Retrograde Fas Ligand Signaling

  • Andreas Linkermann
  • Jing Qian
  • Ottmar Janssen
Part of the Medical Intelligence Unit book series (MIUN)


As highlighted in the previous chapters, the interaction of Fas with Fas Ligand (FasL) affects many different aspects related to activation and apoptosis of Fas-expressing immune and tumor cells. Over the past five years we have learned, however, that FasL also acts as a costimulatory or accessory molecule for T cell activation. In the following chapter, we summarize what is known about FasL as a modulator of thymocyte development and selection or a regulator of mature T cell activation and effector function. Since to date almost no data are available on how a putative T cell receptor (TCR) /CD3-FasL crosstalk biochemically might work, we discuss ideas and hypotheses about the orchestration of retrograde signaling events also in the context of what is known from other members of the TNF family.


Casein Kinase Accessory Molecule Tumor Necrosis Factor Superfamily Tumor Necrosis Factor Family Member Tumor Necrosis Factor Superfamily Member 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Landes Bioscience and Springer Science+Business Media 2006

Authors and Affiliations

  • Andreas Linkermann
    • 1
  • Jing Qian
    • 1
  • Ottmar Janssen
    • 1
  1. 1.Institute of ImmunologyUniversity of KielKielGermany

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