4.5.4. Concluding remarks
Here we demonstrated that aloesin, a chromone derivative, is the ingredient responsible for the cell growth stimulating effect of aloe vera, which has been used for several thousand years as a folk medicine for wound healing and skin regeneration. Moreover, the cell-growth stimulatory effect of aloesin and its derivative is associated with the inductions of cyclin E-dependent kinase components and its positive regulator, cdc25A. An increased level of these proteins activates cyclin E/cdk2 kinase activity and promotes DNA synthesis of cells. This study provides the first experimental evidence showing that the aloesin present in Aloe vera exerts a mammalian cell-growth stimulatory effect by inducing cell cycle regulator proteins. Therefore, we propose that aloe vera is an important herb medicine with a useful clinical application to wound healing and skin or tissue regeneration.
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