Diagnosis of Hepatitis D Virus Infection

  • Jaw-Ching Wu
Part of the Medical Intelligence Unit book series (MIUN)


Hepatitis D virus (HDV) is a small defective virus with a single stranded circular RNA of 1.7 kb in size1-3. Its hepatitis B surface antigen (HBsAg) envelope is provided by the helper hepatitis B virus (HBV) for successfiil package and transmission of HDV4,5. The antigenomic strand of HDV encodes a single protein, hepatitis delta antigen (HDAg) of two molecular weight forms. The large form HDAg with a 19-amino acid extension at the C-terminus plays a key role in the package of HDV and suppresses viral replication in a trans-dominant negative manner, while the small form plays an essential role in trans-activating the replication of HDV RNA.2,3


Reverse Transcription Polymerase Chain Reaction Hepatitis Delta Virus Restriction Fragment Length Poly Hepatitis Delta Virus Infection Delta Antigen 
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Copyright information

© Landes Bioscience and Springer Science+Business Media 2006

Authors and Affiliations

  • Jaw-Ching Wu
    • 1
  1. 1.Division of Gastroenterology, Taipei Veterans General Hospital, Insitute of Clinical MedicineNational Yang-ming UniversityTaipeiTaiwan

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