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Genotype of Hepatitis Delta Virus

  • Nobuyuki Enomoto
  • Hideki Watanabe
  • Kazuyoshi Nagayama
  • Tsuyoshi Yamashiro
  • Mamoru Watanabe
Part of the Medical Intelligence Unit book series (MIUN)

Abstract

Hepatitis delta virus (HDV) is a defective virus that requires hepatitis B virus (HBV) surface antigen for virion assembly and infection,1 and contains a negative single stranded circular RNA genome of 1.7 kilobases.2,3 HDV is classified into three geno-types (genotype I, II and III) based on genetic sequence analysis (Fig. 1).4 Genotype II shows approximately 75% homology to genotype I, and genotype III shares about 60 to 65% homol-ogy with genotype I and II. There are many variants within each genotype. Especially, HDV genotype II is further divided into two types (i.e., Ila and lib), with 77% nucleotide homology between the complete sequences of genotype Ila and lib.5 The nucleotide homology between genotype lib and Ilb-M, the newly identified lib variant, is 88–90%.6 Similarly, Ila variant was recently found in Siberia (Ila-Yakutia), which in comparison with Ila shows a similar degree of genetic differences.7 These genotypes show different geographical distributions and clinical pictures, which is thought to be caused by functional differences of genotype-specific sequences of HDV-RNA as well as HDAg protein.

Keywords

Hepatitis Delta Virus Chromosome Region Maintenance Versus Genotype Packaging Signal Hepatitis Delta Virus Infection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Landes Bioscience and Springer Science+Business Media 2006

Authors and Affiliations

  • Nobuyuki Enomoto
    • 1
  • Hideki Watanabe
    • 2
  • Kazuyoshi Nagayama
    • 2
  • Tsuyoshi Yamashiro
    • 3
  • Mamoru Watanabe
    • 2
  1. 1.First Department of Internal MedicineUniversity of YamanashiTamaho, YamanashiJapan
  2. 2.Department of Gastroenterology and HepatologyTokyo Medical and Dental UniversityTokyoJapan
  3. 3.First Department of Internal MedicineUniversity of RyukyusOkinawaJapan

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