Abstract
Replication and transcription of HDV proceed via RNA-dependent RNA synthesis. These reactions are thought to be catalyzed at least in part by host RNA polymerase II (RNAPII). Hepatitis delta antigen (HDAg), which is critical for these processes, was recently proposed to function as a transcription elongation factor for RNAPII. The involvement of a DNA-dependent RNA polymerase in RNA-dependent RNA synthesis is itself intriguing and poses fundamental questions as to how RNA synthesis initiates, elongates, and terminates on an unusual HDV RNA template. In addition, the presence of a ‘Viral’ transcription elongation factor is unprecedented in eukaryotes, whereas a few are known to exist in prokaryotes. Thus, the study of HDV replication and transcription should provide tremendous insight into the basic mechanism underlying RNAPII transcription.
Keywords
- Hepatitis Delta Virus
- Transcription Elongation
- Nascent Transcript
- Transcription Elongation Factor
- Positive Transcription Elongation Factor
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References
Fels A, Hu K, Riesner D. Transcription of potato spindle tuber viroid by RNA polymerase II starts predominantly at two specific sites. Nucleic Acids Res 2001; 29:4589–4597.
Beard MR, MacNaughton TB, Gowans EJ. Identification and characterization of a hepatitis delta virus RNA transcriptional promoter. J Virol 1996; 70:4986–4995.
Filipovska J, Konarska MM. Specific HDV RNA-templated transcription by pol II in vitro. RNA 2000; 6:41–54.
Gudima S, Wu SY, Chiang CM et al. Origin of hepatitis delta virus mRNA. J Virol 2000; 74:7204–7210.
Yamaguchi Y, Filipovska J, Yano K et al. Stimulation of RNA polymerase II elongation by hepatitis delta antigen. Science 2001; 293:124–127.
Nedialkov YA, Gong XQ, Hovde SL et al. NTP-driven translocation by human RNA polymerase II. J Biol Chem 2003; 278:18303–18312.
Zhang C, Yan H, Burton ZF. Combinatorial control of human RNA polymerase II pausing and transcript cleavage by Transcription Factor IIF, hepatitis delta antigen and TFIIS/SII. J Biol Chem 2003; 278(50):50101–11.
MacNaughton TB, Gowans EJ, McNamara SP et al. Hepatitis delta antigen is necessary for access of hepatitis delta virus RNA to the cell transcriptional machinery but is not part of the transcriptional complex. Virology 1991; 184:387–390.
Moraleda G, Taylor J. Host RNA polymerase requirements for transcription of the human hepatitis delta virus genome. J Virol 2001; 75:10161–10169.
Modahl LE, Macnaughton TB, Zhu N et al. RNA-Dependent replication and transcription of hepatitis delta virus RNA involve distinct cellular RNA polymerases. Mol Cell Biol 2000; 20:6030–6039.
Macnaughton TB, Shi ST, Modahl LE et al. Rolling circle replication of hepatitis delta virus RNA is carried out by two different cellular RNA polymerases. J Virol 2002; 76:3920–3927.
Fiedler U, Marc Timmers HT. Peeling by binding or twisting by cranking: Models for promoter opening and transcription initiation by RNA polymerase II. Bioessays 2000; 22:316–326.
Dvir A. Promoter escape by RNA polymerase II. Biochim Biophys Acta 2002; 1577:208–223.
Gnatt A. Elongation by RNA polymerase II: Structurefunction relationship. Biochim Biophys Acta 2002; 1577:175–190.
Proudfoot NJ, Furger A, Dye MJ. Integrating mRNA processing with transcription. Cell 2002; 108:501–12.
Pan G, Greenblatt J. Initiation of transcription by RNA polymerase II is limited by melting of the promoter DNA in the region immediately upstream of the initiation site. J Biol Chem 1994; 269:30101–30104.
Kadesch TR, Chamberlin MJ. Studies of in vitro transcription by calf thymus RNA polymerase II using a novel duplex DNA template. J Biol Chem 1982; 257:5286–5295.
Tornaletti S, Donahue BA, Reines D et al. Nucleotide sequence context effect of a cyclobutane pyrimidine dimer upon RNA polymerase II transcription. J Biol Chem 1997; 272:31719–31724.
Kuraoka I, Endou M, Yamaguchi Y et al. Effects of endogenous DNA base lesions on transcription elongation by mammalian RNA polymerase II. Implications for transcription-coupled DNA repair and transcriptional mutagenesis. J Biol Chem 2003; 278:7294–7299.
Conaway JW, Shilatifard A, Dvir A et al. Control of elongation by RNA polymerase II. Trends Biochem Sci 2000; 25:375–380.
Yamaguchi Y, Takagi T, Wada T et al. NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongation. Cell 1999; 97:41–51.
Kim JB, Sharp PA. Positive transcription elongation factor B phosphorylates hSPT5 and RNA polymerase II carboxyl-terminal domain independently of cyclin-dependent kinase-activating kinase. J Biol Chem 2001; 276:12317–12323.
Wu CH, Yamaguchi Y, Benjamin LR et al. NELF and DSIF cause promoter proximal pausing on the hsp70 promoter in Drosophila. Genes Dev 2003; 17:1402–1414.
Narita T, Yamaguchi Y, Yano K et al. Human transcription elongation factor NELF: Identification of novel subunits and reconstitution of the functionally active complex. Mol Cell Biol 2003; 23:1863–1873.
Glenn JS, Watson JA, Havel CM et al. Identification of a prenylation site in delta virus large antigen. Science 1992; 256:1331–1333.
Cramer P, Bushnell DA, Kornberg RD. Structural basis of transcription: RNA polymerase II at 2.8 angstrom resolution. Science 2001; 292:1863–1876.
Gnatt AL, Cramer P, Fu J et al. Structural basis of transcription: An RNA polymerase II elongation complex at 3.3 A resolution. Science 2001; 292:1876–1882.
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© 2006 Landes Bioscience and Springer Science+Business Media
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Yamaguchi, Y., Handa, H. (2006). Hepatitis Delta Antigen and RNA Polymerase II. In: Hepatitis Delta Virus. Medical Intelligence Unit. Springer, Boston, MA. https://doi.org/10.1007/0-387-35103-5_6
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DOI: https://doi.org/10.1007/0-387-35103-5_6
Publisher Name: Springer, Boston, MA
Print ISBN: 978-0-387-32230-8
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