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Transcriptional Control of Proteases

  • H. Allgayer
  • E. Lengyel
  • D. D. Boyd
Part of the Cancer Metastasis — Biology and Treatment book series (CMBT, volume 4)

Conclusions

We now have a good knowledge of the trans -acting factors and cis elements involved in the regulation of protease expression in cancer. However, there are still issues which remain unanswered. For example, in many cancers, protease expression is not in the tumor cells but in the surrounding stromal cells. How then can this be explained if a variety of trans acting factors such as AP-1, NF-κB are constitutively active in the cancer cells. Future studies will have to address this question. It may very well be that the chromatin environment and epigenetic factors, such as methylation shown to regulate urokinase expression (Xing and Rabbani, 1999), play a crucial role in the regulation of gene expression and works in concert with the know trans acting factors to exert control of gene expression.

Keywords

Transcription Factor Binding Site Phorbol Ester Protease Gene Protease Expression Transcription Factor Family Member 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Kluwer Academic Publishers 2002

Authors and Affiliations

  • H. Allgayer
    • 1
  • E. Lengyel
    • 2
  • D. D. Boyd
    • 3
  1. 1.Department SurgeryKlinikum Grosshadern Ludwig-Maximilians UniversityMunichGermany
  2. 2.Department of Obstetrics and GynecologyTechnical University of MunichMunichGermany
  3. 3.Department of Cancer BiologyM.D. Anderson Cancer CenterHoustonUSA

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