Fas-Activation, Development and Homeostasis of T Cells
- 248 Downloads
Fas (APO-1/CD95) is found on various cells of the immune system where its expression depends on differentiation and activation status of the cells. Analysis of the function of Fas on T lymphocytes has been the objective of many studies. Like in most cells carrying Fas, ligation by antibodies or FasL can induce apoptosis in T cells. Over the years, Fas has been implicated in the regulation of many aspects of T cell physiology. However, more recent data have challenged some of the earlier views, and the matter of the importance of Fas for life and death of a T cell is, in some aspects, controversial. Fas has been suggested to play a role in selection/development of a T cell, the activation of a resting T cell and the homeostasis of a T cell population, an area that has attracted much attention. In this chapter I will focus on the discussion of the data available on the role of Fas in these fields. The role of FasL on activated T cells will be covered briefly.
KeywordsImmune Privilege Activation Induce Cell Death Thymic Selection Autoimmune Uveitis Autoimmune Lymphoproliferative Syndrome
Unable to display preview. Download preview PDF.
- 47.Strasser A, Harris AH, Huang DCS et al. Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis. EMBO J 1996; 14:6136–6147.Google Scholar
- 49.Rescigno M, Piguet V, Valzasina B et al. Fas engagement induces the maturation of dendritic cells (DCs), the release of interleukin (IL)-l beta, and the production of interferon gamma in the absence of IL-12 during DC-T cell cognate interaction: A new role for Fas ligand in inflammatory responses. J Exp Med 2000; 192:1661–1668.PubMedCrossRefGoogle Scholar