Abstract
Epithelial organs such as the vertebrate hair undergo programmed self-renewal in part by controlling the growth of progenitor cells. The hedgehog signaling pathway regulates progenitor growth in a variety of tissues. This chapter discusses evidence for how the skin regulates the production of Shh ligand, the reception of the Shh signal, and maintenance of the signal to promote hair morphogenesis and prevent tumor formation.
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Oro, A.E. (2006). Spatial and Temporal Regulation of Hair Follicle Progenitors by Hedgehog Signaling. In: Hedgehog-Gli Signaling in Human Disease. Molecular Biology Intelligence Unit. Springer, Boston, MA. https://doi.org/10.1007/0-387-33777-6_4
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DOI: https://doi.org/10.1007/0-387-33777-6_4
Publisher Name: Springer, Boston, MA
Print ISBN: 978-0-387-25784-6
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