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The Vascular Bed during Critical Illness: Evaluation in Animal Models

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Intensive Care Medicine

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Abstract

Vascular reactivity has a fundamental role in regulating blood flow and tissue oxygen consumption. Vascular tone is regulated by receptors in endothelial and smooth muscle cells which can be stimulated by biochemical signals or a physical stimulus [1]. Receptor abundance and their response to stimuli is different among the different vascular beds, which enables fine tuning between organ perfusion and oxygen consumption according to different metabolic needs [1]. Vascular reactivity contributes to maintain the adequacy of tissue perfusion in response to acute injury such as sepsis and trauma [2]. This compensatory response can redirect regional blood flow towards organs where a decrease in oxygen consumption would have detrimental consequences for the organism such as the brain and the coronary arteries [3].

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Author information

Authors and Affiliations

  1. Department of Intensive Care Medicine, University Hospital Inselspital, 3010, Bern, Switzerland

    J. Gorrasi, J. Takala & S. M. Jakob

Authors
  1. J. Gorrasi
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  2. J. Takala
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  3. S. M. Jakob
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Editor information

Editors and Affiliations

  1. Department of Intensive Care Erasme Hospital, Free University of Brussels, Route de Lennik 808, 1070, Brussels, Belgium

    Jean-Louis Vincent MD, PhD, FCCM, FCCP (Head) (Head)

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© 2006 Springer Science + Business Media Inc.

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Gorrasi, J., Takala, J., Jakob, S.M. (2006). The Vascular Bed during Critical Illness: Evaluation in Animal Models. In: Vincent, JL. (eds) Intensive Care Medicine. Springer, New York, NY. https://doi.org/10.1007/0-387-35096-9_12

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  • DOI: https://doi.org/10.1007/0-387-35096-9_12

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-30156-3

  • Online ISBN: 978-0-387-35096-7

  • eBook Packages: MedicineMedicine (R0)

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