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Transfusion as a Risk Factor for ALI and ARDS

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Intensive Care Medicine
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Abstract

Transfusions are regularly employed in the care of the critically ill. While the transmission of infectious agents and clerical errors have long been major concerns, a more common non-infectious complication of transfusion, namely acute lung injury/acute respiratory distress syndrome (ALI/ARDS), has been neglected. Indeed, during the past several years, post-transfusion ALI/ARDS (transfusion-related acute lung injury — TRALI) has become the leading cause of transfusion-related death in the United States [1]. It likely occurs much more frequently than previously estimated. With skyrocketing health care costs and the continuous emphasis on improvement in patient care, it is of paramount importance to better define this transfusion-related phenomenon and to design effective strategies for its prevention. Several investigator groups have been on the leading edge in the quest to clearly elucidate this disease entity and define its prevalence.

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References

  1. Toy P, Popovsky MA, Abraham E, et al (2005) Transfusion-related acute lung injury: definition and review. Crit Care Med 33:721–726

    Article  PubMed  Google Scholar 

  2. Popovsky MA, Moore SB (1985) Diagnostic and pathogenetic considerations in transfusion-related acute lung injury. Transfusion 25:573–577

    Article  PubMed  CAS  Google Scholar 

  3. Kleinman S, Caulfield T, Chan P, et al (2004) Toward an understanding of transfusion-related acute lung injury: statement of a consensus panel. Transfusion 44:1774–1789

    Article  PubMed  Google Scholar 

  4. Kopko PM, Marshall CS, MacKenzie MR, Holland PV, Popovsky MA (2002) Transfusion-related acute lung injury: Report of a clinical look-back investigation. JAMA 287:1968–1971

    Article  PubMed  Google Scholar 

  5. Pepe PE, Potkin RT, Reus DH, Hudson LD, Carrico CJ (1982) Clinical predictors of the adult respiratory distress syndrome. Am J Surg 144:124–130

    Article  PubMed  CAS  Google Scholar 

  6. Hudson LD, Milberg JA, Anardi D, Maunder RJ (1995) Clinical risks for development of the acute respiratory distress syndrome. Am J Respir Crit Care Med 151:293–301

    PubMed  CAS  Google Scholar 

  7. Gong MN, Wei Z, Xu LL, Miller DP, Thompson BT, Christiani DC (2004) Polymorphism in the surfactant protein-B gene, gender, and the risk of direct pulmonary injury and ARDS. Chest 125:203–211

    Article  PubMed  CAS  Google Scholar 

  8. Gong MN, Thompson BT, Williams P, Pothier L, Boyce PD, Christiani DC (2005) Clinical predictors of and mortality in acute respiratory distress syndrome: potential role of red cell transfusion. Crit Care Med 33:1191–1198

    Article  PubMed  Google Scholar 

  9. Gajic O, Dara SI, Mendez JL, et al (2004) Ventilator-associated lung injury in patients without acute lung injury at the onset of mechanical ventilation. Crit Care Med 32:1817–1824

    Article  PubMed  Google Scholar 

  10. Gajic O, Rana R, Mendez JL, et al (2004) Acute lung injury after blood transfusion in mechanically ventilated patients. Transfusion 44:1468–1474

    Article  PubMed  Google Scholar 

  11. Holness L, Knippen MA, Simmons L, Lachenbruch PA (2004) Fatalities caused by TRALI. Transfus Med Rev 18:184–188

    Article  PubMed  Google Scholar 

  12. Croce MA, Tolley EA, Claridge JA, Fabian TC (2005) Transfusions result in pulmonary morbidity and death after a moderate degree of injury. J Trauma 59:19–23

    PubMed  Google Scholar 

  13. Hebert PC, Wells G, Blajchman MA, et al (1999) A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. Transfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials Group. N Engl J Med 340:409–417

    Article  PubMed  CAS  Google Scholar 

  14. Silliman CC, Voelkel NF, Allard JD, et al (1998) Plasma and lipids from stored packed red blood cells cause acute lung injury in an animal model. J Clin Invest 101:1458–1467

    Article  PubMed  CAS  Google Scholar 

  15. Seeger W, Schneider U, Kreusler B, et al (1990) Reproduction of transfusion-related acute lung injury in an ex vivo lung model. Blood 76:1438–1444

    PubMed  CAS  Google Scholar 

  16. Sachs UJ, Hattar K, Weissmann N, et al (2005) Antibody-induced neutrophil activation as a trigger for transfusion-related acute lung injury in an ex vivo rat lung model. Blood: Oct 6 (Epub ahead of print)

    Google Scholar 

  17. Silliman CC, Ambruso DR, Boshkov LK (2004) Transfusion-related acute lung Injury (TRALI). Blood 2266–2273

    Google Scholar 

  18. Palfi M, Berg S, Ernerudh J, Berlin G (2001) A randomized controlled trial of transfusion-related acute lung injury: is plasma from multiparous blood donors dangerous? Transfusion 41:317–322

    Article  PubMed  CAS  Google Scholar 

  19. Insunza A, Romon I, Gonzalez-Ponte M, et al (2004) Implementation of a strategy to prevent TRALI in a regional blood centre. Transfus Med 14:157–164

    Article  PubMed  CAS  Google Scholar 

  20. Bray RA, Harris SB, Josephson CD, Hillyer CD, Gebel HM (2004) Unappreciated risk factors for transplant patients: HLA antibodies in blood components. Hum Immunol 65:240–244

    Article  PubMed  CAS  Google Scholar 

  21. Silliman CC, Boshkov LK, Mehdizadehkashi Z, et al (2003) Transfusion-related acute lung injury: epidemiology and a prospective analysis of etiologic factors. Blood 101:454–462

    Article  PubMed  CAS  Google Scholar 

  22. Reiter CD, Wang X, Tanus-Santos JE, et al (2002) Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease. Nat Med 8:1383–1389

    Article  PubMed  CAS  Google Scholar 

  23. Bernard GR, Artigas A, Brigham KL, et al (1994) The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination. Am J Respir Crit Care Med 149:818–824

    PubMed  CAS  Google Scholar 

  24. Gajic O, Moore SB (2005) Transfusion-related acute lung injury. Majo Clin Proc 80:766–770

    CAS  Google Scholar 

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Belsher, J., Khan, H., Gajic, O. (2006). Transfusion as a Risk Factor for ALI and ARDS. In: Vincent, JL. (eds) Intensive Care Medicine. Springer, New York, NY. https://doi.org/10.1007/0-387-35096-9_27

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  • DOI: https://doi.org/10.1007/0-387-35096-9_27

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-30156-3

  • Online ISBN: 978-0-387-35096-7

  • eBook Packages: MedicineMedicine (R0)

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