Regulation of Fas Signaling by FLIP Proteins

  • Margot Thome
Part of the Medical Intelligence Unit book series (MIUN)


Fas is a member of the tumor necrosis factor receptor family that can induce apoptosis by the recruitment and activation of caspase-8 (formerly called FLICE, MACH or MCH-5). Recently, caspase-8/FLICE inhibitory proteins (FLIPs) have been identified as proteins that counteract the caspase-8-dependent apoptosis-promoting activity of Fas and other death receptors. Viral and cellular FLIPs, which share structural similarity with caspase-8, are recruited to the death receptors upon ligand binding and inhibit caspase-8 activation. Viral FLIP family members are present in several lymphotropic herpesviruses and in a human poxvirus, and expression of viral FLIP proteins is thought to prevent or delay the elimination of virus-infected cells by cytotoxic T cells. Cellular FLIP has a similar anti-apoptotic function, but genetic studies have revealed additional, previously unanticipated roles in T-cell proliferation and heart development. Moreover, abnormal expression of cellular FLIP may play a role in autoimmune diseases, in tumor development and in cardiovascular disorders.


Death Domain Death Effector Domain Tumor Necrosis Factor Receptor Family Autoimmune Lymphoproliferative Syndrome Flip Expression 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Landes Bioscience and Springer Science+Business Media 2006

Authors and Affiliations

  • Margot Thome
    • 1
  1. 1.Institute of BiochemistryUniversity of Lausanne, BIL Biomedical Research CenterEpalingesSwitzerland

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