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The Molecular Pathogenesis of Human Papillomavirus-Associated Cancer

  • Stephen T. Oh
  • Laimonis A. Laimins
Chapter
Part of the Cancer Prevention — Cancer Causes book series (CPCC, volume 2)

Abstract

Human papillomaviruses (HPVs) are small, non-enveloped, double-stranded DNA viruses that induce hyperproliferative lesions in epithelial tissues (Howley, 1996). More than 100 different types of HPV have been identified and each of these exhibits greater than 10% difference at the nucleotide level in the LI capsid coding sequence (Meyers et al., 1996; zur Hausen, 2002). These HPV types infect a range of epithelial tissues. For instance, HPV 1 infects epithelial tissues on the soles of feet while HPV types 2, 4 and 7 infect cutaneous epithelia to induce common hand warts. The most well characterized HPV types, however, are those that infect genital epithelia, and these can be sub-grouped based on their association with cervical and other anogenital cancers. “High-risk” HPV types such as HPV 16, 18, 31, and 45 induce lesions that can lead to cancer, while “low-risk” types such as HPV 6 and 11 induce benign lesions that rarely progress (zur Hausen, 2002; Howley, 1996).

Keywords

Viral Life Cycle hTERT Expression Upstream Regulatory Region Human Foreskin Keratinocytes CCAAT Displacement Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media Dordrecht 2004

Authors and Affiliations

  • Stephen T. Oh
    • 1
  • Laimonis A. Laimins
    • 1
  1. 1.Department of Microbiology - Immunology, Feinberg School of MedicineNorthwestern UniversityUSA

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