FasL and Fas

Typical Members of the TNF Ligand and Receptor Family
  • Anja Krippner-Heidenreich
  • Peter Scheurich
Part of the Medical Intelligence Unit book series (MIUN)


The membrane receptor Fas is one of the central members of the TNF receptor superfamily, representing the prototype of an apoptosis inducer. Its cognate ligand, FasL, is expressed as a type II transmembrane protein, but also exists as a soluble molecule. As typical for all members of the TNF receptor superfamily, Fas signaling is induced by multimerization. Both molecules share structural features with their respective family members. Hallmarks of Fas are two and a half copies of a cysteine rich domain in the extracellular part, required for ligand binding and self-association and the intracellular death domain, essential for apoptosis induction. Characteristics of the FasL are the stable formation of homotrimers, each protomer consisting of two β-sheets in a typical “jelly roll” arrangement and a proline-rich domain involved in intracellular transport and reverse signaling.


Tumor Necrosis Factor Receptor Death Domain Tumor Necrosis Factor Receptor Superfamily Soluble FasL Human FasL 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Landes Bioscience and Springer Science+Business Media 2006

Authors and Affiliations

  • Anja Krippner-Heidenreich
    • 1
  • Peter Scheurich
    • 1
  1. 1.Institute of Cell Biology and ImmunologyUniversity of StuttgartStuttgartGermany

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