Abstract
The Hedgehog signalling pathway is crucial for normal vertebrate growth and development. Recent studies would suggest that signalling capability is retained in the post-embryonic organism. Shh signalling has been identified in the adult immune system, participating in CD4+ T lymphocyte activation. Studies on fibrotic pulmonary disorders have demonstrated Shh in both human and mouse lung restricted to areas of active disease. Acute lung injury has also shown upregulated expression and together this data is highly suggestive for a functional role for Shh signalling in adult lung injury and disease. We propose that hedgehog signalling may contribute to epithelial injury and repair and act as an intermediary in cross-talk between damaged epithelium and the immune/inflammatory system.
Keywords
- Idiopathic Pulmonary Fibrosis
- Sonic Hedgehog
- Keratinocyte Growth Factor
- Idiopathic Pulmonary Fibrosis Patient
- Clara Cell
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Fitch, P.M., Wakelin, S.J., Lowrey, J.A., Wallace, W.A.H., Howie, S.E.M. (2006). Shh Expression in Pulmonary Injury and Disease. In: Hedgehog-Gli Signaling in Human Disease. Molecular Biology Intelligence Unit. Springer, Boston, MA. https://doi.org/10.1007/0-387-33777-6_9
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DOI: https://doi.org/10.1007/0-387-33777-6_9
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