Abstract
The activities of the Hedgehog (Hh) protein family are central to the growth and patterning of developing tissues and organs in many different organisms. Hh proteins are secreted ligands synthesized in discrete regions. The receptor of Hh is Patched (Ptc) and it is expressed in the cells close to the source of Hh. Ptc binds the ligand and transduces a signal which is modulated depending on the context and the concentration of Hh received. Hh and several molecular components of the pathway were first identified and characterized in Drosophila, providing relevant milestones to our understanding on how the Hh signal is transduced. However, important gaps in the pathway still need to be elucidated. Some of these gaps converge on the Ptc receptor and its intriguing mechanisms of Hh reception and signal transduction. Mutations of Ptc that prevail both in animal and human populations are giving some clues on crucial aspects of its function. Patients bearing mutated forms of Ptc suffer a variety of serious diseases. Molecular and cellular studies in Drosophila have given us a clue of the function of Ptc receptor such as the normal topology and/or sorting of the receptor. Thus, a widened knowledge of the function of Ptc might help to design specific therapies for these disorders. This chapter focuses on recent advances that shed some light on how Ptc may operate in the cell.
Keywords
- Hedgehog Signaling
- Wing Imaginal Disc
- Nevoid Basal Cell Carcinoma Syndrome
- Morphogen Gradient
- Gorlin Syndrome
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Quijada, L., Callejo, A., Torroja, C., Guerrero, I. (2006). The Patched Receptor. In: Hedgehog-Gli Signaling in Human Disease. Molecular Biology Intelligence Unit. Springer, Boston, MA. https://doi.org/10.1007/0-387-33777-6_2
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DOI: https://doi.org/10.1007/0-387-33777-6_2
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