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Hepatitis Delta Virus pp 81–92Cite as

Diagnosis of Hepatitis D Virus Infection

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Part of the Medical Intelligence Unit book series (MIUN)

Abstract

Hepatitis D virus (HDV) is a small defective virus with a single stranded circular RNA of 1.7 kb in size1-3. Its hepatitis B surface antigen (HBsAg) envelope is provided by the helper hepatitis B virus (HBV) for successfiil package and transmission of HDV4,5. The antigenomic strand of HDV encodes a single protein, hepatitis delta antigen (HDAg) of two molecular weight forms. The large form HDAg with a 19-amino acid extension at the C-terminus plays a key role in the package of HDV and suppresses viral replication in a trans-dominant negative manner, while the small form plays an essential role in trans-activating the replication of HDV RNA.2,3

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Authors and Affiliations

  1. Division of Gastroenterology, Taipei Veterans General Hospital, Insitute of Clinical Medicine, National Yang-ming University, 201 Shih-Pai Road, Sec. 2, Taipei, 112, Taiwan

    Jaw-Ching Wu

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  1. Jaw-Ching Wu
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© 2006 Landes Bioscience and Springer Science+Business Media

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Wu, JC. (2006). Diagnosis of Hepatitis D Virus Infection. In: Hepatitis Delta Virus. Medical Intelligence Unit. Springer, Boston, MA. https://doi.org/10.1007/0-387-35103-5_8

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