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The Role of the Epithelial Barrier in Inflammatory Bowel Disease

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Immune Mechanisms in Inflammatory Bowel Disease

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 579))

Conclusion

The epithelial barrier protects the intestine from harmful antigens. The intestinal epithelial cell produces a wide array of molecules that play a role in initiating, maintaining, but also preventing and controlling mucosal inflammation. A defect in epithelial cell regulated barrier function may lead to continued exposure of intestinal immune cells to bacterially derived molecules leading to destructive intestinal inflammation that characterizes IBD.

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Author information

Authors and Affiliations

  1. Laboratory of Pediatrics, Department of Pediatric Gastroenterology, Erasmus MC, Rotterdam, The Netherlands

    Edward E. S. Nieuwenhuis

  2. Gastroenterology Division and Laboratory of Mucosal Immunology, Brigham and Women’s Hospital, Harvard, Massachusetts, USA

    Richard S. Blumberg

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  1. Edward E. S. Nieuwenhuis
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  2. Richard S. Blumberg
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Editors and Affiliations

  1. Gastroenterology Division and Laboratory of Mucosal Immunology, Brigham and Women’s Hospital, Harvard, Massachusetts, USA

    Richard S. Blumberg

  2. 1st Department of Medicine, Johannes-Gutenberg-University, Mainz, Germany

    Markus F. Neurath

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Nieuwenhuis, E.E.S., Blumberg, R.S. (2006). The Role of the Epithelial Barrier in Inflammatory Bowel Disease. In: Blumberg, R.S., Neurath, M.F. (eds) Immune Mechanisms in Inflammatory Bowel Disease. Advances in Experimental Medicine and Biology, vol 579. Springer, New York, NY. https://doi.org/10.1007/0-387-33778-4_7

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