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Fas-Activation, Development and Homeostasis of T Cells

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Fas Signaling

Part of the book series: Medical Intelligence Unit ((MIUN))

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Abstract

Fas (APO-1/CD95) is found on various cells of the immune system where its expression depends on differentiation and activation status of the cells. Analysis of the function of Fas on T lymphocytes has been the objective of many studies. Like in most cells carrying Fas, ligation by antibodies or FasL can induce apoptosis in T cells. Over the years, Fas has been implicated in the regulation of many aspects of T cell physiology. However, more recent data have challenged some of the earlier views, and the matter of the importance of Fas for life and death of a T cell is, in some aspects, controversial. Fas has been suggested to play a role in selection/development of a T cell, the activation of a resting T cell and the homeostasis of a T cell population, an area that has attracted much attention. In this chapter I will focus on the discussion of the data available on the role of Fas in these fields. The role of FasL on activated T cells will be covered briefly.

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Authors and Affiliations

  1. Institute for Medical Microbiology, Technische Universität München, Münich, Germany

    Georg Häcker

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  1. Georg Häcker
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© 2006 Landes Bioscience and Springer Science+Business Media

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Häcker, G. (2006). Fas-Activation, Development and Homeostasis of T Cells. In: Fas Signaling. Medical Intelligence Unit. Springer, Boston, MA. https://doi.org/10.1007/0-387-34573-6_9

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