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Fas-Induced Necrosis

  • Tom Vanden Berghe
  • Nele Festjens
  • Michael Kalai
  • Xavier Saelens
  • Peter Vandenabeele
Chapter
  • 268 Downloads
Part of the Medical Intelligence Unit book series (MIUN)

Abstract

Fas/CD95 is an important regulator of cell death in development and homeostasis of the immune system. Apoptosis is the most frequently observed type of cell death induced by Fas. It is characterized by cell shrinkage and nuclear fragmentation, while organelles and the plasma membrane retain their integrity for a prolonged period. Intensive studies of apoptotic cell death led to the discovery of the involvement of caspases. The first reports on necrotic caspase-independent cell death induced by Fas appeared in the late nineties. Necrotic cell death is characterized by minor nuclear changes and swelling of the cell, resulting in plasma and organelle membrane rupture. The current review focuses on Fas-initiated signaling events that allow a switch between apoptotic and necrotic cell death and on the mitochondrial processes that regulate an apoptotic or necrotic outcome. Finally, we describe events that are crucial for the execution of the necrotic cell death process.

Keywords

Jurkat Cell Mitochondrial Permeability Transition Death Domain Necrotic Cell Death Cell Death Differ 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Landes Bioscience and Springer Science+Business Media 2006

Authors and Affiliations

  • Tom Vanden Berghe
    • 1
  • Nele Festjens
    • 2
  • Michael Kalai
    • 2
  • Xavier Saelens
    • 2
  • Peter Vandenabeele
    • 1
  1. 1.Department of Molecular Biology Flanders Interuniversity Institute for BiotechnologyUniversity of GentGentBelgium
  2. 2.Molecular Signalling and Cell Death Unit Department of Molecular Biology Flanders Interuniversity Institute for BiotechnologyUniversity of GentGentBelgium

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