Summary
Dietary selenium deficiency in animals results in significant reduction of selenoprotein W (SEW) expression in their tissues. Selenium supplementation results in SeW accumulation predominantly in skeletal muscle and heart, suggesting a critical metabolic role for this protein in these tissues. SeW is expressed in the developing heart, muscle, brain, neural tube and otic ventricle during mouse development. SeW promoter studies indicated the presence of metal response element consensus sequences and binding sites for factors that suppress SeW expression. SeW exhibits glutathione-dependent redox properties in vivo. Aerobic growth conditions in microbes favor the production of SeW without the attached glutathione, whereas anaerobic growth conditions promote the glutathione-bound form. SeW levels are upregulated under oxidative stress in myoblasts. We suggest that SeW is a scavenger for reactive oxygen species such as hydrogen peroxide during muscle and nervous system development.
Keywords
- Neural Tube
- Luciferase Reporter Vector
- Keshan Disease
- Dietary Selenium Deficiency
- Anaerobic Growth Condition
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Kioussi, C., Whanger, P.D. (2006). Selenoprotein W in development and oxidative stress. In: Hatfield, D.L., Berry, M.J., Gladyshev, V.N. (eds) Selenium. Springer, Boston, MA. https://doi.org/10.1007/0-387-33827-6_12
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DOI: https://doi.org/10.1007/0-387-33827-6_12
Publisher Name: Springer, Boston, MA
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