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FasL and Fas

Typical Members of the TNF Ligand and Receptor Family

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Fas Signaling

Part of the book series: Medical Intelligence Unit ((MIUN))

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Abstract

The membrane receptor Fas is one of the central members of the TNF receptor superfamily, representing the prototype of an apoptosis inducer. Its cognate ligand, FasL, is expressed as a type II transmembrane protein, but also exists as a soluble molecule. As typical for all members of the TNF receptor superfamily, Fas signaling is induced by multimerization. Both molecules share structural features with their respective family members. Hallmarks of Fas are two and a half copies of a cysteine rich domain in the extracellular part, required for ligand binding and self-association and the intracellular death domain, essential for apoptosis induction. Characteristics of the FasL are the stable formation of homotrimers, each protomer consisting of two β-sheets in a typical “jelly roll” arrangement and a proline-rich domain involved in intracellular transport and reverse signaling.

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  1. Institute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany

    Anja Krippner-Heidenreich & Peter Scheurich

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Krippner-Heidenreich, A., Scheurich, P. (2006). FasL and Fas. In: Fas Signaling. Medical Intelligence Unit. Springer, Boston, MA. https://doi.org/10.1007/0-387-34573-6_1

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