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Role of Ceramide in CD95 Signaling

  • Volker Teichgräber
  • Gabriele Hessler
  • Erich Gulbins
Chapter
  • 249 Downloads
Part of the Medical Intelligence Unit book series (MIUN)

Abstract

Recent studies indicate that the reorganization of receptor molecules in distinct domains of the cell membrane constitutes an important and general mechanism that is required for the initiation of signaling via various receptor molecules. Studies on the CD95 receptor might serve as a paradigm for the mechanism mediating receptor clustering/aggregation. These studies revealed activation of the acid sphingomyelinase and a release of ceramide in the outer leaflet of the cell membrane upon stimulation of CD95. The unique biophysical properties of ceramide trigger the formation of large ceramide-enriched membrane platforms that serve to trap and cluster the receptor. This process results in a high density of CD95 within a distinct area of the cell membrane and amplifies the primary signal generated by binding of the CD95 ligand and, thus, permits the induction of apoptosis. Furthermore, ceramide-enriched membrane domains mediate the assembling of the receptor with intracellular signaling molecules, in particular FADD, caspase 8, and the potassium channel Kvl.3 that finally mediate apoptosis initiated by CD95 ligation.

Keywords

Lipid Raft Receptor Molecule Membrane Raft CD95 Ligation Acid Sphingomyelinase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Landes Bioscience and Springer Science+Business Media 2006

Authors and Affiliations

  • Volker Teichgräber
    • 1
  • Gabriele Hessler
    • 1
  • Erich Gulbins
    • 1
  1. 1.Department of Molecular BiologyUniversity of Duisberg-EssenEssenGermany

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