiss Federal Institute of Technology, Zurich, Switzerland

    Martin Fussenegger

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Kiely, P.A., O’Gorman, D.M., Lyons, A., O’Connor, R. (2004). The IGF-1 Receptor in Cell Survival: Signalling and Regulation. In: Al-Rubeai, M., Fussenegger, M. (eds) Cell Engineering. Cell Engineering, vol 4. Springer, Dordrecht. https://doi.org/10.1007/1-4020-2217-4_3

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